JP6839100B2 - 眼内レンズ材料及び部材 - Google Patents
眼内レンズ材料及び部材 Download PDFInfo
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- JP6839100B2 JP6839100B2 JP2017563993A JP2017563993A JP6839100B2 JP 6839100 B2 JP6839100 B2 JP 6839100B2 JP 2017563993 A JP2017563993 A JP 2017563993A JP 2017563993 A JP2017563993 A JP 2017563993A JP 6839100 B2 JP6839100 B2 JP 6839100B2
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- Prior art keywords
- polymer
- silicone oil
- intraocular lens
- fluid
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000463 material Substances 0.000 title claims description 89
- 229920002545 silicone oil Polymers 0.000 claims description 118
- 239000012530 fluid Substances 0.000 claims description 107
- 239000002861 polymer material Substances 0.000 claims description 21
- QTKPMCIBUROOGY-UHFFFAOYSA-N 2,2,2-trifluoroethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(F)(F)F QTKPMCIBUROOGY-UHFFFAOYSA-N 0.000 claims description 10
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 description 123
- 210000000695 crystalline len Anatomy 0.000 description 105
- 239000000203 mixture Substances 0.000 description 64
- 239000000853 adhesive Substances 0.000 description 49
- 230000001070 adhesive effect Effects 0.000 description 49
- 230000003287 optical effect Effects 0.000 description 48
- 239000000178 monomer Substances 0.000 description 41
- 238000000034 method Methods 0.000 description 35
- 238000009472 formulation Methods 0.000 description 30
- -1 diphenylsiloxane unit Chemical group 0.000 description 26
- 230000008961 swelling Effects 0.000 description 23
- 239000003921 oil Substances 0.000 description 21
- 230000004044 response Effects 0.000 description 17
- 238000004519 manufacturing process Methods 0.000 description 16
- 239000003085 diluting agent Substances 0.000 description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 14
- 238000009792 diffusion process Methods 0.000 description 13
- 210000003205 muscle Anatomy 0.000 description 13
- 230000001886 ciliary effect Effects 0.000 description 12
- 208000002177 Cataract Diseases 0.000 description 11
- 238000009826 distribution Methods 0.000 description 11
- 230000008901 benefit Effects 0.000 description 10
- NYMPGSQKHIOWIO-UHFFFAOYSA-N hydroxy(diphenyl)silicon Chemical class C=1C=CC=CC=1[Si](O)C1=CC=CC=C1 NYMPGSQKHIOWIO-UHFFFAOYSA-N 0.000 description 10
- 238000010550 living polymerization reaction Methods 0.000 description 10
- 230000002093 peripheral effect Effects 0.000 description 10
- 238000006116 polymerization reaction Methods 0.000 description 10
- 210000004240 ciliary body Anatomy 0.000 description 9
- 239000013590 bulk material Substances 0.000 description 8
- JJRDHFIVAPVZJN-UHFFFAOYSA-N cyclotrisiloxane Chemical compound O1[SiH2]O[SiH2]O[SiH2]1 JJRDHFIVAPVZJN-UHFFFAOYSA-N 0.000 description 8
- 238000001356 surgical procedure Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 102100026735 Coagulation factor VIII Human genes 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
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- 238000000605 extraction Methods 0.000 description 6
- 239000003999 initiator Substances 0.000 description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate group Chemical group C(C(=C)C)(=O)[O-] CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
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- YDGMGEXADBMOMJ-LURJTMIESA-N N(g)-dimethylarginine Chemical compound CN(C)C(\N)=N\CCC[C@H](N)C(O)=O YDGMGEXADBMOMJ-LURJTMIESA-N 0.000 description 4
- 239000006096 absorbing agent Substances 0.000 description 4
- YDGMGEXADBMOMJ-UHFFFAOYSA-N asymmetrical dimethylarginine Natural products CN(C)C(N)=NCCCC(N)C(O)=O YDGMGEXADBMOMJ-UHFFFAOYSA-N 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
