JP2018535404A5 - - Google Patents
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- JP2018535404A5 JP2018535404A5 JP2018516740A JP2018516740A JP2018535404A5 JP 2018535404 A5 JP2018535404 A5 JP 2018535404A5 JP 2018516740 A JP2018516740 A JP 2018516740A JP 2018516740 A JP2018516740 A JP 2018516740A JP 2018535404 A5 JP2018535404 A5 JP 2018535404A5
- Authority
- JP
- Japan
- Prior art keywords
- hgdf
- cancer
- detection kit
- level
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1517527.6 | 2015-10-02 | ||
| GBGB1517527.6A GB201517527D0 (en) | 2015-10-02 | 2015-10-02 | GDF-15 as a diagnosis marker to predict the clinical outcome of a treatment with immune checkpoint blockers |
| GB1607800.8 | 2016-04-29 | ||
| GBGB1607800.8A GB201607800D0 (en) | 2016-04-29 | 2016-04-29 | GDF-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers |
| PCT/EP2016/073519 WO2017055612A1 (en) | 2015-10-02 | 2016-09-30 | Gdf-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535404A JP2018535404A (ja) | 2018-11-29 |
| JP2018535404A5 true JP2018535404A5 (OSRAM) | 2021-01-21 |
| JP6858181B2 JP6858181B2 (ja) | 2021-04-14 |
Family
ID=57123979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516740A Active JP6858181B2 (ja) | 2015-10-02 | 2016-09-30 | 免疫チェックポイントブロッカーを用いる治療の臨床アウトカムを予測するための診断マーカーとしてのｇｄｆ−１５ |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11262360B2 (OSRAM) |
| EP (2) | EP4321866A3 (OSRAM) |
| JP (1) | JP6858181B2 (OSRAM) |
| KR (1) | KR102621034B1 (OSRAM) |
| AU (1) | AU2016333538B2 (OSRAM) |
| CA (1) | CA3000290C (OSRAM) |
| DK (1) | DK3356827T3 (OSRAM) |
| ES (1) | ES2968226T3 (OSRAM) |
| FI (1) | FI3356827T3 (OSRAM) |
| WO (1) | WO2017055612A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013322628B2 (en) * | 2012-09-26 | 2017-03-02 | Julius-Maximilians-Universitat Wurzburg | Monoclonal antibodies to growth and differentiation factor 15 (GDF-15) |
| US10509045B2 (en) | 2015-05-29 | 2019-12-17 | University Of Florida Research Foundation, Incorporated | Methods for diagnosing Huntington's disease |
| DK3356827T3 (da) | 2015-10-02 | 2024-01-08 | Univ Wuerzburg J Maximilians | Gdf-15 som en diagnostisk markør til forudsigelse af det kliniske resultat af en behandling med immun-checkpoint-blokkere |
| CA3019847A1 (en) | 2016-04-04 | 2017-10-12 | University Of Florida Research Foundation, Incorporated | Manipulation of eif3 to modulate repeat associated non-atg (ran) translation |
| BR112018072034A2 (pt) | 2016-05-24 | 2019-02-12 | Novo Nordisk A/S | compostos mic-1 e usos dos mesmos |
| AU2018255293B2 (en) | 2017-04-17 | 2024-03-07 | University Of Florida Research Foundation, Incorporated | Regulation of RAN translation by PKR and eIF2a-P pathways |
| TWI710377B (zh) | 2017-05-23 | 2020-11-21 | 丹麥商諾佛 儂迪克股份有限公司 | Ｍｉｃ－１化合物及其用途 |
| AU2018338451A1 (en) | 2017-09-25 | 2020-04-02 | University Of Florida Research Foundation, Incorporated | Immunoassays for detection of RAN proteins |
| CA3128973A1 (en) | 2019-03-04 | 2020-09-10 | Bhaskar Bhattacharyya | Data compression and communication using machine learning |
| KR102164432B1 (ko) | 2019-09-18 | 2020-10-13 | 한국과학기술원 | Dna 메틸화 변이를 이용한 면역항암치료 반응성 예측방법 |
| CA3154741A1 (en) | 2019-09-20 | 2021-03-25 | University Of Florida Research Foundation, Incorporated | Detection of antibodies against ran proteins from serum and tissue lysates |
| KR102238912B1 (ko) | 2020-05-27 | 2021-04-12 | 한국과학기술원 | Dna 메틸화 변이 및 종양 변이 부담을 이용한 면역항암치료 반응성 예측방법 |
