JP6859323B2 - カルボキシ置換(ヘテロ)芳香環誘導体並びにその調製方法及び使用 - Google Patents
カルボキシ置換(ヘテロ)芳香環誘導体並びにその調製方法及び使用 Download PDFInfo
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- JP6859323B2 JP6859323B2 JP2018510463A JP2018510463A JP6859323B2 JP 6859323 B2 JP6859323 B2 JP 6859323B2 JP 2018510463 A JP2018510463 A JP 2018510463A JP 2018510463 A JP2018510463 A JP 2018510463A JP 6859323 B2 JP6859323 B2 JP 6859323B2
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- 0 CCC(C(C)CC(C)(*)C1)[C@@]1C(N=CCC)=CC(C)=* Chemical compound CCC(C(C)CC(C)(*)C1)[C@@]1C(N=CCC)=CC(C)=* 0.000 description 9
- OCWBRFAYFDUWQX-UHFFFAOYSA-N CC(C(C)=C1)N(C)N=C1[IH]C Chemical compound CC(C(C)=C1)N(C)N=C1[IH]C OCWBRFAYFDUWQX-UHFFFAOYSA-N 0.000 description 1
- SGNXEYJFIAYHEK-UHFFFAOYSA-N CC(C)[n]1c2cc(C#N)cc(-c(cc3)cc(O)c3C(O)=O)c2cc1 Chemical compound CC(C)[n]1c2cc(C#N)cc(-c(cc3)cc(O)c3C(O)=O)c2cc1 SGNXEYJFIAYHEK-UHFFFAOYSA-N 0.000 description 1
- OTGSEEQDBWACDY-UHFFFAOYSA-N C[n](c(C(F)(F)F)c1)c(c(-c(cc2)cc(O)c2C(O)=O)c2)c1cc2C#N Chemical compound C[n](c(C(F)(F)F)c1)c(c(-c(cc2)cc(O)c2C(O)=O)c2)c1cc2C#N OTGSEEQDBWACDY-UHFFFAOYSA-N 0.000 description 1
- POGUKUVJIHQIRT-UHFFFAOYSA-N N#Cc1cc([o]c(Cl)c2)c2c(-c(cc2)cc(O)c2C(O)=O)c1 Chemical compound N#Cc1cc([o]c(Cl)c2)c2c(-c(cc2)cc(O)c2C(O)=O)c1 POGUKUVJIHQIRT-UHFFFAOYSA-N 0.000 description 1
- NHTFIFUIBRGUPJ-UHFFFAOYSA-N [O-][N+](c(cc1-c(cc2)cc(O)c2C(O)=O)cc2c1[o]cc2)=O Chemical compound [O-][N+](c(cc1-c(cc2)cc(O)c2C(O)=O)cc2c1[o]cc2)=O NHTFIFUIBRGUPJ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
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- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510560190.7 | 2015-09-02 | ||
| CN201510560190 | 2015-09-02 | ||
| PCT/CN2016/097660 WO2017036404A1 (en) | 2015-09-02 | 2016-08-31 | Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof |
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| Publication Number | Publication Date |
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| JP2018532698A JP2018532698A (ja) | 2018-11-08 |
| JP2018532698A5 JP2018532698A5 (https=) | 2019-10-10 |
| JP6859323B2 true JP6859323B2 (ja) | 2021-04-14 |
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| US (1) | US10266496B2 (https=) |
| EP (1) | EP3344604B1 (https=) |
| JP (1) | JP6859323B2 (https=) |
| KR (1) | KR102635986B1 (https=) |
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| AU (1) | AU2016316278B2 (https=) |
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Families Citing this family (16)
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| WO2018157801A1 (zh) * | 2017-02-28 | 2018-09-07 | 广东东阳光药业有限公司 | 氰基取代的稠合双环衍生物及其制备方法和用途 |
| ES2639863B1 (es) * | 2017-03-10 | 2018-09-20 | Universidad De Granada | Compuestos para el tratamiento de enfermedades causadas por la acumulación de oxalato |
| WO2019057946A1 (en) | 2017-09-25 | 2019-03-28 | F. Hoffmann-La Roche Ag | MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS |
| CN109503513B (zh) * | 2018-12-29 | 2020-09-25 | 嘉实(湖南)医药科技有限公司 | 一种非布司他中间体的“一锅法”合成方法 |
| CN111943957B (zh) * | 2019-05-17 | 2023-01-06 | 中国医学科学院药物研究所 | 喹啉甲酰胺类化合物及其制备方法和用途 |
| AU2020374919B9 (en) * | 2019-10-30 | 2024-02-29 | Tonghua Dongbao Pharmaceutical Co., Ltd. | Thiophene derivatives as xanthine oxidase inhibitors and application thereof |
| WO2021204884A1 (de) * | 2020-04-09 | 2021-10-14 | Bayer Aktiengesellschaft | 3-(4-alkenyl-phenyl)-3-pyrrolin-2-one und deren verwendung als herbizide |
