JP6883917B2 - 結晶性関節障害を処置するためのcxcr−2阻害剤 - Google Patents

結晶性関節障害を処置するためのcxcr−2阻害剤 Download PDF

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JP6883917B2
JP6883917B2 JP2018547929A JP2018547929A JP6883917B2 JP 6883917 B2 JP6883917 B2 JP 6883917B2 JP 2018547929 A JP2018547929 A JP 2018547929A JP 2018547929 A JP2018547929 A JP 2018547929A JP 6883917 B2 JP6883917 B2 JP 6883917B2
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compound
pharmaceutically acceptable
acceptable salt
sulfonamide
thio
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JP2019507791A (ja
JP2019507791A5 (https=
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ナナバティ,パヤル
マイナー,ジェフリー
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アルデア バイオサイエンシーズ インク.
アルデア バイオサイエンシーズ インク.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018547929A 2016-03-11 2017-03-09 結晶性関節障害を処置するためのcxcr−2阻害剤 Expired - Fee Related JP6883917B2 (ja)

Priority Applications (1)

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JP2021078242A JP7126014B2 (ja) 2016-03-11 2021-05-05 結晶性関節障害を処置するためのcxcr-2阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662307348P 2016-03-11 2016-03-11
US62/307,348 2016-03-11
PCT/US2017/021570 WO2017156270A1 (en) 2016-03-11 2017-03-09 Cxcr-2 inhibitors for treating crystal arthropathy disorders

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JP2021078242A Division JP7126014B2 (ja) 2016-03-11 2021-05-05 結晶性関節障害を処置するためのcxcr-2阻害剤

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JP2019507791A JP2019507791A (ja) 2019-03-22
JP2019507791A5 JP2019507791A5 (https=) 2020-04-30
JP6883917B2 true JP6883917B2 (ja) 2021-06-09

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JP2018547929A Expired - Fee Related JP6883917B2 (ja) 2016-03-11 2017-03-09 結晶性関節障害を処置するためのcxcr−2阻害剤
JP2021078242A Active JP7126014B2 (ja) 2016-03-11 2021-05-05 結晶性関節障害を処置するためのcxcr-2阻害剤

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US (1) US10772886B2 (https=)
EP (1) EP3426253A4 (https=)
JP (2) JP6883917B2 (https=)
CN (2) CN109152780B (https=)
AU (1) AU2017231832B2 (https=)
BR (1) BR112018068393A2 (https=)
CA (1) CA3017345A1 (https=)
CO (1) CO2018010880A2 (https=)
MX (1) MX386771B (https=)
WO (1) WO2017156270A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109152780B (zh) 2016-03-11 2021-10-01 阿迪亚生命科学公司 用于治疗结晶性关节病症的cxcr-2抑制剂
BR112020004697A2 (pt) * 2017-09-12 2020-10-27 Ardea Biosciences, Inc. inibidores de cxcr-2 para tratamento de distúrbios
EP3738956B1 (en) * 2018-01-11 2023-03-01 Shenzhen Optimum Biological Technology Co., Ltd Cxcr2 antagonist
CN114286819B (zh) 2019-07-11 2024-03-05 深圳嘉科生物科技有限公司 一种cxcr2拮抗剂的晶型及其应用
KR102260478B1 (ko) * 2019-08-19 2021-06-02 연세대학교 산학협력단 일나트륨 요소화물 결정 용해용 조성물
TW202210068A (zh) * 2020-06-05 2022-03-16 美商雅力思提雅治療公司 用於治療家族性地中海型發熱病的cxcr-2抑制劑
WO2022162021A1 (en) * 2021-01-27 2022-08-04 Astrazeneca Ab Verinurad compositions and methods of use

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AU2005210504B2 (en) 2004-01-30 2009-01-08 Merck Sharp & Dohme Corp. Crystalline polymorphs of a CXC-chemokine receptor ligand
KR101280095B1 (ko) 2004-08-28 2013-09-09 아스트라제네카 아베 케모킨 수용체 조절제로서의 피리미딘 술폰아미드 유도체
AU2008206231A1 (en) * 2007-01-19 2008-07-24 Takeda Pharmaceuticals U.S.A., Inc. Methods for preventing or reducing the number of gout flares using xanthine oxidoreductase inhibitors and anti-inflammatory agents
EP2203432A4 (en) 2007-09-21 2011-04-27 Glaxosmithkline Llc PROCESSING METHOD
US20090093548A1 (en) 2007-10-05 2009-04-09 Mutual Pharmaceutical Company, Inc Colchine compositions and methods
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CN102088993A (zh) 2008-03-20 2011-06-08 卡罗勒斯治疗公司 炎症的治疗方法
CA2730477A1 (en) 2008-07-16 2010-01-21 Astrazeneca Ab Pyrimidyl sulfonaminde derivative and its use for the treatment of chemokine mediated diseases
JP2012505160A (ja) 2008-10-06 2012-03-01 カロラス セラピューティクス, インク. 炎症を処置する方法
US8298533B2 (en) 2008-11-07 2012-10-30 Medimmune Limited Antibodies to IL-1R1
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WO2010071865A1 (en) * 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
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CA2811990C (en) * 2010-08-23 2023-03-21 Dean Y. Maeda Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators
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BR112020004697A2 (pt) 2017-09-12 2020-10-27 Ardea Biosciences, Inc. inibidores de cxcr-2 para tratamento de distúrbios

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Publication number Publication date
EP3426253A1 (en) 2019-01-16
JP2019507791A (ja) 2019-03-22
US20180235964A1 (en) 2018-08-23
WO2017156270A1 (en) 2017-09-14
EP3426253A4 (en) 2019-11-06
CN109152780B (zh) 2021-10-01
AU2017231832A1 (en) 2018-10-04
BR112018068393A2 (pt) 2019-01-15
CA3017345A1 (en) 2017-09-14
CN109152780A (zh) 2019-01-04
AU2017231832B2 (en) 2021-11-11
CO2018010880A2 (es) 2018-10-22
US10772886B2 (en) 2020-09-15
CN113893252A (zh) 2022-01-07
JP2021121600A (ja) 2021-08-26
MX386771B (es) 2025-03-19
JP7126014B2 (ja) 2022-08-25
MX2018010946A (es) 2019-05-23

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