JP6829928B2 - 二相性単鎖インスリン類似体 - Google Patents

二相性単鎖インスリン類似体 Download PDF

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Publication number
JP6829928B2
JP6829928B2 JP2017518189A JP2017518189A JP6829928B2 JP 6829928 B2 JP6829928 B2 JP 6829928B2 JP 2017518189 A JP2017518189 A JP 2017518189A JP 2017518189 A JP2017518189 A JP 2017518189A JP 6829928 B2 JP6829928 B2 JP 6829928B2
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insulin
chain insulin
chain
amino acid
region
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Japanese (ja)
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JP2017536337A5 (https=
JP2017536337A (ja
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ワイス、マイケル
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Case Western Reserve University
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Case Western Reserve University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2017518189A 2014-10-06 2015-10-06 二相性単鎖インスリン類似体 Active JP6829928B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462060167P 2014-10-06 2014-10-06
US62/060,167 2014-10-06
PCT/US2015/054263 WO2016057529A2 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Publications (3)

Publication Number Publication Date
JP2017536337A JP2017536337A (ja) 2017-12-07
JP2017536337A5 JP2017536337A5 (https=) 2018-11-08
JP6829928B2 true JP6829928B2 (ja) 2021-02-17

Family

ID=55653938

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017518189A Active JP6829928B2 (ja) 2014-10-06 2015-10-06 二相性単鎖インスリン類似体

Country Status (10)

Country Link
US (2) US10392429B2 (https=)
EP (1) EP3204410B1 (https=)
JP (1) JP6829928B2 (https=)
KR (1) KR102569743B1 (https=)
CN (1) CN107108716A (https=)
AU (1) AU2015328222B9 (https=)
BR (1) BR112017004544A2 (https=)
CA (1) CA2961037A1 (https=)
IL (1) IL251503A0 (https=)
WO (1) WO2016057529A2 (https=)

Families Citing this family (15)

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WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
JP7203415B2 (ja) * 2015-12-23 2023-01-13 ケース ウェスタン リザーブ ユニバーシティ ポリマー溶融物内の超安定型インスリン類似体のカプセル化
MY200047A (en) * 2016-11-21 2023-12-06 Univ Case Western Reserve Rapid-acting insulin analogues of enhanced stability
KR20210029210A (ko) * 2018-06-29 2021-03-15 악스톤 바이오사이언시스 코퍼레이션 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법
WO2020061554A1 (en) * 2018-09-21 2020-03-26 Case Western Reserve University Site 2 single-chain insulin analogues
US12077568B2 (en) 2018-10-01 2024-09-03 University Of Houston System Engineered active single-polypeptide chain insulin analogs
EP3883957A4 (en) * 2018-11-19 2022-08-17 Case Western Reserve University SINGLE-CHAIN INSULIN ANALOGS WITH POLYALANINE C-DOMAIN SUBSEGMENTS
US20220235111A1 (en) * 2019-05-17 2022-07-28 Case Western Reserve University Variant Single-Chain Insulin Analogues
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
AU2020324961A1 (en) * 2019-08-02 2022-03-24 Case Western Reserve University Premixed ultra-stable single-chain insulin analogue formulations
EP4114442A4 (en) * 2020-03-02 2024-10-02 CS Pharmaceuticals, LLC COMPOSITIONS WITH FAST-ACTING INSULIN ANALOGUES
EP4255469A4 (en) * 2020-12-07 2025-01-22 Case Western Reserve University ACYLATED SINGLE-CHAIN INSULIN ANALOGUES
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou
EP4405384A1 (en) 2021-09-20 2024-07-31 Kyon Biotech AG Arginase-insulin fusion protein

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US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
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Also Published As

Publication number Publication date
KR20170064533A (ko) 2017-06-09
CA2961037A1 (en) 2016-04-14
EP3204410B1 (en) 2021-01-20
AU2015328222B9 (en) 2020-12-24
US20180265560A1 (en) 2018-09-20
AU2015328222A1 (en) 2017-03-16
US20190375814A1 (en) 2019-12-12
EP3204410A2 (en) 2017-08-16
BR112017004544A2 (pt) 2018-01-23
US10392429B2 (en) 2019-08-27
AU2015328222B2 (en) 2020-08-20
EP3204410A4 (en) 2018-03-07
IL251503A0 (en) 2017-05-29
US11142560B2 (en) 2021-10-12
KR102569743B1 (ko) 2023-08-23
WO2016057529A3 (en) 2016-11-03
CN107108716A (zh) 2017-08-29
WO2016057529A2 (en) 2016-04-14
JP2017536337A (ja) 2017-12-07

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