AU2016276573A1 - Methods of making protein deacetylase inhibitors - Google Patents
Methods of making protein deacetylase inhibitors Download PDFInfo
- Publication number
- AU2016276573A1 AU2016276573A1 AU2016276573A AU2016276573A AU2016276573A1 AU 2016276573 A1 AU2016276573 A1 AU 2016276573A1 AU 2016276573 A AU2016276573 A AU 2016276573A AU 2016276573 A AU2016276573 A AU 2016276573A AU 2016276573 A1 AU2016276573 A1 AU 2016276573A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- pct
- converting
- composition
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- ZUKQDXJKYIIHBW-UHFFFAOYSA-N CCOC(c1cnc(N(c2ccccc2)c2ccccc2)nc1)=O Chemical compound CCOC(c1cnc(N(c2ccccc2)c2ccccc2)nc1)=O ZUKQDXJKYIIHBW-UHFFFAOYSA-N 0.000 description 2
- GFAWPYSWPKUABW-UHFFFAOYSA-N CCN(c1ccccc1)c(nc1)ncc1C(OCC)=C Chemical compound CCN(c1ccccc1)c(nc1)ncc1C(OCC)=C GFAWPYSWPKUABW-UHFFFAOYSA-N 0.000 description 1
- MMYPIVCZGPMEMY-UHFFFAOYSA-N OC(c1cnc(N(c2ccccc2)c2ccccc2)nc1)=O Chemical compound OC(c1cnc(N(c2ccccc2)c2ccccc2)nc1)=O MMYPIVCZGPMEMY-UHFFFAOYSA-N 0.000 description 1
- KVCUEYZPPXIXMV-UHFFFAOYSA-N OC(c1cnc(N(c2ccccc2)c2ccccc2Cl)nc1)=O Chemical compound OC(c1cnc(N(c2ccccc2)c2ccccc2Cl)nc1)=O KVCUEYZPPXIXMV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2020267299A AU2020267299B2 (en) | 2015-06-08 | 2020-11-13 | Methods of making protein deacetylase inhibitors |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562172624P | 2015-06-08 | 2015-06-08 | |
| US62/172,624 | 2015-06-08 | ||
| PCT/US2016/036434 WO2016200930A1 (en) | 2015-06-08 | 2016-06-08 | Methods of making protein deacetylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020267299A Division AU2020267299B2 (en) | 2015-06-08 | 2020-11-13 | Methods of making protein deacetylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2016276573A1 true AU2016276573A1 (en) | 2018-01-04 |
Family
ID=56264043
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016276573A Abandoned AU2016276573A1 (en) | 2015-06-08 | 2016-06-08 | Methods of making protein deacetylase inhibitors |
| AU2020267299A Active AU2020267299B2 (en) | 2015-06-08 | 2020-11-13 | Methods of making protein deacetylase inhibitors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020267299A Active AU2020267299B2 (en) | 2015-06-08 | 2020-11-13 | Methods of making protein deacetylase inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10144714B2 (enExample) |
| EP (1) | EP3303304B1 (enExample) |
| JP (1) | JP6873053B2 (enExample) |
| CN (1) | CN107922352B (enExample) |
| AR (1) | AR105812A1 (enExample) |
| AU (2) | AU2016276573A1 (enExample) |
| CA (1) | CA2988594C (enExample) |
| ES (1) | ES2769255T3 (enExample) |
| MX (1) | MX369349B (enExample) |
| TW (1) | TWI706937B (enExample) |
| WO (1) | WO2016200930A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS55227B1 (sr) * | 2010-01-22 | 2017-02-28 | Acetylon Pharmaceuticals Inc | Jedinjenja reverznog amida kao inhibitori protein deacetilaze i postupci za njihovu upotrebu |
| US9663825B2 (en) | 2012-04-19 | 2017-05-30 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
