AU2016276573A1 - Methods of making protein deacetylase inhibitors - Google Patents
Methods of making protein deacetylase inhibitors Download PDFInfo
- Publication number
- AU2016276573A1 AU2016276573A1 AU2016276573A AU2016276573A AU2016276573A1 AU 2016276573 A1 AU2016276573 A1 AU 2016276573A1 AU 2016276573 A AU2016276573 A AU 2016276573A AU 2016276573 A AU2016276573 A AU 2016276573A AU 2016276573 A1 AU2016276573 A1 AU 2016276573A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- pct
- converting
- composition
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- ZUKQDXJKYIIHBW-UHFFFAOYSA-N CCOC(c1cnc(N(c2ccccc2)c2ccccc2)nc1)=O Chemical compound CCOC(c1cnc(N(c2ccccc2)c2ccccc2)nc1)=O ZUKQDXJKYIIHBW-UHFFFAOYSA-N 0.000 description 2
- GFAWPYSWPKUABW-UHFFFAOYSA-N CCN(c1ccccc1)c(nc1)ncc1C(OCC)=C Chemical compound CCN(c1ccccc1)c(nc1)ncc1C(OCC)=C GFAWPYSWPKUABW-UHFFFAOYSA-N 0.000 description 1
- MMYPIVCZGPMEMY-UHFFFAOYSA-N OC(c1cnc(N(c2ccccc2)c2ccccc2)nc1)=O Chemical compound OC(c1cnc(N(c2ccccc2)c2ccccc2)nc1)=O MMYPIVCZGPMEMY-UHFFFAOYSA-N 0.000 description 1
- KVCUEYZPPXIXMV-UHFFFAOYSA-N OC(c1cnc(N(c2ccccc2)c2ccccc2Cl)nc1)=O Chemical compound OC(c1cnc(N(c2ccccc2)c2ccccc2Cl)nc1)=O KVCUEYZPPXIXMV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2020267299A AU2020267299B2 (en) | 2015-06-08 | 2020-11-13 | Methods of making protein deacetylase inhibitors |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562172624P | 2015-06-08 | 2015-06-08 | |
| US62/172,624 | 2015-06-08 | ||
| PCT/US2016/036434 WO2016200930A1 (en) | 2015-06-08 | 2016-06-08 | Methods of making protein deacetylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020267299A Division AU2020267299B2 (en) | 2015-06-08 | 2020-11-13 | Methods of making protein deacetylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2016276573A1 true AU2016276573A1 (en) | 2018-01-04 |
Family
ID=56264043
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016276573A Abandoned AU2016276573A1 (en) | 2015-06-08 | 2016-06-08 | Methods of making protein deacetylase inhibitors |
| AU2020267299A Active AU2020267299B2 (en) | 2015-06-08 | 2020-11-13 | Methods of making protein deacetylase inhibitors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020267299A Active AU2020267299B2 (en) | 2015-06-08 | 2020-11-13 | Methods of making protein deacetylase inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10144714B2 (enExample) |
| EP (1) | EP3303304B1 (enExample) |
| JP (1) | JP6873053B2 (enExample) |
| CN (1) | CN107922352B (enExample) |
| AR (1) | AR105812A1 (enExample) |
| AU (2) | AU2016276573A1 (enExample) |
| CA (1) | CA2988594C (enExample) |
| ES (1) | ES2769255T3 (enExample) |
| MX (1) | MX369349B (enExample) |
| TW (1) | TWI706937B (enExample) |
| WO (1) | WO2016200930A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102933558B (zh) * | 2010-01-22 | 2016-03-16 | 埃斯泰隆制药公司 | 作为蛋白质去乙酰化酶抑制剂的反向酰胺化合物及其使用方法 |
| HK1207403A1 (en) | 2012-04-19 | 2016-01-29 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
| AR104935A1 (es) | 2015-06-08 | 2017-08-23 | Acetylon Pharmaceuticals Inc | Formas cristalinas de un inhibidor de histona deacetilasa |