| CN112162097B (zh) * | 2020-07-24 | 2022-04-01 | 广州医科大学 | Gdf1作为评估pd-1单抗治疗效果的生物标志物 |
| KR20230107309A (ko) | 2020-11-10 | 2023-07-14 | 카탈임 게엠베하 | 항-gdf15 항체 및 암 치료용 투여 용법 |
| CN112698042A (zh) * | 2020-12-17 | 2021-04-23 | 北京赛诺浦生物技术有限公司 | 检测人生长分化因子-15的荧光免疫层析试纸条及其制备方法和应用 |
| CN113252905A (zh) * | 2021-05-12 | 2021-08-13 | 北京赛诺浦生物技术有限公司 | 人生长分化因子-15磁微粒化学发光检测试剂盒及其应用 |
| CN113702647B (zh) * | 2021-08-31 | 2024-03-15 | 普十生物科技(北京)有限公司 | 人生长分化因子15即时检测试剂盒、其制备方法及其应用 |
| KR20230046264A (ko) | 2021-09-29 | 2023-04-05 | (주)펜타메딕스 | Line-1의 dna 메틸화 변이를 이용한 면역항암치료 반응성 예측방법 |
| CN115831306A (zh) * | 2023-02-23 | 2023-03-21 | 北京康博众联电子科技有限公司 | 一种数据分析装置、方法及计算机存储介质 |
| CN116462757A (zh) * | 2023-03-24 | 2023-07-21 | 科兴生物制药股份有限公司 | Gdf15的单域抗体及其应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US6455677B1 (en) | 1998-04-30 | 2002-09-24 | Boehringer Ingelheim International Gmbh | FAPα-specific antibody with improved producibility |
| US6465181B2 (en) | 1999-03-25 | 2002-10-15 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the prostate |
| ES2275513T3 (es) | 1999-05-17 | 2007-06-16 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum Vertrieb Von Pharmaka Mbh | Propiedades neuroprotectoras de gdf-15, un miembro de la superfamilia de tgf-beta. |
| WO2002020759A2 (en) | 2000-09-08 | 2002-03-14 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties |
| AU2005205533B2 (en) | 2004-01-07 | 2012-03-22 | Novartis Vaccines And Diagnostics, Inc. | M-CSF-specific monoclonal antibody and uses thereof |
| US8192735B2 (en) | 2004-04-13 | 2012-06-05 | St Vincent's Hospital Sydney Limited | Method for modulating appetite |
| WO2007067500A2 (en) | 2005-12-05 | 2007-06-14 | Genomic Health, Inc. | Predictors of patient response to treatment with egfr inhibitors |
| CN101854947A (zh) | 2007-08-16 | 2010-10-06 | 圣文森特医院悉尼有限公司 | 用于调节巨噬细胞抑制因子(mic-1)活性的药剂和方法 |
| WO2009046495A1 (en) | 2007-10-09 | 2009-04-16 | St Vincent's Hospital Sydney Limited | A method of treating cachexia with the removal or inactivation of macrophage inhibitory cytokine-1 |
| WO2009150255A2 (en) * | 2008-06-13 | 2009-12-17 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Markers for predicting response and survival in anti-egfr treated patients |
| BRPI0919531A2 (pt) | 2008-09-29 | 2015-12-08 | Roche Glycart Ag | anticorpos contra il17 humana e usos dos mesmos |
| EP2209003A1 (en) * | 2009-01-16 | 2010-07-21 | F. Hoffmann-Roche AG | Means and methods for differentiating between fibrosis and cirrhosis |
| US7736861B1 (en) * | 2009-10-19 | 2010-06-15 | Aveo Pharmaceuticals, Inc. | Tivozanib response prediction |
| US20120309697A1 (en) | 2009-10-28 | 2012-12-06 | Samuel Norbert Breit | Methods of diagnosing and prognosing colonic polyps |
| US9212221B2 (en) | 2010-03-03 | 2015-12-15 | Detroit R & D, Inc. | Form-specific antibodies for NAG-1 (MIC-1, GDF-15), H6D and other TGF-β subfamily and heart disease and cancer diagnoses |
| WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| MX355060B (es) | 2010-11-17 | 2018-04-03 | Chugai Pharmaceutical Co Ltd | Molecula multiespecifica de union a antigeno que tiene funcion alternativa a la funcion del factor viii de coagulacion sanguinea. |
| ES2704038T3 (es) * | 2011-05-24 | 2019-03-13 | Zyngenia Inc | Complejos multiespecíficos multivalentes y monovalentes y sus usos |