| US10144714B2 (en) | 2015-06-08 | 2018-12-04 | Acetylon Pharmaceuticals, Inc. | Methods of making protein deacetylase inhibitors |
| TW201718516A (zh) | 2015-06-08 | 2017-06-01 | 艾斯特隆製藥公司 | 組蛋白去乙醯酶抑制劑之晶形 |
| TW201803594A (zh) * | 2016-06-09 | 2018-02-01 | 達納-法伯癌症協會 | Hdac抑制劑與bet抑制劑之使用方法及醫藥組合 |
| US11324744B2 (en) | 2016-08-08 | 2022-05-10 | Acetylon Pharmaceuticals Inc. | Methods of use and pharmaceutical combinations of histone deacetylase inhibitors and CD20 inhibitory antibodies |
| US11497746B2 (en) | 2016-11-23 | 2022-11-15 | Acetylon Pharmaceuticals, Inc. | Pharmaceutical combinations comprising a histone deacetylase inhibitor and a programmed death-ligand 1 (PD-L1) inhibitor and methods of use thereof |
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|---|---|---|---|---|
| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| EP1280764B1 (en) | 2000-03-24 | 2010-11-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| JPWO2002074298A1 (ja) | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Ｉｌ−６産生阻害剤 |
| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| DE60222921T2 (de) | 2001-11-01 | 2008-08-07 | Janssen Pharmaceutica N.V. | Amidderivate als inhibitoren der glycogensynthasekinase-3-beta |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2006520796A (ja) | 2003-03-17 | 2006-09-14 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼインヒビター |
| EP1644323B1 (en) | 2003-07-07 | 2015-03-18 | Georgetown University | Histone deacetylase inhibitors and methods of use thereof |
| CA2561617A1 (en) | 2004-04-05 | 2005-10-20 | Aton Pharma, Inc. | Histone deacetylase inhibitor prodrugs |
| US8999289B2 (en) | 2005-03-22 | 2015-04-07 | President And Fellows Of Harvard College | Treatment of protein degradation disorders |
| JP2009509923A (ja) | 2005-08-26 | 2009-03-12 | メシルジーン、インコーポレイテッド | ヒストンデアセチラーゼのベンゾジアゼピン及びベンゾピペラジン類似体阻害薬 |
| US8222423B2 (en) | 2006-02-14 | 2012-07-17 | Dana-Farber Cancer Institute, Inc. | Bifunctional histone deacetylase inhibitors |
| CA2654540C (en) | 2006-05-03 | 2017-01-17 | President And Fellows Of Harvard College | Histone deacetylase and tubulin deacetylase inhibitors |
| WO2007144341A1 (en) | 2006-06-12 | 2007-12-21 | Vrije Universiteit Brussel | Differentiation of rat liver epithelial cells into hepatocyte-like cells |
| ES2288802B1 (es) | 2006-07-07 | 2008-12-16 | Universidad De Granada | Nuevos derivados de ftalimida como inhibidores de las histonas desacetilasas. |
| CN101534831B (zh) | 2006-09-11 | 2013-07-17 | 柯瑞斯公司 | 包含锌结合基团的取代的酪氨酸抑制剂 |
| CN101951930A (zh) | 2008-02-19 | 2011-01-19 | 阿奈斯特药品株式会社 | 对身体功能的恢复有用的口服或经肠组合物 |
| CA2731730C (en) | 2008-07-23 | 2017-06-13 | President And Fellows Of Harvard College | Deacetylase inhibitors and uses thereof |
| EP2429987A4 (en) | 2009-05-15 | 2012-10-03 | Korea Res Inst Chem Tech | AMIDE COMPOUND, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
| US8716344B2 (en) | 2009-08-11 | 2014-05-06 | President And Fellows Of Harvard College | Class- and isoform-specific HDAC inhibitors and uses thereof |
