JP6873053B2 - タンパク質脱アセチル化阻害剤の製造方法 - Google Patents

タンパク質脱アセチル化阻害剤の製造方法 Download PDF

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JP6873053B2
JP6873053B2 JP2017563541A JP2017563541A JP6873053B2 JP 6873053 B2 JP6873053 B2 JP 6873053B2 JP 2017563541 A JP2017563541 A JP 2017563541A JP 2017563541 A JP2017563541 A JP 2017563541A JP 6873053 B2 JP6873053 B2 JP 6873053B2
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JP2018518486A5 (enExample
JP2018518486A (ja
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ファルザネー・セイエディ
ジョン・エイチ・ヴァン・ドゥーザー
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Acetylon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2017563541A 2015-06-08 2016-06-08 タンパク質脱アセチル化阻害剤の製造方法 Active JP6873053B2 (ja)

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Application Number Priority Date Filing Date Title
US201562172624P 2015-06-08 2015-06-08
US62/172,624 2015-06-08
PCT/US2016/036434 WO2016200930A1 (en) 2015-06-08 2016-06-08 Methods of making protein deacetylase inhibitors

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JP2018518486A JP2018518486A (ja) 2018-07-12
JP2018518486A5 JP2018518486A5 (enExample) 2019-07-04
JP6873053B2 true JP6873053B2 (ja) 2021-05-19

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US (1) US10144714B2 (enExample)
EP (1) EP3303304B1 (enExample)
JP (1) JP6873053B2 (enExample)
CN (1) CN107922352B (enExample)
AR (1) AR105812A1 (enExample)
AU (2) AU2016276573A1 (enExample)
CA (1) CA2988594C (enExample)
ES (1) ES2769255T3 (enExample)
MX (1) MX369349B (enExample)
TW (1) TWI706937B (enExample)
WO (1) WO2016200930A1 (enExample)

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TWI706937B (zh) 2015-06-08 2020-10-11 美商艾斯特隆製藥公司 製備蛋白質去乙醯酶抑制劑之方法
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WO2018098168A1 (en) 2016-11-23 2018-05-31 Acetylon Pharmaceuticals, Inc. Pharmaceutical combinations comprising a histone deacetylase inhibitor and a programmed death-ligand 1 (pd-l1) inhibitor and methods of use thereof

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Publication number Publication date
EP3303304A1 (en) 2018-04-11
CA2988594A1 (en) 2016-12-15
WO2016200930A1 (en) 2016-12-15
US10144714B2 (en) 2018-12-04
JP2018518486A (ja) 2018-07-12
TWI706937B (zh) 2020-10-11
AU2020267299A1 (en) 2020-12-10
CN107922352A (zh) 2018-04-17
AU2016276573A1 (en) 2018-01-04
US20160355486A1 (en) 2016-12-08
AU2020267299B2 (en) 2022-07-07
MX2017015900A (es) 2018-11-09
CN107922352B (zh) 2021-08-06
AR105812A1 (es) 2017-11-15
MX369349B (es) 2019-11-06
TW201718517A (zh) 2017-06-01
ES2769255T3 (es) 2020-06-25
EP3303304B1 (en) 2019-11-20
WO2016200930A9 (en) 2017-02-23
CA2988594C (en) 2023-08-15

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