| WO2013012648A1 (en) | 2011-07-15 | 2013-01-24 | Emory University | Gdf15 in diagnostic and therapeutic applications |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| CN102321173B (zh) | 2011-08-12 | 2013-04-03 | 中国医学科学院肿瘤研究所 | 人源化巨噬细胞抑制因子1单克隆抗体及其应用 |
| EP2565262A1 (en) | 2011-08-31 | 2013-03-06 | VTU Holding GmbH | Protein expression |
| BR112014018575A2 (pt) | 2012-01-26 | 2017-07-04 | Amgen Inc | polipetídeos de fator de diferenciação de crescimento 15 (gdf-15) |
| AU2013322628B2 (en) | 2012-09-26 | 2017-03-02 | Julius-Maximilians-Universitat Wurzburg | Monoclonal antibodies to growth and differentiation factor 15 (GDF-15) |
| CN105073133B (zh) | 2012-12-21 | 2021-04-20 | Aveo制药公司 | 抗gdf15抗体 |
| CA2906523A1 (en) * | 2013-03-15 | 2014-09-25 | Myriad Genetics, Inc. | Genes and gene signatures for diagnosis and treatment of melanoma |
| JP2015078138A (ja) | 2013-10-15 | 2015-04-23 | 株式会社ニックス | 小動物防除性樹脂組成物 |
| AU2015206603B9 (en) * | 2014-01-14 | 2019-07-18 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for identification, assessment, prevention, and treatment of melanoma using PD-L1 isoforms |
| EP2899544B1 (en) * | 2014-01-28 | 2018-12-26 | Roche Diagnostics GmbH | Biomarkers for risk assessment and treatment monitoring in heart failure patients who receive B-type natriuretic peptide guided therapy |
| SI3134123T1 (sl) | 2014-02-21 | 2021-08-31 | Nektar Therapeutics (India) Pvt. Ltd. | IL-2Rbeta-selektivni agonisti v kombinaciji s protitelesom proti- CTLA-4 ali protitelesom proti-PD-1 |
| DK3122775T3 (da) | 2014-03-26 | 2020-02-03 | Univ Wuerzburg J Maximilians | Monoklonale antistoffer til vækst- og differentieringsfaktor 15 (gdf-15), og anvendelser deraf til behandling af cancer kakeksi og cancer |
| EP3851122A1 (en) | 2014-09-25 | 2021-07-21 | Aveo Pharmaceuticals Inc. | Methods of reversing cachexia and prolonging survival comprising administering a gdf15 modulator and an anti-cancer agent |
| DK3356827T3 (da) | 2015-10-02 | 2024-01-08 | Univ Wuerzburg J Maximilians | Gdf-15 som en diagnostisk markør til forudsigelse af det kliniske resultat af en behandling med immun-checkpoint-blokkere |
| PT3355919T (pt) | 2015-10-02 | 2023-01-06 | Univ Wuerzburg J Maximilians | Terapia de combinação utilizando inibidores do fator de crescimento e diferenciação 15 (gdf-15) humano e bloqueadores de pontos de controlo imunitários |
| GB201517528D0 (en) | 2015-10-02 | 2015-11-18 | Julius Maximillians Universitãt Würzburg | GDF-15 as a diagnosis marker for melanoma |
| EP3841121A2 (en) | 2018-08-20 | 2021-06-30 | Pfizer Inc. | Anti-gdf15 antibodies, compositions and methods of use |
-
2016
- 2016-09-30 DK DK16779036.9T patent/DK3356827T3/da active
- 2016-09-30 JP JP2018516740A patent/JP6858181B2/ja active Active
- 2016-09-30 EP EP23206060.8A patent/EP4321866A3/en not_active Withdrawn
- 2016-09-30 AU AU2016333538A patent/AU2016333538B2/en active Active
- 2016-09-30 CA CA3000290A patent/CA3000290C/en active Active
- 2016-09-30 FI FIEP16779036.9T patent/FI3356827T3/fi active
- 2016-09-30 EP EP16779036.9A patent/EP3356827B1/en active Active
- 2016-09-30 WO PCT/EP2016/073519 patent/WO2017055612A1/en not_active Ceased
- 2016-09-30 US US15/765,174 patent/US11262360B2/en active Active
- 2016-09-30 ES ES16779036T patent/ES2968226T3/es active Active
- 2016-09-30 KR KR1020187012419A patent/KR102621034B1/ko active Active
-
2022
- 2022-01-20 US US17/580,245 patent/US12473354B2/en active Active
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