| MA33926B1 (fr) * | 2009-12-17 | 2013-01-02 | Merck Sharp & Dohme | Aminopyrimidines en tant qu'inhibiteurs de la syk |
| EP2638009A4 (en) | 2010-01-08 | 2014-06-11 | Harvard College | FLUORINATED HDAC HEMMER AND USES THEREOF |
| RS55227B1 (sr) | 2010-01-22 | 2017-02-28 | Acetylon Pharmaceuticals Inc | Jedinjenja reverznog amida kao inhibitori protein deacetilaze i postupci za njihovu upotrebu |
| WO2011146855A1 (en) | 2010-05-21 | 2011-11-24 | The Trustees Of Columbia University In The City Of New York | Selective hdac inhibitors |
| WO2012018499A2 (en) | 2010-08-05 | 2012-02-09 | Acetylon Pharmaceuticals | Specific regulation of cytokine levels by hdac6 inhibitors |
| CN107011270A (zh) | 2010-11-16 | 2017-08-04 | 阿塞蒂隆制药公司 | 作为蛋白质去乙酰化酶抑制剂的嘧啶羟基酰胺化合物和其使用方法 |
| JP6169076B2 (ja) | 2011-07-20 | 2017-07-26 | ザ ジェネラル ホスピタル コーポレイション | 骨疾患の処置のためのヒストン脱アセチル化酵素６選択的阻害剤 |
| US8841301B2 (en) | 2011-09-26 | 2014-09-23 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
| JP5724851B2 (ja) * | 2011-11-30 | 2015-05-27 | 東レ株式会社 | Ｎ−（ヨードフェニル）ピリミジニルアミン誘導体の製造方法 |
| US9663825B2 (en) | 2012-04-19 | 2017-05-30 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
| WO2014059306A1 (en) | 2012-10-12 | 2014-04-17 | The Trustees Of The University Of Pennsylvania | Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof |
| US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| JP2016511237A (ja) | 2013-02-01 | 2016-04-14 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 選択的ｈｄａｃ３阻害剤 |
| US9139583B2 (en) | 2013-02-01 | 2015-09-22 | Acetylon Pharmaceuticals, Inc. | Selective HDAC3 inhibitors |
| US20140357512A1 (en) | 2013-06-03 | 2014-12-04 | Acetylon Pharmaceuticals, Inc. | Histone deacetylase (hdac) biomarkers in multiple myeloma |
| EP3046559A4 (en) | 2013-09-20 | 2017-03-22 | Acetylon Pharmaceuticals, Inc. | Treatment of diseases caused by abnormal lymphocyte function with an hdac6 inhibitor |
| WO2015054099A1 (en) | 2013-10-08 | 2015-04-16 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase inhibitors and either her2 inhibitors or pi3k inhibitors |
| US9278963B2 (en) | 2013-10-10 | 2016-03-08 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors |
| US20150105383A1 (en) | 2013-10-10 | 2015-04-16 | Acetylon Pharmaceuticals, Inc. | HDAC Inhibitors, Alone Or In Combination With PI3K Inhibitors, For Treating Non-Hodgkin's Lymphoma |
| JP2016536354A (ja) | 2013-10-10 | 2016-11-24 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 非ホジキンリンパ腫を治療するための、ｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との組み合わせ |
| PE20161342A1 (es) | 2013-10-11 | 2016-12-31 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona desacetilasa y farmacos inmunomoduladores |
| ES2918673T3 (es) | 2013-10-24 | 2022-07-19 | Mayo Found Medical Education & Res | Tratamiento de enfermedades poliquísticas con un inhibidor de HDAC6 |
| PE20161030A1 (es) | 2013-12-03 | 2016-11-06 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores |
| US20150176076A1 (en) | 2013-12-20 | 2015-06-25 | Acetylon Pharmaceuticals, Inc. | Histone deacetylase 6 (hdac6) biomarkers in multiple myeloma |
