MX2018002658A - Derivados del anillo (hetero) aromatico sustituidos con carboxi, su metodo de preparacion y sus usos. - Google Patents
Derivados del anillo (hetero) aromatico sustituidos con carboxi, su metodo de preparacion y sus usos.Info
- Publication number
- MX2018002658A MX2018002658A MX2018002658A MX2018002658A MX2018002658A MX 2018002658 A MX2018002658 A MX 2018002658A MX 2018002658 A MX2018002658 A MX 2018002658A MX 2018002658 A MX2018002658 A MX 2018002658A MX 2018002658 A MX2018002658 A MX 2018002658A
- Authority
- MX
- Mexico
- Prior art keywords
- hetero
- preparation
- aromatic ring
- compounds
- ring derivatives
- Prior art date
Links
- 125000005842 heteroatom Chemical group 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 title 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 101000796092 Arabidopsis thaliana Sodium-dependent phosphate transport protein 1, chloroplastic Proteins 0.000 abstract 1
- 101001094043 Homo sapiens Solute carrier family 26 member 6 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102100035281 Solute carrier family 26 member 6 Human genes 0.000 abstract 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract 1
- 108010093894 Xanthine oxidase Proteins 0.000 abstract 1
- 102100033220 Xanthine oxidase Human genes 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940116269 uric acid Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510560190 | 2015-09-02 | ||
| PCT/CN2016/097660 WO2017036404A1 (en) | 2015-09-02 | 2016-08-31 | Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof |
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| ES2639863B1 (es) * | 2017-03-10 | 2018-09-20 | Universidad De Granada | Compuestos para el tratamiento de enfermedades causadas por la acumulación de oxalato |
| WO2019057946A1 (en) | 2017-09-25 | 2019-03-28 | F. Hoffmann-La Roche Ag | MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS |
| CN109503513B (zh) * | 2018-12-29 | 2020-09-25 | 嘉实(湖南)医药科技有限公司 | 一种非布司他中间体的“一锅法”合成方法 |
| CN111943957B (zh) * | 2019-05-17 | 2023-01-06 | 中国医学科学院药物研究所 | 喹啉甲酰胺类化合物及其制备方法和用途 |
| AU2020374919B9 (en) * | 2019-10-30 | 2024-02-29 | Tonghua Dongbao Pharmaceutical Co., Ltd. | Thiophene derivatives as xanthine oxidase inhibitors and application thereof |
| WO2021204884A1 (de) * | 2020-04-09 | 2021-10-14 | Bayer Aktiengesellschaft | 3-(4-alkenyl-phenyl)-3-pyrrolin-2-one und deren verwendung als herbizide |
| CN113105481A (zh) * | 2021-02-25 | 2021-07-13 | 浙江农林大学暨阳学院 | 一种双金属催化制备苯并-6,8-二氢异喹啉-1-亚硒砜基苯甲酰胺类化合物的方法 |
| EP4332097A4 (en) * | 2021-04-29 | 2025-04-23 | Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. | CRYSTAL FORM OF A THIOPHENE DERIVATIVE AND PRODUCTION METHOD THEREOF |
| CN116715633B (zh) * | 2022-04-27 | 2025-08-12 | 杭州新元素药业股份有限公司 | 可用于降尿酸的化合物 |
| WO2023208103A1 (zh) * | 2022-04-27 | 2023-11-02 | 江苏新元素医药科技有限公司 | 可用于痛风的化合物 |
| CN115417804A (zh) * | 2022-09-16 | 2022-12-02 | 天津药明康德新药开发有限公司 | 一种7-甲基-1h-吲哚-5-羧酸的合成方法 |
| CN116375603A (zh) * | 2023-03-03 | 2023-07-04 | 大连理工大学 | 一种合成苯丙环丁烯衍生物的方法 |
| CN118063418A (zh) * | 2024-02-27 | 2024-05-24 | 无锡捷化医药科技有限公司 | 一种2-甲基-7-硝基苯并呋喃-4-甲酸的制备方法 |
| CN120682237B (zh) * | 2024-04-23 | 2026-02-10 | 深壶制药(山东)有限公司 | 吲哚并饱和环类化合物或其衍生物及其应用 |
| CN119492694B (zh) * | 2024-11-12 | 2025-09-30 | 科顺防水科技股份有限公司 | 化学阻根剂手性分布的测量方法 |
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| IE911704A1 (en) | 1990-05-21 | 1991-12-04 | Smith Kline French Lab | Chemical compounds |
| ES2092580T3 (es) * | 1990-11-30 | 1996-12-01 | Teijin Ltd | Derivado de 2-ariltiazol y composicion farmaceutica que contiene el mismo. |
| JP5330989B2 (ja) | 2007-04-11 | 2013-10-30 | キッセイ薬品工業株式会社 | (アザ)インドール誘導体及びその医薬用途 |
| AU2009304713B2 (en) | 2008-10-15 | 2013-10-31 | Kissei Pharmaceutical Co., Ltd. | Fused-ring derivative and medical application of same |
| CA2739058A1 (en) * | 2008-10-15 | 2010-04-22 | Kissei Pharmaceutical Co., Ltd. | Fused heterocyclic derivative and use thereof for medical purposes |
| KR20100092909A (ko) * | 2009-02-13 | 2010-08-23 | 주식회사 엘지생명과학 | 잔틴 옥시다제 저해제로서 효과적인 신규 화합물, 그 제조방법 및 그를 함유하는 약제학적 조성물 |
| AU2010231615B2 (en) | 2009-03-31 | 2014-05-15 | Kissei Pharmaceutical Co., Ltd. | Indolizine derivative and use thereof for medical purposes |
| TWI423962B (zh) * | 2009-10-07 | 2014-01-21 | Lg Life Sciences Ltd | 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物 |
| KR20130099064A (ko) | 2010-09-29 | 2013-09-05 | 깃세이 야쿠힌 고교 가부시키가이샤 | (아자)인돌리진 유도체 및 그 의약용도 |
| AU2014283774B2 (en) | 2013-06-21 | 2018-03-01 | Merck Patent Gmbh | 1,3-diaminocyclopentane carboxamide derivatives |
| JP2015214527A (ja) * | 2014-05-13 | 2015-12-03 | 帝人ファーマ株式会社 | イミダゾール誘導体 |
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