| ES2769255T3 (es) | 2015-06-08 | 2020-06-25 | Acetylon Pharmaceuticals Inc | Métodos para fabricar inhibidores de la proteína desacetilasa |
| TW201803594A (zh) * | 2016-06-09 | 2018-02-01 | 達納-法伯癌症協會 | Hdac抑制劑與bet抑制劑之使用方法及醫藥組合 |
| US11324744B2 (en) | 2016-08-08 | 2022-05-10 | Acetylon Pharmaceuticals Inc. | Methods of use and pharmaceutical combinations of histone deacetylase inhibitors and CD20 inhibitory antibodies |
| EP3544600A4 (en) | 2016-11-23 | 2020-06-17 | Acetylon Pharmaceuticals, Inc. | Pharmaceutical combinations comprising a histone deacetylase inhibitor and a programmed death-ligand 1 (pd-l1) inhibitor and methods of use thereof |
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|---|---|---|---|---|
| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| US7288567B2 (en) | 2000-03-24 | 2007-10-30 | Methylgene Inc. | Inhibitors of histone deacetylase |
| WO2002074298A1 (en) | 2001-03-21 | 2002-09-26 | Ono Pharmaceutical Co., Ltd. | Il-6 production inhibitors |
| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| HUP0402330A3 (en) | 2001-11-01 | 2010-03-29 | Janssen Pharmaceutica Nv | Amide derivatives as glycogen synthase kinase 3-beta inhibitors, process for producing them, pharmaceutical compositions containing them and use thereof |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1608628A2 (en) | 2003-03-17 | 2005-12-28 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| WO2005007091A2 (en) | 2003-07-07 | 2005-01-27 | Georgetown University | Histone deacetylase inhibitors and methods of use thereof |
| WO2005097747A1 (en) | 2004-04-05 | 2005-10-20 | Aton Pharma, Inc. | Histone deacetylase inhibitor prodrugs |
| US8999289B2 (en) | 2005-03-22 | 2015-04-07 | President And Fellows Of Harvard College | Treatment of protein degradation disorders |
| AU2006284403A1 (en) | 2005-08-26 | 2007-03-01 | Methylgene Inc. | Benzodiazepine and benzopiperazine analog inhibitors of histone deacetylase |
| US8222423B2 (en) | 2006-02-14 | 2012-07-17 | Dana-Farber Cancer Institute, Inc. | Bifunctional histone deacetylase inhibitors |
| AU2007248656B2 (en) | 2006-05-03 | 2013-04-04 | Dana-Farber Cancer Institute, Inc. | Histone deacetylase and tubulin deacetylase inhibitors |
| US20100278782A1 (en) | 2006-06-12 | 2010-11-04 | Vrije Universiteit Brussel | Differentiation of rat liver epithelial cells into hepatocyte-like cells |
| ES2288802B1 (es) | 2006-07-07 | 2008-12-16 | Universidad De Granada | Nuevos derivados de ftalimida como inhibidores de las histonas desacetilasas. |
| WO2008033746A2 (en) | 2006-09-11 | 2008-03-20 | Curis, Inc. | Tyrosine kinase inhibitors containing a zinc binding moiety |
| US8778410B2 (en) | 2008-02-19 | 2014-07-15 | Earnest Medicine Co., Ltd. | Oral or enteral composition useful for recovery of physical functions |
| KR101708946B1 (ko) | 2008-07-23 | 2017-02-21 | 다나-파버 캔서 인스티튜트 인크. | 탈아세틸화제 억제제 및 그것의 용도 |
| EP2429987A4 (en) | 2009-05-15 | 2012-10-03 | Korea Res Inst Chem Tech | AMIDE COMPOUND, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
| WO2011019393A2 (en) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
| US8759366B2 (en) * | 2009-12-17 | 2014-06-24 | Merck Sharp & Dohme Corp. | Aminopyrimidines as SYK inhibitors |
