CA2988594C - Methods of making protein deacetylase inhibitors - Google Patents

Methods of making protein deacetylase inhibitors Download PDF

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Publication number
CA2988594C
CA2988594C CA2988594A CA2988594A CA2988594C CA 2988594 C CA2988594 C CA 2988594C CA 2988594 A CA2988594 A CA 2988594A CA 2988594 A CA2988594 A CA 2988594A CA 2988594 C CA2988594 C CA 2988594C
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Canada
Prior art keywords
compound
converting
acid
particular embodiment
reacting
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CA2988594A
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English (en)
French (fr)
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CA2988594A1 (en
Inventor
Farzaneh Seyedi
John H. Van Duzer
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Acetylon Pharmaceuticals Inc
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Acetylon Pharmaceuticals Inc
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Publication of CA2988594A1 publication Critical patent/CA2988594A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2988594A 2015-06-08 2016-06-08 Methods of making protein deacetylase inhibitors Active CA2988594C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562172624P 2015-06-08 2015-06-08
US62/172,624 2015-06-08
PCT/US2016/036434 WO2016200930A1 (en) 2015-06-08 2016-06-08 Methods of making protein deacetylase inhibitors

Publications (2)

Publication Number Publication Date
CA2988594A1 CA2988594A1 (en) 2016-12-15
CA2988594C true CA2988594C (en) 2023-08-15

Family

ID=56264043

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2988594A Active CA2988594C (en) 2015-06-08 2016-06-08 Methods of making protein deacetylase inhibitors

Country Status (11)

Country Link
US (1) US10144714B2 (enExample)
EP (1) EP3303304B1 (enExample)
JP (1) JP6873053B2 (enExample)
CN (1) CN107922352B (enExample)
AR (1) AR105812A1 (enExample)
AU (2) AU2016276573A1 (enExample)
CA (1) CA2988594C (enExample)
ES (1) ES2769255T3 (enExample)
MX (1) MX369349B (enExample)
TW (1) TWI706937B (enExample)
WO (1) WO2016200930A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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TWI706937B (zh) 2015-06-08 2020-10-11 美商艾斯特隆製藥公司 製備蛋白質去乙醯酶抑制劑之方法
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JP7100018B2 (ja) 2016-08-08 2022-07-12 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストンデアセチラーゼ６阻害剤及びｃｄ２０阻害抗体の薬学的組み合わせならびにその使用
EP3544600A4 (en) 2016-11-23 2020-06-17 Acetylon Pharmaceuticals, Inc. PHARMACEUTICAL COMBINATIONS WITH A HISTONE DEACETYLAS INHIBITOR AND A PROGRAMMED DEATH LIGAND-1 (PD-L1) INHIBITOR AND METHOD FOR USE THEREOF

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TWI706937B (zh) 2015-06-08 2020-10-11 美商艾斯特隆製藥公司 製備蛋白質去乙醯酶抑制劑之方法
JP7100018B2 (ja) 2016-08-08 2022-07-12 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストンデアセチラーゼ６阻害剤及びｃｄ２０阻害抗体の薬学的組み合わせならびにその使用

Also Published As

Publication number Publication date
MX369349B (es) 2019-11-06
TW201718517A (zh) 2017-06-01
AU2020267299A1 (en) 2020-12-10
CA2988594A1 (en) 2016-12-15
CN107922352A (zh) 2018-04-17
JP2018518486A (ja) 2018-07-12
EP3303304A1 (en) 2018-04-11
US20160355486A1 (en) 2016-12-08
EP3303304B1 (en) 2019-11-20
CN107922352B (zh) 2021-08-06
ES2769255T3 (es) 2020-06-25
WO2016200930A1 (en) 2016-12-15
AU2016276573A1 (en) 2018-01-04
TWI706937B (zh) 2020-10-11
JP6873053B2 (ja) 2021-05-19
AU2020267299B2 (en) 2022-07-07
AR105812A1 (es) 2017-11-15
MX2017015900A (es) 2018-11-09
WO2016200930A9 (en) 2017-02-23
US10144714B2 (en) 2018-12-04

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