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- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 3
- HPSGLFKWHYAKSF-UHFFFAOYSA-N 2-phenylethyl prop-2-enoate Chemical compound C=CC(=O)OCCC1=CC=CC=C1 HPSGLFKWHYAKSF-UHFFFAOYSA-N 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
- 125000005250 alkyl acrylate group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
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- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
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- 125000001153 fluoro group Chemical group F* 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
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- 238000010189 synthetic method Methods 0.000 description 3
- APAUNQLFVGBQQW-UHFFFAOYSA-N (1,2,2-trimethylcyclohexyl) 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1(C)CCCCC1(C)C APAUNQLFVGBQQW-UHFFFAOYSA-N 0.000 description 2
- WBHPKCUQHAQKJU-UHFFFAOYSA-N 2,5,5-trimethylhex-2-enoic acid Chemical compound OC(=O)C(C)=CCC(C)(C)C WBHPKCUQHAQKJU-UHFFFAOYSA-N 0.000 description 2
- SZZMLMZBTUOSNY-UHFFFAOYSA-N 2-(1,2,2-trimethylcyclohexyl)prop-2-enoic acid Chemical compound CC1(C)CCCCC1(C)C(=C)C(O)=O SZZMLMZBTUOSNY-UHFFFAOYSA-N 0.000 description 2
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 2
- WDQMWEYDKDCEHT-UHFFFAOYSA-N 2-ethylhexyl 2-methylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C(C)=C WDQMWEYDKDCEHT-UHFFFAOYSA-N 0.000 description 2
- RUMACXVDVNRZJZ-UHFFFAOYSA-N 2-methylpropyl 2-methylprop-2-enoate Chemical compound CC(C)COC(=O)C(C)=C RUMACXVDVNRZJZ-UHFFFAOYSA-N 0.000 description 2
- CFVWNXQPGQOHRJ-UHFFFAOYSA-N 2-methylpropyl prop-2-enoate Chemical compound CC(C)COC(=O)C=C CFVWNXQPGQOHRJ-UHFFFAOYSA-N 0.000 description 2
- BTGYQHGWZLBJOB-UHFFFAOYSA-N 3-[3-tert-butyl-5-(5-chlorobenzotriazol-2-yl)-4-hydroxyphenoxy]propyl 2-methylprop-2-enoate Chemical compound CC(C)(C)C1=CC(OCCCOC(=O)C(=C)C)=CC(N2N=C3C=C(Cl)C=CC3=N2)=C1O BTGYQHGWZLBJOB-UHFFFAOYSA-N 0.000 description 2
- ULYIFEQRRINMJQ-UHFFFAOYSA-N 3-methylbutyl 2-methylprop-2-enoate Chemical compound CC(C)CCOC(=O)C(C)=C ULYIFEQRRINMJQ-UHFFFAOYSA-N 0.000 description 2
- AKYMVBSCUAMKKW-UHFFFAOYSA-N 4,4-dimethyl-2-methylidenepentanoic acid Chemical compound CC(C)(C)CC(=C)C(O)=O AKYMVBSCUAMKKW-UHFFFAOYSA-N 0.000 description 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 2
- 239000012964 benzotriazole Substances 0.000 description 2
- AOJOEFVRHOZDFN-UHFFFAOYSA-N benzyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC1=CC=CC=C1 AOJOEFVRHOZDFN-UHFFFAOYSA-N 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
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- 238000013461 design Methods 0.000 description 2
- ZQMIGQNCOMNODD-UHFFFAOYSA-N diacetyl peroxide Chemical compound CC(=O)OOC(C)=O ZQMIGQNCOMNODD-UHFFFAOYSA-N 0.000 description 2
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- ZYMKZMDQUPCXRP-UHFFFAOYSA-N fluoro prop-2-enoate Chemical compound FOC(=O)C=C ZYMKZMDQUPCXRP-UHFFFAOYSA-N 0.000 description 2
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 2
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- NZIDBRBFGPQCRY-UHFFFAOYSA-N octyl 2-methylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C(C)=C NZIDBRBFGPQCRY-UHFFFAOYSA-N 0.000 description 2
- 238000005191 phase separation Methods 0.000 description 2
- WRAQQYDMVSCOTE-UHFFFAOYSA-N phenyl prop-2-enoate Chemical compound C=CC(=O)OC1=CC=CC=C1 WRAQQYDMVSCOTE-UHFFFAOYSA-N 0.000 description 2
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