| CN113105481A (zh) * | 2021-02-25 | 2021-07-13 | 浙江农林大学暨阳学院 | 一种双金属催化制备苯并-6,8-二氢异喹啉-1-亚硒砜基苯甲酰胺类化合物的方法 |
| AU2022265937B2 (en) * | 2021-04-29 | 2025-04-17 | Tonghua Dongbao Pharmaceutical Co., Ltd. | Crystal form of thiophene derivative and preparation method therefor |
| JP2025515359A (ja) * | 2022-04-27 | 2025-05-14 | 杭州新元素▲薬▼▲業▼有限公司 | 痛風に用いられる化合物 |
| CN116715633B (zh) * | 2022-04-27 | 2025-08-12 | 杭州新元素药业股份有限公司 | 可用于降尿酸的化合物 |
| CN115417804A (zh) * | 2022-09-16 | 2022-12-02 | 天津药明康德新药开发有限公司 | 一种7-甲基-1h-吲哚-5-羧酸的合成方法 |
| CN116375603A (zh) * | 2023-03-03 | 2023-07-04 | 大连理工大学 | 一种合成苯丙环丁烯衍生物的方法 |
| CN118063418A (zh) * | 2024-02-27 | 2024-05-24 | 无锡捷化医药科技有限公司 | 一种2-甲基-7-硝基苯并呋喃-4-甲酸的制备方法 |
| WO2025223330A1 (zh) * | 2024-04-23 | 2025-10-30 | 深壶制药(山东)有限公司 | 吲哚并饱和环类化合物或其衍生物及其应用 |
| CN119492694B (zh) * | 2024-11-12 | 2025-09-30 | 科顺防水科技股份有限公司 | 化学阻根剂手性分布的测量方法 |
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| AU642743B2 (en) | 1990-05-21 | 1993-10-28 | Smith Kline & French Laboratories Limited | Phenol and pyridinol derivatives as pharmaceuticals |
| DK0513379T3 (da) * | 1990-11-30 | 1996-09-30 | Teijin Ltd | 2-Arylthiazolderivater og farmaceutisk præparat indeholdende sådanne |
| US8003647B2 (en) | 2007-04-11 | 2011-08-23 | Kissei Pharmaceutical Co., Ltd. | (Aza)indole derivative and use thereof for medical purposes |
| AU2009304713B2 (en) * | 2008-10-15 | 2013-10-31 | Kissei Pharmaceutical Co., Ltd. | Fused-ring derivative and medical application of same |
| EP2338887A4 (en) * | 2008-10-15 | 2012-05-09 | Kissei Pharmaceutical | FUSIONED HETEROCYCLIC DERIVATIVE AND ITS USE FOR MEDICAL PURPOSES |
| WO2010093191A2 (en) * | 2009-02-13 | 2010-08-19 | Lg Life Sciences Ltd. | Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same |
| SI2415771T1 (sl) | 2009-03-31 | 2013-12-31 | Kissei Pharmaceutical Co., Ltd. | Derivat indolizina in njegova uporaba v medicinske namene |
| TWI423962B (zh) * | 2009-10-07 | 2014-01-21 | Lg Life Sciences Ltd | 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物 |
| ES2549926T3 (es) | 2010-09-29 | 2015-11-03 | Kissei Pharmaceutical Co., Ltd. | Derivados (aza)indolizínicos como inhibidores de la xantina-oxidasa |
| CN105308040B (zh) | 2013-06-21 | 2019-06-04 | 默克专利股份公司 | 1,3-二氨基环戊烷甲酰胺衍生物 |
| JP2015214527A (ja) * | 2014-05-13 | 2015-12-03 | 帝人ファーマ株式会社 | イミダゾール誘導体 |
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| MX2018002658A (es) | 2018-06-20 |
| AU2016316278A1 (en) | 2018-03-01 |
| AR105893A1 (es) | 2017-11-22 |
| ES2839201T3 (es) | 2021-07-05 |
| DK3344604T3 (da) | 2020-12-07 |
| CA2994336C (en) | 2024-03-05 |
| WO2017036404A1 (en) | 2017-03-09 |
| HK1250982A1 (en) | 2019-01-18 |
| RU2018111106A (ru) | 2019-10-07 |
| KR102635986B1 (ko) | 2024-02-08 |
| JP2018532698A (ja) | 2018-11-08 |
| RU2018111106A3 (https=) | 2019-11-11 |
| RU2733750C2 (ru) | 2020-10-06 |
| EP3344604B1 (en) | 2020-11-04 |
| EP3344604A1 (en) | 2018-07-11 |
| HUE052608T2 (hu) | 2021-05-28 |
| CA2994336A1 (en) | 2017-03-09 |
| TW201710236A (zh) | 2017-03-16 |
| AU2016316278B2 (en) | 2020-06-04 |
| TWI733692B (zh) | 2021-07-21 |
| US10266496B2 (en) | 2019-04-23 |
| CN106478500B (zh) | 2020-02-11 |
| EP3344604A4 (en) | 2019-02-06 |
| US20180230102A1 (en) | 2018-08-16 |
| KR20180041747A (ko) | 2018-04-24 |
| CN106478500A (zh) | 2017-03-08 |
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