JP6845012B2 - 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用 - Google Patents

遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用 Download PDF

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JP6845012B2
JP6845012B2 JP2016547570A JP2016547570A JP6845012B2 JP 6845012 B2 JP6845012 B2 JP 6845012B2 JP 2016547570 A JP2016547570 A JP 2016547570A JP 2016547570 A JP2016547570 A JP 2016547570A JP 6845012 B2 JP6845012 B2 JP 6845012B2
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antibody
binding
plasma kallikrein
antibodies
dose
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チユン,ユン
セクストン,ダニエル,ジェイ.
テンフール,クリストファー
ケニストン,ジョン,エー.
フォーセット,リヤン
イアロビノ,リヤン
ビーデンカップ,ジョセフ
アデルマン,バート
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ダイアックス コーポレーション
ダイアックス コーポレーション
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/03Phosphotransferases with a nitrogenous group as acceptor (2.7.3)
    • C12Y207/03002Creatine kinase (2.7.3.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21034Plasma kallikrein (3.4.21.34)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016547570A 2014-01-21 2015-01-21 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用 Active JP6845012B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461929716P 2014-01-21 2014-01-21
US61/929,716 2014-01-21
US201461944361P 2014-02-25 2014-02-25
US61/944,361 2014-02-25
US201462021397P 2014-07-07 2014-07-07
US62/021,397 2014-07-07
PCT/US2015/012212 WO2015112578A1 (en) 2014-01-21 2015-01-21 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema

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JP2019166361A Division JP7164502B2 (ja) 2014-01-21 2019-09-12 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用

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JP2017503820A JP2017503820A (ja) 2017-02-02
JP2017503820A5 JP2017503820A5 (cg-RX-API-DMAC7.html) 2018-03-01
JP6845012B2 true JP6845012B2 (ja) 2021-03-17

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JP2019166361A Active JP7164502B2 (ja) 2014-01-21 2019-09-12 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用
JP2022168140A Pending JP2023015087A (ja) 2014-01-21 2022-10-20 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用
JP2024151126A Pending JP2024170495A (ja) 2014-01-21 2024-09-03 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用

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JP2022168140A Pending JP2023015087A (ja) 2014-01-21 2022-10-20 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用
JP2024151126A Pending JP2024170495A (ja) 2014-01-21 2024-09-03 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用

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CN (2) CN106132442B (cg-RX-API-DMAC7.html)
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CA (1) CA2937329C (cg-RX-API-DMAC7.html)
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EA (1) EA038532B1 (cg-RX-API-DMAC7.html)
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PL (1) PL3096798T3 (cg-RX-API-DMAC7.html)
PT (1) PT3096798T (cg-RX-API-DMAC7.html)
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JP2020002171A (ja) * 2014-01-21 2020-01-09 ダイアックス コーポレーション 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用
US12084515B2 (en) 2014-03-27 2024-09-10 Takeda Pharmaceutical Company Limited Compositions and methods for treatment of diabetic macular edema
US12110343B2 (en) 2013-03-15 2024-10-08 Takeda Pharmaceutical Company Limited Anti-plasma kallikrein antibodies
US12460016B2 (en) 2010-01-06 2025-11-04 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins

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US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
BR112019005167A2 (pt) * 2016-09-16 2019-07-02 Dyax Corp. método e kit para analisar uma amostra
EP3678553B1 (en) 2017-09-05 2024-05-22 Sanolla Ltd Diagnosis of pathologies using infrasonic signatures
MX2021002349A (es) 2018-08-30 2021-05-31 Takeda Pharmaceuticals Co Inhibidores de calicreína en plasmá y usos de los mismos para tratar ataque de angioedema hereditario.
EP3938404A1 (en) 2019-03-14 2022-01-19 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
CN115297927A (zh) 2020-01-13 2022-11-04 武田药品工业株式会社 血浆激肽释放酶抑制剂及其用于治疗儿科遗传性血管性水肿发作的用途

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US12460016B2 (en) 2010-01-06 2025-11-04 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
US12110343B2 (en) 2013-03-15 2024-10-08 Takeda Pharmaceutical Company Limited Anti-plasma kallikrein antibodies
JP2020002171A (ja) * 2014-01-21 2020-01-09 ダイアックス コーポレーション 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用
JP7164502B2 (ja) 2014-01-21 2022-11-01 武田薬品工業株式会社 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用
US12384854B2 (en) 2014-01-21 2025-08-12 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema
US12084515B2 (en) 2014-03-27 2024-09-10 Takeda Pharmaceutical Company Limited Compositions and methods for treatment of diabetic macular edema

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