AU2015328222B9 - Biphasic single-chain insulin analogues - Google Patents

Biphasic single-chain insulin analogues Download PDF

Info

Publication number
AU2015328222B9
AU2015328222B9 AU2015328222A AU2015328222A AU2015328222B9 AU 2015328222 B9 AU2015328222 B9 AU 2015328222B9 AU 2015328222 A AU2015328222 A AU 2015328222A AU 2015328222 A AU2015328222 A AU 2015328222A AU 2015328222 B9 AU2015328222 B9 AU 2015328222B9
Authority
AU
Australia
Prior art keywords
insulin
domain
chain insulin
chain
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015328222A
Other languages
English (en)
Other versions
AU2015328222B2 (en
AU2015328222A1 (en
Inventor
Michael Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of AU2015328222A1 publication Critical patent/AU2015328222A1/en
Application granted granted Critical
Publication of AU2015328222B2 publication Critical patent/AU2015328222B2/en
Publication of AU2015328222B9 publication Critical patent/AU2015328222B9/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AU2015328222A 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues Active AU2015328222B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462060167P 2014-10-06 2014-10-06
US62/060,167 2014-10-06
PCT/US2015/054263 WO2016057529A2 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Publications (3)

Publication Number Publication Date
AU2015328222A1 AU2015328222A1 (en) 2017-03-16
AU2015328222B2 AU2015328222B2 (en) 2020-08-20
AU2015328222B9 true AU2015328222B9 (en) 2020-12-24

Family

ID=55653938

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015328222A Active AU2015328222B9 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Country Status (10)

Country Link
US (2) US10392429B2 (https=)
EP (1) EP3204410B1 (https=)
JP (1) JP6829928B2 (https=)
KR (1) KR102569743B1 (https=)
CN (1) CN107108716A (https=)
AU (1) AU2015328222B9 (https=)
BR (1) BR112017004544A2 (https=)
CA (1) CA2961037A1 (https=)
IL (1) IL251503A0 (https=)
WO (1) WO2016057529A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102351111B1 (ko) 2014-01-13 2022-01-14 써멀린 다이어비티즈, 엘엘씨 초속효성 인슐린 제형 및 약제학적 전달 시스템
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
EP3393498A4 (en) * 2015-12-23 2019-08-07 Case Western Reserve University SECULATION OF ULTRASTABILEN INSULIN ANALOGUE WITH POLYMER MELTS
CA3294636A1 (en) * 2016-11-21 2026-02-10 Case Western Reserve University Rapid-acting insulin analogues of enhanced stability
KR20210029210A (ko) * 2018-06-29 2021-03-15 악스톤 바이오사이언시스 코퍼레이션 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법
US20210371489A1 (en) * 2018-09-21 2021-12-02 Case Western Reserve University Site 2 single-chain insulin analogues
US12077568B2 (en) 2018-10-01 2024-09-03 University Of Houston System Engineered active single-polypeptide chain insulin analogs
CN113330025A (zh) * 2018-11-19 2021-08-31 卡斯西部储备大学 具有聚丙氨酸c结构域子区段的单链胰岛素类似物
CA3139946A1 (en) * 2019-05-17 2020-11-26 Case Western Reserve University Variant single-chain insulin analogues
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
CA3149925A1 (en) * 2019-08-02 2021-02-11 Case Western Reserve University Premixed ultra-stable single-chain insulin analogue formulations
IL296090A (en) * 2020-03-02 2022-11-01 Thermalin Inc Compositions containing rapid-acting insulin analogues
EP4255469A4 (en) * 2020-12-07 2025-01-22 Case Western Reserve University ACYLATED SINGLE-CHAIN INSULIN ANALOGUES
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou
CN118201954A (zh) 2021-09-20 2024-06-14 克云生物科技股份公司 精氨酸酶-胰岛素融合蛋白

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085472A1 (en) * 2003-03-27 2004-10-07 Novo Nordisk A/S Method for making human insulin precursors and human insulin
WO2014071405A2 (en) * 2012-11-05 2014-05-08 Case Western Reserve University Long-acting single-chain insulin analogues

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
JPH03506023A (ja) 1988-07-20 1991-12-26 ノボ　ノルデイスク　アクツイエセルスカプ ポリペプチド
US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
DE3936876A1 (de) 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK158390D0 (da) 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
US5422339A (en) 1991-03-19 1995-06-06 Joslin Diabetes Center, Inc. Peptides having insulin autoantibody but not insulin receptor binding capacity
NZ245170A (en) 1991-11-26 1994-07-26 Lilly Co Eli Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US20030104981A1 (en) 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
DE19652713C2 (de) 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
JP2001521006A (ja) 1997-10-24 2001-11-06 イーライ・リリー・アンド・カンパニー 不溶性インシュリン組成物
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US7449443B2 (en) 2000-03-23 2008-11-11 California Institute Of Technology Method for stabilization of proteins using non-natural amino acids
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
KR100449454B1 (ko) 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
AU2002346491A1 (en) 2001-12-19 2003-07-09 Eli Lilly And Company Crystalline compositions for controlling blood glucose
CZ2004710A3 (cs) 2001-12-20 2005-02-16 Eli Lilly And Company Inzulínová sloučenina s protrahovaným účinkem
WO2003080666A2 (en) 2002-03-26 2003-10-02 Council Of Scientific And Industrial Research An adipocyte insulin and a method of treating diabetes
WO2003093299A2 (en) 2002-05-06 2003-11-13 Thomas Jefferson University Insulin-associated peptides with effects on cerebral health
EP1620465A2 (en) 2003-04-29 2006-02-01 Eli Lilly And Company Insulin analogs having protracted time action
PL1633876T3 (pl) 2003-06-17 2009-01-30 Sembiosys Genetics Inc Sposoby wytwarzania insuliny w roślinach
EP1692168B1 (en) * 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
CN102660614A (zh) 2005-08-16 2012-09-12 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
WO2007081824A2 (en) 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
US20090069216A1 (en) 2006-02-21 2009-03-12 Novo Nordisk A/S Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
US8192857B2 (en) * 2006-03-04 2012-06-05 Enerdel, Inc. Battery assembly and method of forming the same
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US7790677B2 (en) 2006-12-13 2010-09-07 Elona Biotechnologies Insulin production methods and pro-insulin constructs
MY152979A (en) 2008-01-09 2014-12-15 Sanofi Aventis Deutschland Novel insulin derivatives having an extremely delayed time-action profile
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
EP2296692A4 (en) * 2008-04-22 2012-06-06 Univ Case Western Reserve ISOFORM-SPECIFIC INSULIN ANALOG
WO2009133099A2 (en) 2008-04-28 2009-11-05 Novo Nordisk A/S Insulin precursors for diabetes treatment
MX2011001181A (es) 2008-07-31 2011-04-05 Univ Case Western Reserve Insulina estabilizada con halogeno.
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
AU2010327949A1 (en) 2009-12-11 2012-06-28 Case Western Reserve University Insulin analogues with chlorinated amino acids
PH12012501557A1 (en) 2010-02-22 2012-10-22 Univ Case Western Reserve Long-acting insulin analogue preparations in soluble and crystalline form
JP5969469B2 (ja) 2010-06-16 2016-08-17 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085472A1 (en) * 2003-03-27 2004-10-07 Novo Nordisk A/S Method for making human insulin precursors and human insulin
WO2014071405A2 (en) * 2012-11-05 2014-05-08 Case Western Reserve University Long-acting single-chain insulin analogues

Also Published As

Publication number Publication date
CA2961037A1 (en) 2016-04-14
JP2017536337A (ja) 2017-12-07
US11142560B2 (en) 2021-10-12
IL251503A0 (en) 2017-05-29
US10392429B2 (en) 2019-08-27
JP6829928B2 (ja) 2021-02-17
EP3204410A4 (en) 2018-03-07
WO2016057529A2 (en) 2016-04-14
KR102569743B1 (ko) 2023-08-23
US20180265560A1 (en) 2018-09-20
EP3204410A2 (en) 2017-08-16
AU2015328222B2 (en) 2020-08-20
KR20170064533A (ko) 2017-06-09
US20190375814A1 (en) 2019-12-12
BR112017004544A2 (pt) 2018-01-23
WO2016057529A3 (en) 2016-11-03
EP3204410B1 (en) 2021-01-20
AU2015328222A1 (en) 2017-03-16
CN107108716A (zh) 2017-08-29

Similar Documents

Publication Publication Date Title
US11142560B2 (en) Biphasic single-chain insulin analogues
US11174303B2 (en) Single-chain insulin analogues stabilized by a fourth disulfide bridge
AU2013337250B2 (en) Long-acting single-chain insulin analogues
US20220002373A1 (en) Single-chain insulin analogues with poly-alanine c-domain sub-segments
AU2013337250A1 (en) Long-acting single-chain insulin analogues
EP2948166B1 (en) N-terminal truncated insulin analogues
CA2964918A1 (en) Halogenated insulin analogues of enhanced biological potency
US20220280614A1 (en) Premixed Ultra-Stable Single-Chain Insulin Analogue Formulations
HK1238651A1 (en) Biphasic single-chain insulin analogues
HK40045373A (en) Long-acting single-chain insulin analogues

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
SREP Specification republished