JP6847654B2 - 口腔用及び/又は咽喉用組成物 - Google Patents
口腔用及び/又は咽喉用組成物 Download PDFInfo
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- JP6847654B2 JP6847654B2 JP2016248135A JP2016248135A JP6847654B2 JP 6847654 B2 JP6847654 B2 JP 6847654B2 JP 2016248135 A JP2016248135 A JP 2016248135A JP 2016248135 A JP2016248135 A JP 2016248135A JP 6847654 B2 JP6847654 B2 JP 6847654B2
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Images
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Description
項1.
(a)塩化セチルピリジニウムを0.05〜0.8質量%、
(b)グリセリンを35質量%以上、
(c)ソルビトールを0.5〜30質量%、
(d)l−メントールを0.05〜0.25質量%、
(e)1,8−シネオールを0.0004〜0.09質量%、並びに
(f)オイゲノール、グアイアコール、エチルグアイアコール、メチルオイゲノール、及びチモールからなる群より選択される少なくとも1種を0.0002〜0.08質量%
含有し、
且つ、(b)グリセリンと(c)ソルビトールの合計含有量が48〜90質量%である、
口腔用及び/又は咽喉用組成物。
項2.
(b)グリセリンを35〜80質量%、(c)ソルビトールを3〜30質量%、含有する、項1に記載の口腔用及び/又は咽喉用組成物
項3.
(b)グリセリンの含有量をB質量%、(c)ソルビトールの含有量をC質量%としたとき、
1.2≦B/C≦23である、項1又は2に記載の口腔用及び/又は咽喉用組成物。
項4.
液体組成物である、項1〜3のいずれかに記載の口腔用及び/又は咽喉用組成物。
項5.
スプレー用組成物である、項1〜4のいずれかに記載の口腔用及び/又は咽喉用組成物。
表1〜6に記載の組成に従い、各種成分を混合して、口腔用及び/又は咽喉用組成物を調製した。なお、ソルビトールを組成物に含有させるために、原料としてソルビトール液(ソルビトール70質量%水溶液)を用いた。従って、表に記載されるソルビトール液の使用量に0.7を乗じることで、各組成物に含まれるソルビトール量を算出できる。
ディスペンサー部(ポンプ部)
1プッシュ用量(1プッシュで噴霧される量):約0.07〜0.11mL
ノズル孔径:約0.3mm
ボトル部
容量:約20mL
高さ:約62mm
直径:約24mm
材質:PP(ポリプロピレン)
パネラー5人に対して、調製した各組成物を喉及び口腔内に4プッシュして適用し、使用直後の咽喉および舌の付け根の奥に感じる苦味、刺激性、及びさっぱり感を評価した。各評価項目の評価基準(数値)及び判定基準を次に示す。なお、表1〜6に示す評価数値は、5人のパネラーの評価数値の平均値である。
0:苦味なし
1:ほとんど苦味なし
2:わずかに苦味あり
3:苦味あり
4:非常に苦味あり
◎:2点未満
○:2点以上3点未満
×:3点以上
0:刺激なし
1:ほとんど刺激なし
2:わずかに刺激あり
3:刺激あり
4:非常に刺激あり
◎:2点未満
○:2点以上3点未満
×:3点以上
0:全くさっぱりしない
1:ほとんどさっぱりしない
2:ややさっぱりする
3:さっぱりする
4:非常にさっぱりする
◎:3点以上
○:2点以上3点未満
×:2点未満
調製した各組成物をスプレー容器に充填した状態で、−5℃の温度条件下に1週間放置し、性状を以下の基準で目視評価した。
−:無色透明で析出物は認められない
+:析出物又はおりが認められる
調製した各組成物をスプレー容器に充填した状態で、55℃の温度条件下に1ヶ月放置し、性状を以下の基準で目視評価した。
−:無色透明で変色は認められない
+:渇変し黄色味を帯びている
調製した各組成物をスプレー容器に充填した状態で、55℃の温度条件下に1ヶ月放置した。容器を正立させて、室温(20℃)で5cmの距離からろ紙に1プッシュしたときの吐出パターンの直径を評価した。当該評価についての概要を図1に示す。
×:40mmを超える、又は10mm未満もしくは吐出しない
○:10mm以上40mm以下
*口腔と喉両方への適応を考えると15mm以上35mm以下がより好ましい。
特に好ましい参考例の一つである、参考例7をベースとして、さらに薬用感及び嗜好性にも優れる組成物を得るため、さらにオイゲノール等を追加し、同様にして検討を行った。ただ、「香料」については、上記(f)成分がほとんど含まれないものを使用した。具体的には、表7に記載の組成に従い、各種成分を混合して、口腔用及び/又は咽喉用組成物を調製し、各組成物を上記と同様に評価した。評価結果を表7に併せて示す。なお、上記と同様、ソルビトールを組成物に含有させるために、原料としてソルビトール液(ソルビトール70質量%水溶液)を用いた。従って、表に記載されるソルビトール液の使用量に0.7を乗じることで、各組成物に含まれるソルビトール量を算出できる。
0:全く感じられない
1:ほとんど感じられない
2:やや感じられる
3:感じられる
4:非常に感じられる
◎:3点以上
○:2点以上3点未満
×:2点未満
0:非常に悪い
1:悪い
2:どちらともいえない
3:良い
4:非常に良い
◎:3点以上
○:2点以上3点未満
×:2点未満
Claims (5)
- (a)塩化セチルピリジニウムを0.05〜0.8質量%、
(b)グリセリンを35質量%以上、
(c)ソルビトールを0.5〜30質量%、
(d)l−メントールを0.05〜0.25質量%、
(e)1,8−シネオールを0.0004〜0.09質量%、並びに
(f)オイゲノール、グアイアコール、エチルグアイアコール、メチルオイゲノール、及びチモールからなる群より選択される少なくとも1種を0.0002〜0.08質量%
含有し、
且つ、(b)グリセリンと(c)ソルビトールの合計含有量が48〜90質量%である、
口腔用及び/又は咽喉用組成物。 - (b)グリセリンを35〜80質量%、(c)ソルビトールを3〜30質量%、含有する、請求項1に記載の口腔用及び/又は咽喉用組成物
- (b)グリセリンの含有量をB質量%、(c)ソルビトールの含有量をC質量%としたとき、
1.2≦B/C≦23である、請求項1又は2に記載の口腔用及び/又は咽喉用組成物。 - 液体組成物である、請求項1〜3のいずれかに記載の口腔用及び/又は咽喉用組成物。
- スプレー用組成物である、請求項1〜4のいずれかに記載の口腔用及び/又は咽喉用組成物。
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