JP6858181B2 - 免疫チェックポイントブロッカーを用いる治療の臨床アウトカムを予測するための診断マーカーとしてのｇｄｆ−１５ - Google Patents

免疫チェックポイントブロッカーを用いる治療の臨床アウトカムを予測するための診断マーカーとしてのｇｄｆ−１５ Download PDF

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JP6858181B2
JP6858181B2 JP2018516740A JP2018516740A JP6858181B2 JP 6858181 B2 JP6858181 B2 JP 6858181B2 JP 2018516740 A JP2018516740 A JP 2018516740A JP 2018516740 A JP2018516740 A JP 2018516740A JP 6858181 B2 JP6858181 B2 JP 6858181B2
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hgdf
cancer
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イェルク・ヴィッシュフーゼン
マルクス・ハーケ
ラインハルト・ドゥマー
マティアス・メーリング
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ユリウス−マクシミリアン−ウニヴェルシテート・ヴュルツブルク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • G—PHYSICS
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    • G01N21/64—Fluorescence; Phosphorescence
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/495—Transforming growth factor [TGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2018516740A 2015-10-02 2016-09-30 免疫チェックポイントブロッカーを用いる治療の臨床アウトカムを予測するための診断マーカーとしてのｇｄｆ−１５ Active JP6858181B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1517527.6 2015-10-02
GBGB1517527.6A GB201517527D0 (en) 2015-10-02 2015-10-02 GDF-15 as a diagnosis marker to predict the clinical outcome of a treatment with immune checkpoint blockers
GB1607800.8 2016-04-29
GBGB1607800.8A GB201607800D0 (en) 2016-04-29 2016-04-29 GDF-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers
PCT/EP2016/073519 WO2017055612A1 (en) 2015-10-02 2016-09-30 Gdf-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers

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JP2018535404A JP2018535404A (ja) 2018-11-29
JP2018535404A5 JP2018535404A5 (OSRAM) 2021-01-21
JP6858181B2 true JP6858181B2 (ja) 2021-04-14

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US (2) US11262360B2 (OSRAM)
EP (2) EP4321866A3 (OSRAM)
JP (1) JP6858181B2 (OSRAM)
KR (1) KR102621034B1 (OSRAM)
AU (1) AU2016333538B2 (OSRAM)
CA (1) CA3000290C (OSRAM)
DK (1) DK3356827T3 (OSRAM)
ES (1) ES2968226T3 (OSRAM)
FI (1) FI3356827T3 (OSRAM)
WO (1) WO2017055612A1 (OSRAM)

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US11262360B2 (en) 2022-03-01
JP2018535404A (ja) 2018-11-29
US12473354B2 (en) 2025-11-18
EP4321866A3 (en) 2024-03-20
EP3356827A1 (en) 2018-08-08
AU2016333538A1 (en) 2018-04-26
FI3356827T3 (fi) 2024-01-03
US20220242942A1 (en) 2022-08-04
WO2017055612A1 (en) 2017-04-06
KR20180054867A (ko) 2018-05-24
ES2968226T3 (es) 2024-05-08
EP3356827B1 (en) 2023-12-06
AU2016333538B2 (en) 2022-03-31
DK3356827T3 (da) 2024-01-08
CA3000290C (en) 2023-02-21
CA3000290A1 (en) 2017-04-06
KR102621034B1 (ko) 2024-01-03
EP4321866A2 (en) 2024-02-14
US20180292412A1 (en) 2018-10-11

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