JP6837679B2 - 硫酸デキストランの新しい使用 - Google Patents
硫酸デキストランの新しい使用 Download PDFInfo
- Publication number
- JP6837679B2 JP6837679B2 JP2018503496A JP2018503496A JP6837679B2 JP 6837679 B2 JP6837679 B2 JP 6837679B2 JP 2018503496 A JP2018503496 A JP 2018503496A JP 2018503496 A JP2018503496 A JP 2018503496A JP 6837679 B2 JP6837679 B2 JP 6837679B2
- Authority
- JP
- Japan
- Prior art keywords
- dextran sulfate
- pharmaceutically acceptable
- acceptable salt
- subject
- fibrosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
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- 230000037396 body weight Effects 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 8
- 239000011593 sulfur Substances 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/02—Dextran; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1551050A SE539575C2 (en) | 2015-07-30 | 2015-07-30 | Dextran sulfate for use in treating, inhibiting or preventing cardiac fibrosis |
| SE1551050-6 | 2015-07-30 | ||
| PCT/SE2016/050720 WO2017018922A1 (en) | 2015-07-30 | 2016-07-15 | New use of dextran sulfate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521086A JP2018521086A (ja) | 2018-08-02 |
| JP2018521086A5 JP2018521086A5 (enExample) | 2018-09-13 |
| JP6837679B2 true JP6837679B2 (ja) | 2021-03-03 |
Family
ID=57884849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503496A Active JP6837679B2 (ja) | 2015-07-30 | 2016-07-15 | 硫酸デキストランの新しい使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10478451B2 (enExample) |
| EP (1) | EP3328395B1 (enExample) |
| JP (1) | JP6837679B2 (enExample) |
| CN (2) | CN114712385A (enExample) |
| BR (1) | BR112018001942A2 (enExample) |
| DK (1) | DK3328395T3 (enExample) |
| EA (1) | EA034313B1 (enExample) |
| ES (1) | ES2882115T3 (enExample) |
| HK (1) | HK1246640A1 (enExample) |
| SE (1) | SE539575C2 (enExample) |
| WO (1) | WO2017018922A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018212708A1 (en) * | 2017-05-17 | 2018-11-22 | Tx Medic Ab | Treatment of glaucoma |
| EP3532072B1 (en) * | 2017-05-17 | 2020-01-01 | TX Medic AB | Treatment of glaucoma |
| JP2020533281A (ja) * | 2017-09-08 | 2020-11-19 | ティーエックス メディック エービー | デキストラン硫酸の新規使用 |
| CN111867647B (zh) * | 2018-03-09 | 2023-01-13 | 卡梅达股份公司 | 用于固定生物物质的方法的改进 |
| SE543275C2 (en) * | 2019-03-07 | 2020-11-10 | Tx Medic Ab | Treatment efficiency evaluation |
| SE544447C2 (en) * | 2020-09-29 | 2022-05-31 | Tx Medic Ab | Treatment of fatty liver diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605938A (en) * | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
| JP2000507204A (ja) | 1995-12-18 | 2000-06-13 | ステイヒテイング・サンキン・ブロードボールジーニング | Ｃ１―インヒビターの補体及び血液凝固阻害特性の強化 |
| US20040224922A1 (en) | 1999-08-26 | 2004-11-11 | Malcolm King | Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto |
| SE525461C3 (sv) * | 2002-11-28 | 2005-03-23 | Prophymed Ab | Ny användning av dextransulfat |
| WO2007028053A2 (en) * | 2005-09-02 | 2007-03-08 | X-Cell Medical Incorporated | Methods of treating and preventing cardiac disorders |
| WO2007075388A2 (en) * | 2005-12-15 | 2007-07-05 | X-Cell Medical Incorporated | Methods of locally treating and preventing cardiac disorders |
| WO2008134430A1 (en) * | 2007-04-24 | 2008-11-06 | Novelmed Therapeutics Inc. | Methods and compositions of inhibiting complement and cellular activation with dextran sulfate |
| WO2011091167A2 (en) * | 2010-01-22 | 2011-07-28 | The General Hospital Corporation | Lysophosphatidic acid receptor targeting for scleroderma and other fibrotic diseases |
| EP2768522B1 (en) * | 2011-10-18 | 2016-07-27 | CSL Behring GmbH | Use of sulfated glycosaminoglycans for improving the bioavailability of factor viii |
| CN102973593A (zh) * | 2012-11-26 | 2013-03-20 | 合肥博太医药生物技术发展有限公司 | 硫酸葡聚糖在制备治疗肝纤维化药物中的应用 |
| WO2015190989A1 (en) | 2014-06-12 | 2015-12-17 | Tx Medic Ab | The use of dextran sulfate having an average molecular weight below 10000 da for inducing angiogenisis in a subject |
| HRP20190051T1 (hr) * | 2014-06-12 | 2019-03-08 | Tx Medic Ab | Uporaba dekstran sulfata koji ima prosječnu molekularnu masu ispod 10000 da za induciranje angiogeneze kod subjekta |
-
2015
- 2015-07-30 SE SE1551050A patent/SE539575C2/en unknown
-
2016
- 2016-07-15 EP EP16830923.5A patent/EP3328395B1/en active Active
- 2016-07-15 HK HK18106000.5A patent/HK1246640A1/zh unknown
- 2016-07-15 JP JP2018503496A patent/JP6837679B2/ja active Active
- 2016-07-15 DK DK16830923.5T patent/DK3328395T3/da active
- 2016-07-15 US US15/748,519 patent/US10478451B2/en active Active
- 2016-07-15 EA EA201890212A patent/EA034313B1/ru not_active IP Right Cessation
- 2016-07-15 ES ES16830923T patent/ES2882115T3/es active Active
- 2016-07-15 BR BR112018001942A patent/BR112018001942A2/pt not_active Application Discontinuation
- 2016-07-15 CN CN202210555037.5A patent/CN114712385A/zh active Pending
- 2016-07-15 CN CN201680044788.3A patent/CN107921055A/zh active Pending
- 2016-07-15 WO PCT/SE2016/050720 patent/WO2017018922A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN107921055A (zh) | 2018-04-17 |
| WO2017018922A1 (en) | 2017-02-02 |
| EA034313B1 (ru) | 2020-01-28 |
| SE1551050A1 (en) | 2017-01-31 |
| EP3328395A1 (en) | 2018-06-06 |
| EP3328395A4 (en) | 2018-06-20 |
| JP2018521086A (ja) | 2018-08-02 |
| EP3328395B1 (en) | 2021-06-09 |
| CN114712385A (zh) | 2022-07-08 |
| SE539575C2 (en) | 2017-10-17 |
| DK3328395T3 (da) | 2021-08-09 |
| US10478451B2 (en) | 2019-11-19 |
| BR112018001942A2 (pt) | 2018-09-18 |
| EA201890212A1 (ru) | 2018-06-29 |
| ES2882115T3 (es) | 2021-12-01 |
| HK1246640A1 (zh) | 2018-09-14 |
| US20180221403A1 (en) | 2018-08-09 |
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