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- BKKVYNMMVYEBGR-UHFFFAOYSA-N (2,3,4,5,6-pentabromophenyl) prop-2-enoate Chemical compound BrC1=C(Br)C(Br)=C(OC(=O)C=C)C(Br)=C1Br BKKVYNMMVYEBGR-UHFFFAOYSA-N 0.000 description 1
- NIJWSVFNELSKMF-UHFFFAOYSA-N (2,3,4,5,6-pentafluorophenyl) 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1=C(F)C(F)=C(F)C(F)=C1F NIJWSVFNELSKMF-UHFFFAOYSA-N 0.000 description 1
- RFOWDPMCXHVGET-UHFFFAOYSA-N (2,3,4,5,6-pentafluorophenyl) prop-2-enoate Chemical compound FC1=C(F)C(F)=C(OC(=O)C=C)C(F)=C1F RFOWDPMCXHVGET-UHFFFAOYSA-N 0.000 description 1
- BUPRYTFTHBNSBD-UHFFFAOYSA-N (2,3,4-tribromophenyl) prop-2-enoate Chemical compound BrC1=CC=C(OC(=O)C=C)C(Br)=C1Br BUPRYTFTHBNSBD-UHFFFAOYSA-N 0.000 description 1
- HGXJDMCMYLEZMJ-UHFFFAOYSA-N (2-methylpropan-2-yl)oxy 2,2-dimethylpropaneperoxoate Chemical compound CC(C)(C)OOOC(=O)C(C)(C)C HGXJDMCMYLEZMJ-UHFFFAOYSA-N 0.000 description 1
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- 230000003416 augmentation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- 150000001565 benzotriazoles Chemical class 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- GCTPMLUUWLLESL-UHFFFAOYSA-N benzyl prop-2-enoate Chemical compound C=CC(=O)OCC1=CC=CC=C1 GCTPMLUUWLLESL-UHFFFAOYSA-N 0.000 description 1
- QUDWYFHPNIMBFC-UHFFFAOYSA-N bis(prop-2-enyl) benzene-1,2-dicarboxylate Chemical compound C=CCOC(=O)C1=CC=CC=C1C(=O)OCC=C QUDWYFHPNIMBFC-UHFFFAOYSA-N 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 125000005587 carbonate group Chemical group 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000000068 chlorophenyl group Chemical group 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
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- 230000007423 decrease Effects 0.000 description 1
- 125000004386 diacrylate group Chemical group 0.000 description 1
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- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
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- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 description 1
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- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- WMIYKQLTONQJES-UHFFFAOYSA-N hexafluoroethane Chemical compound FC(F)(F)C(F)(F)F WMIYKQLTONQJES-UHFFFAOYSA-N 0.000 description 1
- HCDGVLDPFQMKDK-UHFFFAOYSA-N hexafluoropropylene Chemical group FC(F)=C(F)C(F)(F)F HCDGVLDPFQMKDK-UHFFFAOYSA-N 0.000 description 1
- HTDJPCNNEPUOOQ-UHFFFAOYSA-N hexamethylcyclotrisiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1 HTDJPCNNEPUOOQ-UHFFFAOYSA-N 0.000 description 1
- XXMIOPMDWAUFGU-UHFFFAOYSA-N hexane-1,6-diol Chemical compound OCCCCCCO XXMIOPMDWAUFGU-UHFFFAOYSA-N 0.000 description 1
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- 238000003384 imaging method Methods 0.000 description 1
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- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- KKFHAJHLJHVUDM-UHFFFAOYSA-N n-vinylcarbazole Chemical compound C1=CC=C2N(C=C)C3=CC=CC=C3C2=C1 KKFHAJHLJHVUDM-UHFFFAOYSA-N 0.000 description 1
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- XNTUJOTWIMFEQS-UHFFFAOYSA-N octadecanoyl octadecaneperoxoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCCCCCCCC XNTUJOTWIMFEQS-UHFFFAOYSA-N 0.000 description 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- 229940065472 octyl acrylate Drugs 0.000 description 1
- ANISOHQJBAQUQP-UHFFFAOYSA-N octyl prop-2-enoate Chemical compound CCCCCCCCOC(=O)C=C ANISOHQJBAQUQP-UHFFFAOYSA-N 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 229960004065 perflutren Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 201000010041 presbyopia Diseases 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012719 thermal polymerization Methods 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- YODZTKMDCQEPHD-UHFFFAOYSA-N thiodiglycol Chemical compound OCCSCCO YODZTKMDCQEPHD-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
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Images
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J4/00—Adhesives based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; adhesives, based on monomers of macromolecular compounds of groups C09J183/00 - C09J183/16
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- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/08—Auxiliary lenses; Arrangements for varying focal length
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Landscapes
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Description
本出願は、本明細書に参照により組み込まれる2015年6月10日出願の米国仮出願第62/173,877号の利益を主張する。本出願はまた、本明細書に参照により組み込まれる2016年4月12日出願の米国仮出願第62/321,704号の利益も主張する。
文献の援用
なお、本願発明の実施形態として以下のものが挙げられる。
[実施形態1]
2%〜20%の量で存在するブチルアクリラートと、10%〜35%の量で存在するトリフルオロエチルメタクリラートと、50%〜80%の量で存在するフェニルエチルアクリラートとを含むポリマー材料を含む、眼内レンズ。
[実施形態2]
ポリマー材料の屈折率が1.48〜1.53である、実施形態1に記載の眼内レンズ。
[実施形態3]
ポリマー材料の屈折率が1.50〜1.53である、実施形態2に記載の眼内レンズ。
[実施形態4]
ポリマー材料が流体チャネルを画定し、眼内レンズが流体チャネル中にシリコーンオイルを更に含む、実施形態1に記載の眼内レンズ。
[実施形態5]
シリコーンオイルがポリマー材料と屈折率整合されている、実施形態4に記載の眼内レンズ。
[実施形態6]
シリコーンオイルの多分散性が1.2未満である、実施形態4に記載の眼内レンズ。
[実施形態7]
3%〜20%の量で存在するアルキルアクリラートと;
10%〜35%の量で存在するフルオロアクリラートと;
50%〜80%の量で存在するフェニルアクリラートと
を含む、眼科デバイス用のポリマー材料。
[実施形態8]
光を網膜上へ屈折させるように適合された、ポリマー材料を含む光学部と;
光学部内に配置された、多分散指数が約1.2未満であるシリコーンオイルと
を含む、調節型眼内レンズ。
[実施形態9]
シリコーンオイルの平均分子量が4500〜6500である、実施形態8に記載の調節型眼内レンズ。
[実施形態10]
粘度が2400cP以下である、実施形態8に記載の調節型眼内レンズ。
[実施形態11]
シリコーンオイルがジフェニルシロキサン単位を含む、実施形態8に記載の調節型眼内レンズ。
[実施形態12]
シリコーンオイルが、2つのジメチルシロキサン単位対1つのジフェニルシロキサン単位の比を含むシクロトリシロキサンからできている、実施形態8に記載の調節型眼内レンズ。
[実施形態13]
シリコーンオイルの屈折率が1.47〜1.53、場合により1.50〜1.53である、実施形態8に記載の調節型眼内レンズ。
[実施形態14]
調節型眼内レンズ用の接着剤であって、調節型眼内レンズの第1の物体のポリマー材料と同じである又は実質的に類似した特性を有する第1の成分を含む、接着剤。
[実施形態15]
眼内レンズの第1の物体のポリマー材料と同じである第1の成分を含む、実施形態14に記載の接着剤。
[実施形態16]
ポリマー材料中に存在するモノマーを含む第1の成分を含む、実施形態15に記載の接着剤。
[実施形態17]
反応性アクリル系希釈剤である第2の主成分を含む、実施形態14に記載の接着剤。
[実施形態18]
調節型眼内レンズの第1の物体のポリマー材料と同じではないが実質的に類似した第1の成分を含む、実施形態14に記載の接着剤。
[実施形態19]
調節型眼内レンズを製造する方法であって、
調節型眼内レンズの第1及び第2の部材を硬化させる工程と;
第1及び第2の部材の少なくとも1つと同じであるか、実質的に同じであるか、又は実質的に類似した特性を有する第1の成分を含み、反応性アクリル系希釈剤である第2の主成分を更に含む接着剤を、第1の部材と第2の部材との間に塗布する工程と
を含む、方法。
[実施形態20]
複数のモノマーを含む眼内レンズのポリマー成分を製造する方法であって、
複数のモノマーを含む、ポリマーのプレポリマーを形成する工程と;
プレポリマーを硬化してポリマー成分を形成する工程と
を含む、方法。
[実施形態21]
プレポリマーを形成する工程が、複数のモノマーとヒドロキシ部分を含むモノマーとを化合させる工程を含む、実施形態20に記載の方法。
[実施形態22]
プレポリマーから架橋性ポリマーを作る工程を更に含み、架橋性ポリマーを作る工程がヒドロキシル部分をメタクリラート部分へ変化させる工程を含む、実施形態21に記載の方法。
12 光学部
14 支持部
18 前部要素
20 後部要素
22 支持部流体チャンバー
24 光学部流体チャンバー
26 開口部
28 周縁表面
29 バットレス部分
32 流路
42 支持部の外側部分
Claims (6)
- 2%(重量%)〜20%(重量%)の量で存在するブチルアクリラートと、10%(重量%)〜35%(重量%)の量で存在するトリフルオロエチルメタクリラートと、65%(重量%)〜80%(重量%)の量で存在するフェニルエチルアクリラートとを含むポリマー材料を含む、眼内レンズ。
- ポリマー材料の屈折率が1.48〜1.53である、請求項1に記載の眼内レンズ。
- ポリマー材料の屈折率が1.50〜1.53である、請求項2に記載の眼内レンズ。
- ポリマー材料が流体チャネルを画定し、眼内レンズが流体チャネル中にシリコーンオイルを更に含む、請求項1に記載の眼内レンズ。
- シリコーンオイルがポリマー材料と屈折率整合されている、請求項4に記載の眼内レンズ。
- シリコーンオイルの多分散性が1.2未満である、請求項4に記載の眼内レンズ。
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PCT/US2016/037055 WO2016201351A1 (en) | 2015-06-10 | 2016-06-10 | Intraocular lens materials and components |
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EP3307206A4 (en) | 2019-02-20 |
EP3307206B1 (en) | 2023-09-20 |
CA2987311C (en) | 2024-01-02 |
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CA3219515A1 (en) | 2016-12-15 |
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ES2962463T3 (es) | 2024-03-19 |
AU2016275073B2 (en) | 2021-02-25 |
CN107635511A (zh) | 2018-01-26 |
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US20200246134A1 (en) | 2020-08-06 |
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