| US20130040998A1 (en) | 2010-01-08 | 2013-02-14 | Dana-Farber Cancer Institute, Inc. | Fluorinated hdac inhibitors and uses thereof |
| CN102933558B (zh) | 2010-01-22 | 2016-03-16 | 埃斯泰隆制药公司 | 作为蛋白质去乙酰化酶抑制剂的反向酰胺化合物及其使用方法 |
| CA2800143A1 (en) | 2010-05-21 | 2011-11-24 | The Trustees Of Columbia University In The City Of New York | Selective hdac inhibitors |
| WO2012018499A2 (en) | 2010-08-05 | 2012-02-09 | Acetylon Pharmaceuticals | Specific regulation of cytokine levels by hdac6 inhibitors |
| EP3067346A1 (en) | 2010-11-16 | 2016-09-14 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof |
| WO2013013113A2 (en) | 2011-07-20 | 2013-01-24 | The General Hospital Corporation | Histone deacetylase 6 selective inhibitors for the treatment of bone disease |
| US8841301B2 (en) | 2011-09-26 | 2014-09-23 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
| JP5724851B2 (ja) * | 2011-11-30 | 2015-05-27 | 東レ株式会社 | Ｎ−（ヨードフェニル）ピリミジニルアミン誘導体の製造方法 |
| HK1207403A1 (en) | 2012-04-19 | 2016-01-29 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
| JP2015533173A (ja) | 2012-10-12 | 2015-11-19 | トラスティース・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | タンパク質脱アセチル化酵素阻害剤としてのピリミジンヒドロキシアミド化合物およびその使用方法 |
| US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| US9139583B2 (en) | 2013-02-01 | 2015-09-22 | Acetylon Pharmaceuticals, Inc. | Selective HDAC3 inhibitors |
| US9096549B2 (en) | 2013-02-01 | 2015-08-04 | Acetylon Pharmaceuticals, Inc. | Selective HDAC3 inhibitors |
| JP2016523236A (ja) | 2013-06-03 | 2016-08-08 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 多発性骨髄腫におけるヒストン脱アセチル化酵素（ｈｄａｃ）バイオマーカー |
| WO2015042418A1 (en) | 2013-09-20 | 2015-03-26 | Acetylon Pharmaceuticals, Inc. | Treatment of diseases caused by abnormal lymphocyte function with an hdac6 inhibitor |
| ES2929576T3 (es) | 2013-10-08 | 2022-11-30 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona deacetilasa 6 y el inhibidor de Her2 lapatinib para el uso en el tratamiento del cáncer de mama |
| ES2862126T3 (es) | 2013-10-10 | 2021-10-07 | Acetylon Pharmaceuticals Inc | Compuestos de pirimidín-hidroxiamida como inhibidores de histona desacetilasa |
| JP2016536354A (ja) | 2013-10-10 | 2016-11-24 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 非ホジキンリンパ腫を治療するための、ｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との組み合わせ |
| ES2818933T3 (es) | 2013-10-10 | 2021-04-14 | Acetylon Pharmaceuticals Inc | Inhibidores de la HDAC en combinación con los inhibidores de la pi3k, para el tratamiento del linfoma no Hodgkin |
| WO2015054175A1 (en) | 2013-10-11 | 2015-04-16 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deactylase inhibitors and immunomodulatory drugs |
| EP3060217B1 (en) | 2013-10-24 | 2022-06-08 | Mayo Foundation for Medical Education and Research | Treatment of polycystic diseases with an hdac6 inhibitor |
| MX2016007251A (es) | 2013-12-03 | 2016-09-07 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores. |
| ES2936812T3 (es) | 2013-12-20 | 2023-03-22 | Acetylon Pharmaceuticals Inc | Biomarcadores de histona desacetilasa 6 (HDAC6) en mieloma múltiple |
| US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| US20150359794A1 (en) | 2014-06-13 | 2015-12-17 | Buck Institute For Research On Aging | Impairment of the large ribosomal subunit protein rpl24 by depletion or acetylation |
| EA201790142A1 (ru) | 2014-07-07 | 2017-07-31 | Эситайлон Фармасьютикалз, Инк. | Лечение лейкоза ингибиторами гистондеацетилазы |
| US20160137630A1 (en) | 2014-10-08 | 2016-05-19 | Acetylon Pharmaceuticals, Inc. | Induction of gata2 by hdac1 and hdac2 inhibitors |
| AU2015356779A1 (en) | 2014-12-05 | 2017-07-13 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine for use in the treatment of lymphoma |
| WO2016090230A1 (en) | 2014-12-05 | 2016-06-09 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds for treating peripheral neuropathy |
| EP3292113B1 (en) | 2014-12-12 | 2020-07-08 | Regenacy Pharmaceuticals, LLC | Piperidine derivatives as hdac1/2 inhibitors |
| US20160339022A1 (en) | 2015-04-17 | 2016-11-24 | Acetylon Pharmaceuticals Inc. | Treatment of neuroblastoma with histone deacetylase inhibitors |
| US10272084B2 (en) | 2015-06-01 | 2019-04-30 | Regenacy Pharmaceuticals, Llc | Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy |
| ES2769255T3 (es) | 2015-06-08 | 2020-06-25 | Acetylon Pharmaceuticals Inc | Métodos para fabricar inhibidores de la proteína desacetilasa |
| AR104935A1 (es) | 2015-06-08 | 2017-08-23 | Acetylon Pharmaceuticals Inc | Formas cristalinas de un inhibidor de histona deacetilasa |
| US11324744B2 (en) | 2016-08-08 | 2022-05-10 | Acetylon Pharmaceuticals Inc. | Methods of use and pharmaceutical combinations of histone deacetylase inhibitors and CD20 inhibitory antibodies |
-
2016
- 2016-06-08 ES ES16732810T patent/ES2769255T3/es active Active
- 2016-06-08 CN CN201680046553.8A patent/CN107922352B/zh active Active
- 2016-06-08 US US15/176,826 patent/US10144714B2/en active Active
- 2016-06-08 WO PCT/US2016/036434 patent/WO2016200930A1/en not_active Ceased
- 2016-06-08 CA CA2988594A patent/CA2988594C/en active Active
- 2016-06-08 JP JP2017563541A patent/JP6873053B2/ja active Active
- 2016-06-08 TW TW105118213A patent/TWI706937B/zh active
- 2016-06-08 EP EP16732810.3A patent/EP3303304B1/en active Active
- 2016-06-08 MX MX2017015900A patent/MX369349B/es active IP Right Grant
- 2016-06-08 AR ARP160101701A patent/AR105812A1/es unknown
- 2016-06-08 AU AU2016276573A patent/AU2016276573A1/en not_active Abandoned
-
2020
- 2020-11-13 AU AU2020267299A patent/AU2020267299B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020267299B2 (en) | 2022-07-07 |
| US10144714B2 (en) | 2018-12-04 |
| AU2020267299A1 (en) | 2020-12-10 |
| US20160355486A1 (en) | 2016-12-08 |
| WO2016200930A9 (en) | 2017-02-23 |
| TW201718517A (zh) | 2017-06-01 |
| EP3303304A1 (en) | 2018-04-11 |
| ES2769255T3 (es) | 2020-06-25 |
| MX2017015900A (es) | 2018-11-09 |
| MX369349B (es) | 2019-11-06 |
| WO2016200930A1 (en) | 2016-12-15 |
| TWI706937B (zh) | 2020-10-11 |
| CA2988594A1 (en) | 2016-12-15 |
| CN107922352B (zh) | 2021-08-06 |
| AR105812A1 (es) | 2017-11-15 |
| EP3303304B1 (en) | 2019-11-20 |
| JP2018518486A (ja) | 2018-07-12 |
| CA2988594C (en) | 2023-08-15 |
| CN107922352A (zh) | 2018-04-17 |
| JP6873053B2 (ja) | 2021-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |