CA2961037A1 - Biphasic single-chain insulin analogues - Google Patents

Biphasic single-chain insulin analogues Download PDF

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Publication number
CA2961037A1
CA2961037A1 CA2961037A CA2961037A CA2961037A1 CA 2961037 A1 CA2961037 A1 CA 2961037A1 CA 2961037 A CA2961037 A CA 2961037A CA 2961037 A CA2961037 A CA 2961037A CA 2961037 A1 CA2961037 A1 CA 2961037A1
Authority
CA
Canada
Prior art keywords
insulin
chain insulin
chain
seq
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2961037A
Other languages
English (en)
French (fr)
Inventor
Michael Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of CA2961037A1 publication Critical patent/CA2961037A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA2961037A 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues Pending CA2961037A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462060167P 2014-10-06 2014-10-06
US62/060,167 2014-10-06
PCT/US2015/054263 WO2016057529A2 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Publications (1)

Publication Number Publication Date
CA2961037A1 true CA2961037A1 (en) 2016-04-14

Family

ID=55653938

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2961037A Pending CA2961037A1 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Country Status (10)

Country Link
US (2) US10392429B2 (https=)
EP (1) EP3204410B1 (https=)
JP (1) JP6829928B2 (https=)
KR (1) KR102569743B1 (https=)
CN (1) CN107108716A (https=)
AU (1) AU2015328222B9 (https=)
BR (1) BR112017004544A2 (https=)
CA (1) CA2961037A1 (https=)
IL (1) IL251503A0 (https=)
WO (1) WO2016057529A2 (https=)

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AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
JP7203415B2 (ja) * 2015-12-23 2023-01-13 ケース ウェスタン リザーブ ユニバーシティ ポリマー溶融物内の超安定型インスリン類似体のカプセル化
MY200047A (en) * 2016-11-21 2023-12-06 Univ Case Western Reserve Rapid-acting insulin analogues of enhanced stability
KR20210029210A (ko) * 2018-06-29 2021-03-15 악스톤 바이오사이언시스 코퍼레이션 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법
WO2020061554A1 (en) * 2018-09-21 2020-03-26 Case Western Reserve University Site 2 single-chain insulin analogues
US12077568B2 (en) 2018-10-01 2024-09-03 University Of Houston System Engineered active single-polypeptide chain insulin analogs
EP3883957A4 (en) * 2018-11-19 2022-08-17 Case Western Reserve University SINGLE-CHAIN INSULIN ANALOGS WITH POLYALANINE C-DOMAIN SUBSEGMENTS
US20220235111A1 (en) * 2019-05-17 2022-07-28 Case Western Reserve University Variant Single-Chain Insulin Analogues
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
AU2020324961A1 (en) * 2019-08-02 2022-03-24 Case Western Reserve University Premixed ultra-stable single-chain insulin analogue formulations
EP4114442A4 (en) * 2020-03-02 2024-10-02 CS Pharmaceuticals, LLC COMPOSITIONS WITH FAST-ACTING INSULIN ANALOGUES
EP4255469A4 (en) * 2020-12-07 2025-01-22 Case Western Reserve University ACYLATED SINGLE-CHAIN INSULIN ANALOGUES
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou
EP4405384A1 (en) 2021-09-20 2024-07-31 Kyon Biotech AG Arginase-insulin fusion protein

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US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
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WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
EA201200717A1 (ru) 2009-12-11 2013-03-29 Кейз Вестерн Ризев Юнивесити Аналоги инсулина, содержащие хлорированные аминокислоты
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Also Published As

Publication number Publication date
JP6829928B2 (ja) 2021-02-17
KR20170064533A (ko) 2017-06-09
EP3204410B1 (en) 2021-01-20
AU2015328222B9 (en) 2020-12-24
US20180265560A1 (en) 2018-09-20
AU2015328222A1 (en) 2017-03-16
US20190375814A1 (en) 2019-12-12
EP3204410A2 (en) 2017-08-16
BR112017004544A2 (pt) 2018-01-23
US10392429B2 (en) 2019-08-27
AU2015328222B2 (en) 2020-08-20
EP3204410A4 (en) 2018-03-07
IL251503A0 (en) 2017-05-29
US11142560B2 (en) 2021-10-12
KR102569743B1 (ko) 2023-08-23
WO2016057529A3 (en) 2016-11-03
CN107108716A (zh) 2017-08-29
WO2016057529A2 (en) 2016-04-14
JP2017536337A (ja) 2017-12-07

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