| US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| US20150359794A1 (en) | 2014-06-13 | 2015-12-17 | Buck Institute For Research On Aging | Impairment of the large ribosomal subunit protein rpl24 by depletion or acetylation |
| AU2015288060A1 (en) | 2014-07-07 | 2017-02-09 | Acetylon Pharmaceuticals, Inc. | Treatment of leukemia with histone deacetylase inhibitors |
| CA2963681A1 (en) | 2014-10-08 | 2016-04-14 | Acetylon Pharmaceuticals, Inc. | Induction of gata2 by hdac1 and hdac2 inhibitors |
| WO2016090230A1 (en) | 2014-12-05 | 2016-06-09 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds for treating peripheral neuropathy |
| CA2969790A1 (en) | 2014-12-05 | 2016-06-09 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
| HK1251566A1 (zh) | 2014-12-12 | 2019-02-01 | Regenacy Pharmaceuticals, Llc | 作为hdac1/2抑制剂的呱啶衍生物 |
| US20160339022A1 (en) | 2015-04-17 | 2016-11-24 | Acetylon Pharmaceuticals Inc. | Treatment of neuroblastoma with histone deacetylase inhibitors |
| US10272084B2 (en) | 2015-06-01 | 2019-04-30 | Regenacy Pharmaceuticals, Llc | Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy |
| US10144714B2 (en) | 2015-06-08 | 2018-12-04 | Acetylon Pharmaceuticals, Inc. | Methods of making protein deacetylase inhibitors |
| TW201718516A (zh) | 2015-06-08 | 2017-06-01 | 艾斯特隆製藥公司 | 組蛋白去乙醯酶抑制劑之晶形 |
| US11324744B2 (en) | 2016-08-08 | 2022-05-10 | Acetylon Pharmaceuticals Inc. | Methods of use and pharmaceutical combinations of histone deacetylase inhibitors and CD20 inhibitory antibodies |
-
2016
- 2016-06-08 US US15/176,826 patent/US10144714B2/en active Active
- 2016-06-08 CA CA2988594A patent/CA2988594C/en active Active
- 2016-06-08 AU AU2016276573A patent/AU2016276573A1/en not_active Abandoned
- 2016-06-08 AR ARP160101701A patent/AR105812A1/es unknown
- 2016-06-08 CN CN201680046553.8A patent/CN107922352B/zh active Active
- 2016-06-08 TW TW105118213A patent/TWI706937B/zh active
- 2016-06-08 WO PCT/US2016/036434 patent/WO2016200930A1/en not_active Ceased
- 2016-06-08 JP JP2017563541A patent/JP6873053B2/ja active Active
- 2016-06-08 EP EP16732810.3A patent/EP3303304B1/en active Active
- 2016-06-08 ES ES16732810T patent/ES2769255T3/es active Active
- 2016-06-08 MX MX2017015900A patent/MX369349B/es active IP Right Grant
-
2020
- 2020-11-13 AU AU2020267299A patent/AU2020267299B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AR105812A1 (es) | 2017-11-15 |
| MX369349B (es) | 2019-11-06 |
| MX2017015900A (es) | 2018-11-09 |
| US10144714B2 (en) | 2018-12-04 |
| CA2988594C (en) | 2023-08-15 |
| AU2020267299B2 (en) | 2022-07-07 |
| WO2016200930A1 (en) | 2016-12-15 |
| JP2018518486A (ja) | 2018-07-12 |
| CA2988594A1 (en) | 2016-12-15 |
| WO2016200930A9 (en) | 2017-02-23 |
| TWI706937B (zh) | 2020-10-11 |
| CN107922352B (zh) | 2021-08-06 |
| CN107922352A (zh) | 2018-04-17 |
| TW201718517A (zh) | 2017-06-01 |
| AU2020267299A1 (en) | 2020-12-10 |
| EP3303304B1 (en) | 2019-11-20 |
| ES2769255T3 (es) | 2020-06-25 |
| JP6873053B2 (ja) | 2021-05-19 |
| US20160355486A1 (en) | 2016-12-08 |
| EP3303304A1 (en) | 2018-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |