AU2016276573A1 - Methods of making protein deacetylase inhibitors - Google Patents

Methods of making protein deacetylase inhibitors Download PDF

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Publication number
AU2016276573A1
AU2016276573A1 AU2016276573A AU2016276573A AU2016276573A1 AU 2016276573 A1 AU2016276573 A1 AU 2016276573A1 AU 2016276573 A AU2016276573 A AU 2016276573A AU 2016276573 A AU2016276573 A AU 2016276573A AU 2016276573 A1 AU2016276573 A1 AU 2016276573A1
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AU
Australia
Prior art keywords
compound
pct
converting
composition
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2016276573A
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English (en)
Inventor
Farzaneh Seyedi
John H. Van Duzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acetylon Pharmaceuticals Inc
Original Assignee
Acetylon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acetylon Pharmaceuticals Inc filed Critical Acetylon Pharmaceuticals Inc
Publication of AU2016276573A1 publication Critical patent/AU2016276573A1/en
Priority to AU2020267299A priority Critical patent/AU2020267299B2/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2016276573A 2015-06-08 2016-06-08 Methods of making protein deacetylase inhibitors Abandoned AU2016276573A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020267299A AU2020267299B2 (en) 2015-06-08 2020-11-13 Methods of making protein deacetylase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562172624P 2015-06-08 2015-06-08
US62/172,624 2015-06-08
PCT/US2016/036434 WO2016200930A1 (en) 2015-06-08 2016-06-08 Methods of making protein deacetylase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020267299A Division AU2020267299B2 (en) 2015-06-08 2020-11-13 Methods of making protein deacetylase inhibitors

Publications (1)

Publication Number Publication Date
AU2016276573A1 true AU2016276573A1 (en) 2018-01-04

Family

ID=56264043

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016276573A Abandoned AU2016276573A1 (en) 2015-06-08 2016-06-08 Methods of making protein deacetylase inhibitors
AU2020267299A Active AU2020267299B2 (en) 2015-06-08 2020-11-13 Methods of making protein deacetylase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020267299A Active AU2020267299B2 (en) 2015-06-08 2020-11-13 Methods of making protein deacetylase inhibitors

Country Status (11)

Country Link
US (1) US10144714B2 (enExample)
EP (1) EP3303304B1 (enExample)
JP (1) JP6873053B2 (enExample)
CN (1) CN107922352B (enExample)
AR (1) AR105812A1 (enExample)
AU (2) AU2016276573A1 (enExample)
CA (1) CA2988594C (enExample)
ES (1) ES2769255T3 (enExample)
MX (1) MX369349B (enExample)
TW (1) TWI706937B (enExample)
WO (1) WO2016200930A1 (enExample)

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* Cited by examiner, † Cited by third party
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JP2015515279A (ja) 2012-04-19 2015-05-28 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 治療に反応する患者を同定するバイオマーカーおよびそのような患者の治療
JP6816036B2 (ja) 2015-06-08 2021-01-20 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ヒストン脱アセチル化阻害剤の結晶形態
WO2016200930A1 (en) 2015-06-08 2016-12-15 Acetylon Pharmaceuticals, Inc. Methods of making protein deacetylase inhibitors
TW201803594A (zh) * 2016-06-09 2018-02-01 達納-法伯癌症協會 Hdac抑制劑與bet抑制劑之使用方法及醫藥組合
JP7100018B2 (ja) 2016-08-08 2022-07-12 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストンデアセチラーゼ６阻害剤及びｃｄ２０阻害抗体の薬学的組み合わせならびにその使用
JP7090611B2 (ja) 2016-11-23 2022-06-24 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストン脱アセチル化酵素阻害剤とプログラム細胞死リガンド１（ｐｄ－ｌ１）阻害剤とを含む医薬組み合わせ物及びその使用方法

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MA33926B1 (fr) * 2009-12-17 2013-01-02 Merck Sharp & Dohme Aminopyrimidines en tant qu'inhibiteurs de la syk
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WO2012018499A2 (en) 2010-08-05 2012-02-09 Acetylon Pharmaceuticals Specific regulation of cytokine levels by hdac6 inhibitors
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JP7100018B2 (ja) 2016-08-08 2022-07-12 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストンデアセチラーゼ６阻害剤及びｃｄ２０阻害抗体の薬学的組み合わせならびにその使用

Also Published As

Publication number Publication date
US10144714B2 (en) 2018-12-04
AU2020267299A1 (en) 2020-12-10
CN107922352B (zh) 2021-08-06
JP6873053B2 (ja) 2021-05-19
AR105812A1 (es) 2017-11-15
WO2016200930A9 (en) 2017-02-23
ES2769255T3 (es) 2020-06-25
JP2018518486A (ja) 2018-07-12
WO2016200930A1 (en) 2016-12-15
TWI706937B (zh) 2020-10-11
TW201718517A (zh) 2017-06-01
US20160355486A1 (en) 2016-12-08
CA2988594A1 (en) 2016-12-15
CN107922352A (zh) 2018-04-17
EP3303304B1 (en) 2019-11-20
EP3303304A1 (en) 2018-04-11
AU2020267299B2 (en) 2022-07-07
MX2017015900A (es) 2018-11-09
MX369349B (es) 2019-11-06
CA2988594C (en) 2023-08-15

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