EA034313B1 - Применение сульфата декстрана - Google Patents
Применение сульфата декстрана Download PDFInfo
- Publication number
- EA034313B1 EA034313B1 EA201890212A EA201890212A EA034313B1 EA 034313 B1 EA034313 B1 EA 034313B1 EA 201890212 A EA201890212 A EA 201890212A EA 201890212 A EA201890212 A EA 201890212A EA 034313 B1 EA034313 B1 EA 034313B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dextran sulfate
- pharmaceutically acceptable
- acceptable salt
- fibrosis
- subject
- Prior art date
Links
- 229960000633 dextran sulfate Drugs 0.000 title claims abstract description 123
- 150000003839 salts Chemical class 0.000 claims abstract description 58
- 238000000034 method Methods 0.000 claims abstract description 38
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 14
- 238000007920 subcutaneous administration Methods 0.000 claims abstract description 9
- 239000007864 aqueous solution Substances 0.000 claims abstract description 8
- 238000002347 injection Methods 0.000 claims abstract description 8
- 239000007924 injection Substances 0.000 claims abstract description 8
- 238000001990 intravenous administration Methods 0.000 claims abstract description 5
- 239000003125 aqueous solvent Substances 0.000 claims abstract description 4
- 206010016654 Fibrosis Diseases 0.000 claims description 61
- 230000004761 fibrosis Effects 0.000 claims description 61
- 206010028594 Myocardial fibrosis Diseases 0.000 claims description 22
- 208000010125 myocardial infarction Diseases 0.000 claims description 22
- 210000002216 heart Anatomy 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 14
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 239000011593 sulfur Substances 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 206010061216 Infarction Diseases 0.000 claims description 7
- 238000005481 NMR spectroscopy Methods 0.000 claims description 7
- 230000037396 body weight Effects 0.000 claims description 7
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 7
- 230000007574 infarction Effects 0.000 claims description 7
- 208000035475 disorder Diseases 0.000 claims description 6
- 230000005764 inhibitory process Effects 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
- 206010038748 Restrictive cardiomyopathy Diseases 0.000 claims description 3
- 230000001746 atrial effect Effects 0.000 claims description 3
- 201000010048 endomyocardial fibrosis Diseases 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 208000031225 myocardial ischemia Diseases 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 230000009787 cardiac fibrosis Effects 0.000 abstract 1
- 238000007910 systemic administration Methods 0.000 description 20
- 241001465754 Metazoa Species 0.000 description 13
- 210000001519 tissue Anatomy 0.000 description 11
- 230000009931 harmful effect Effects 0.000 description 10
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- 230000001575 pathological effect Effects 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 210000002808 connective tissue Anatomy 0.000 description 5
- 230000000254 damaging effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
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- 239000005017 polysaccharide Substances 0.000 description 4
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- 206010019280 Heart failures Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000000149 argon plasma sintering Methods 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
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- 239000008363 phosphate buffer Substances 0.000 description 2
- DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
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- RQPKNXVVIBYOBX-KDBLBPRBSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid;(2s)-2-(dihydroxyamino)-3-phenylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.ON(O)[C@H](C(O)=O)CC1=CC=CC=C1 RQPKNXVVIBYOBX-KDBLBPRBSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 108060003393 Granulin Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010072877 Intestinal fibrosis Diseases 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
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- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 208000009982 Ventricular Dysfunction Diseases 0.000 description 1
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- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 229960002303 citric acid monohydrate Drugs 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229960002086 dextran Drugs 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
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- 230000005182 global health Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
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- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000000185 intracerebroventricular administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
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- 210000004165 myocardium Anatomy 0.000 description 1
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- 210000003516 pericardium Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
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- 230000002829 reductive effect Effects 0.000 description 1
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- 230000004044 response Effects 0.000 description 1
- 230000008458 response to injury Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
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- 238000007492 two-way ANOVA Methods 0.000 description 1
- 238000007473 univariate analysis Methods 0.000 description 1
- 230000006815 ventricular dysfunction Effects 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/02—Dextran; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1551050A SE539575C2 (en) | 2015-07-30 | 2015-07-30 | Dextran sulfate for use in treating, inhibiting or preventing cardiac fibrosis |
| PCT/SE2016/050720 WO2017018922A1 (en) | 2015-07-30 | 2016-07-15 | New use of dextran sulfate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201890212A1 EA201890212A1 (ru) | 2018-06-29 |
| EA034313B1 true EA034313B1 (ru) | 2020-01-28 |
Family
ID=57884849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890212A EA034313B1 (ru) | 2015-07-30 | 2016-07-15 | Применение сульфата декстрана |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10478451B2 (enExample) |
| EP (1) | EP3328395B1 (enExample) |
| JP (1) | JP6837679B2 (enExample) |
| CN (2) | CN114712385A (enExample) |
| BR (1) | BR112018001942A2 (enExample) |
| DK (1) | DK3328395T3 (enExample) |
| EA (1) | EA034313B1 (enExample) |
| ES (1) | ES2882115T3 (enExample) |
| HK (1) | HK1246640A1 (enExample) |
| SE (1) | SE539575C2 (enExample) |
| WO (1) | WO2017018922A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2777836T3 (es) * | 2017-05-17 | 2020-08-06 | Tx Medic Ab | Tratamiento del glaucoma |
| WO2018212708A1 (en) * | 2017-05-17 | 2018-11-22 | Tx Medic Ab | Treatment of glaucoma |
| IL272935B2 (en) * | 2017-09-08 | 2025-04-01 | Tx Medic Ab | New use of dextran sulfate |
| CA3093027A1 (en) * | 2018-03-09 | 2019-09-12 | Carmeda Ab | Improvements to processes for immobilising biological entities |
| SE543275C2 (en) * | 2019-03-07 | 2020-11-10 | Tx Medic Ab | Treatment efficiency evaluation |
| SE544447C2 (en) * | 2020-09-29 | 2022-05-31 | Tx Medic Ab | Treatment of fatty liver diseases |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008134430A1 (en) * | 2007-04-24 | 2008-11-06 | Novelmed Therapeutics Inc. | Methods and compositions of inhibiting complement and cellular activation with dextran sulfate |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605938A (en) * | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
| EP0868191A1 (en) | 1995-12-18 | 1998-10-07 | Stichting Sanquin Bloedvoorziening | Potentiation of complement and coagulation inhibitory properties of c1-inhibitor. |
| US20040224922A1 (en) | 1999-08-26 | 2004-11-11 | Malcolm King | Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto |
| SE525461C3 (sv) * | 2002-11-28 | 2005-03-23 | Prophymed Ab | Ny användning av dextransulfat |
| WO2007028053A2 (en) * | 2005-09-02 | 2007-03-08 | X-Cell Medical Incorporated | Methods of treating and preventing cardiac disorders |
| WO2007075388A2 (en) * | 2005-12-15 | 2007-07-05 | X-Cell Medical Incorporated | Methods of locally treating and preventing cardiac disorders |
| WO2011091167A2 (en) * | 2010-01-22 | 2011-07-28 | The General Hospital Corporation | Lysophosphatidic acid receptor targeting for scleroderma and other fibrotic diseases |
| US9393289B2 (en) * | 2011-10-18 | 2016-07-19 | Csl Behring Gmbh | Use of sulfated glycosaminoglycans for improving the bioavailability of factor VIII |
| CN102973593A (zh) * | 2012-11-26 | 2013-03-20 | 合肥博太医药生物技术发展有限公司 | 硫酸葡聚糖在制备治疗肝纤维化药物中的应用 |
| WO2015190989A1 (en) * | 2014-06-12 | 2015-12-17 | Tx Medic Ab | The use of dextran sulfate having an average molecular weight below 10000 da for inducing angiogenisis in a subject |
| PT3154551T (pt) * | 2014-06-12 | 2019-01-18 | Tx Medic Ab | A utilização de sulfato de dextrano tendo uma massa molecular média inferior a 10000 da para induzir angiogénese num sujeito |
-
2015
- 2015-07-30 SE SE1551050A patent/SE539575C2/en unknown
-
2016
- 2016-07-15 BR BR112018001942A patent/BR112018001942A2/pt not_active Application Discontinuation
- 2016-07-15 WO PCT/SE2016/050720 patent/WO2017018922A1/en not_active Ceased
- 2016-07-15 ES ES16830923T patent/ES2882115T3/es active Active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008134430A1 (en) * | 2007-04-24 | 2008-11-06 | Novelmed Therapeutics Inc. | Methods and compositions of inhibiting complement and cellular activation with dextran sulfate |
Non-Patent Citations (5)
| Title |
|---|
| BANZ, Y. et al., "Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injury", Eur Heart J, 2005, vol. 26, p. 2334-2343; whole document; page 2335, column 1, paragraph [0003]; page 2335, column 1, paragraph [0005]; page 2339, column 2, paragraph [0001]; page 2341, column 1, paragraph [0001] * |
| Dextran sulfate product information [online], Sigma Aldrich [retrieved on 19-09-2016], Retrieved from the Internet: <URL:https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Product_Information_Sheet/d8906pis.pdf>; whole document * |
| Dextran sulfate product specification [online], Sigma Aldrich [retrieved on 19-09-2016], Retrieved from the Internet: <URL:http://www.sigmaaldrich.com/Graphics/COfAInfo/SigmaSAPQM/SPEC/D7/D7037/D7037-BULK_SIAL_.pdf>; whole document * |
| KRENNING, G. et al., "The Origin of Fibroblasts and Mechanism of Cardiac Fibrosis", J Cell Physio, 2010, vol. 225, p. 631-637; page 631, column 1, paragraph [0002] * |
| MERCER, P.F. et al., "Coagulation and coagulation signalling in fibrosis", Biochim Biophys Acta, 2013, p. 1018-1027; whole document; page 1022, paragraph [0044] * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6837679B2 (ja) | 2021-03-03 |
| JP2018521086A (ja) | 2018-08-02 |
| ES2882115T3 (es) | 2021-12-01 |
| EP3328395A4 (en) | 2018-06-20 |
| BR112018001942A2 (pt) | 2018-09-18 |
| US10478451B2 (en) | 2019-11-19 |
| CN107921055A (zh) | 2018-04-17 |
| US20180221403A1 (en) | 2018-08-09 |
| HK1246640A1 (zh) | 2018-09-14 |
| EP3328395A1 (en) | 2018-06-06 |
| CN114712385A (zh) | 2022-07-08 |
| SE1551050A1 (en) | 2017-01-31 |
| EA201890212A1 (ru) | 2018-06-29 |
| EP3328395B1 (en) | 2021-06-09 |
| WO2017018922A1 (en) | 2017-02-02 |
| DK3328395T3 (da) | 2021-08-09 |
| SE539575C2 (en) | 2017-10-17 |
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