JP2017536337A5 - - Google Patents
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- Publication number
- JP2017536337A5 JP2017536337A5 JP2017518189A JP2017518189A JP2017536337A5 JP 2017536337 A5 JP2017536337 A5 JP 2017536337A5 JP 2017518189 A JP2017518189 A JP 2017518189A JP 2017518189 A JP2017518189 A JP 2017518189A JP 2017536337 A5 JP2017536337 A5 JP 2017536337A5
- Authority
- JP
- Japan
- Prior art keywords
- chain insulin
- amino acid
- insulin
- region
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462060167P | 2014-10-06 | 2014-10-06 | |
| US62/060,167 | 2014-10-06 | ||
| PCT/US2015/054263 WO2016057529A2 (en) | 2014-10-06 | 2015-10-06 | Biphasic single-chain insulin analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536337A JP2017536337A (ja) | 2017-12-07 |
| JP2017536337A5 true JP2017536337A5 (https=) | 2018-11-08 |
| JP6829928B2 JP6829928B2 (ja) | 2021-02-17 |
Family
ID=55653938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518189A Active JP6829928B2 (ja) | 2014-10-06 | 2015-10-06 | 二相性単鎖インスリン類似体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10392429B2 (https=) |
| EP (1) | EP3204410B1 (https=) |
| JP (1) | JP6829928B2 (https=) |
| KR (1) | KR102569743B1 (https=) |
| CN (1) | CN107108716A (https=) |
| AU (1) | AU2015328222B9 (https=) |
| BR (1) | BR112017004544A2 (https=) |
| CA (1) | CA2961037A1 (https=) |
| IL (1) | IL251503A0 (https=) |
| WO (1) | WO2016057529A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015106269A2 (en) | 2014-01-13 | 2015-07-16 | Thermalin Diabetes, Llc | Rapid action insulin formulations and pharmaceutical delivery systems |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| JP7203415B2 (ja) * | 2015-12-23 | 2023-01-13 | ケース ウェスタン リザーブ ユニバーシティ | ポリマー溶融物内の超安定型インスリン類似体のカプセル化 |
| MY200047A (en) * | 2016-11-21 | 2023-12-06 | Univ Case Western Reserve | Rapid-acting insulin analogues of enhanced stability |
| KR20210029210A (ko) * | 2018-06-29 | 2021-03-15 | 악스톤 바이오사이언시스 코퍼레이션 | 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법 |
| WO2020061554A1 (en) * | 2018-09-21 | 2020-03-26 | Case Western Reserve University | Site 2 single-chain insulin analogues |
| US12077568B2 (en) | 2018-10-01 | 2024-09-03 | University Of Houston System | Engineered active single-polypeptide chain insulin analogs |
| EP3883957A4 (en) * | 2018-11-19 | 2022-08-17 | Case Western Reserve University | SINGLE-CHAIN INSULIN ANALOGS WITH POLYALANINE C-DOMAIN SUBSEGMENTS |
| US20220235111A1 (en) * | 2019-05-17 | 2022-07-28 | Case Western Reserve University | Variant Single-Chain Insulin Analogues |
| TWI844709B (zh) | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| AU2020324961A1 (en) * | 2019-08-02 | 2022-03-24 | Case Western Reserve University | Premixed ultra-stable single-chain insulin analogue formulations |
| EP4114442A4 (en) * | 2020-03-02 | 2024-10-02 | CS Pharmaceuticals, LLC | COMPOSITIONS WITH FAST-ACTING INSULIN ANALOGUES |
| EP4255469A4 (en) * | 2020-12-07 | 2025-01-22 | Case Western Reserve University | ACYLATED SINGLE-CHAIN INSULIN ANALOGUES |
| CZ310198B6 (cs) * | 2021-07-07 | 2024-11-13 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Deriváty inzulínu se zvýšenou tepelnou stabilitou |
| EP4405384A1 (en) | 2021-09-20 | 2024-07-31 | Kyon Biotech AG | Arginase-insulin fusion protein |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| KR900701842A (ko) | 1988-07-20 | 1990-12-04 | 헨리 브뢰늄 | 인간 인슐린 동족체와 그를 포함하는 제제 |
| US5716927A (en) | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| DE3844211A1 (de) | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| DE3936876A1 (de) | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK158390D0 (da) | 1990-07-02 | 1990-07-02 | Novo Nordisk As | Nye peptider |
| US5422339A (en) | 1991-03-19 | 1995-06-06 | Joslin Diabetes Center, Inc. | Peptides having insulin autoantibody but not insulin receptor binding capacity |
| TW224471B (https=) | 1991-11-26 | 1994-06-01 | Lilly Co Eli | |
| US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| US5547929A (en) | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US20030104981A1 (en) | 1995-11-03 | 2003-06-05 | Jelena Mandic | Human insulin analogues |
| DE19652713C2 (de) | 1996-12-18 | 2001-11-22 | Aventis Pharma Gmbh | Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| EA200000453A1 (ru) | 1997-10-24 | 2000-10-30 | Эли Лилли Энд Компани | Композиции нерастворимого инсулина |
| US6531448B1 (en) | 1997-12-23 | 2003-03-11 | Eli Lilly And Company | Insoluble compositions for controlling blood glucose |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| US7316999B2 (en) | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
| KR100449454B1 (ko) | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| AU2002346491A1 (en) | 2001-12-19 | 2003-07-09 | Eli Lilly And Company | Crystalline compositions for controlling blood glucose |
| PL374949A1 (en) | 2001-12-20 | 2005-11-14 | Eli Lilly And Company | Insulin molecule having protracted time action |
| AU2003226619A1 (en) | 2002-03-26 | 2003-10-08 | Council Of Scientific And Industrial Research | An adipocyte insulin and a method of treating diabetes |
| EP1523326A4 (en) | 2002-05-06 | 2009-09-09 | Univ Jefferson | INSULIN-ASSOCIATED PEPTIDES FOR IMPROVING BRAIN EFFECT |
| WO2004085472A1 (en) * | 2003-03-27 | 2004-10-07 | Novo Nordisk A/S | Method for making human insulin precursors and human insulin |
| US20060217290A1 (en) | 2003-04-29 | 2006-09-28 | Kohn Wayne D | Insulin analogs having protracted time action |
| CN1836047B (zh) | 2003-06-17 | 2010-12-22 | 赛姆生物系统遗传公司 | 在植物中生产胰岛素的方法 |
| CN1902226A (zh) * | 2003-12-03 | 2007-01-24 | 诺和诺德公司 | 单链胰岛素 |
| CN102660614A (zh) * | 2005-08-16 | 2012-09-12 | 诺沃-诺迪斯克有限公司 | 制备成熟胰岛素多肽的方法 |
| WO2007081824A2 (en) | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
| US20090069216A1 (en) | 2006-02-21 | 2009-03-12 | Novo Nordisk A/S | Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof |
| US8192857B2 (en) * | 2006-03-04 | 2012-06-05 | Enerdel, Inc. | Battery assembly and method of forming the same |
| EP2074140B8 (en) | 2006-10-04 | 2015-10-28 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| US7790677B2 (en) | 2006-12-13 | 2010-09-07 | Elona Biotechnologies | Insulin production methods and pro-insulin constructs |
| CN102007143B (zh) | 2008-01-09 | 2015-08-26 | 塞诺菲-安万特德国有限公司 | 具有超延迟时效特征的新型胰岛素衍生物 |
| US8993516B2 (en) | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| RU2010147076A (ru) * | 2008-04-22 | 2012-05-27 | Кейз Вестерн Ризев Юнивесити (Us) | Аналоги инсулина специфичные к изоформам |
| WO2009133099A2 (en) * | 2008-04-28 | 2009-11-05 | Novo Nordisk A/S | Insulin precursors for diabetes treatment |
| CA2732439A1 (en) | 2008-07-31 | 2010-02-04 | Case Western Reserve University | Halogen-stabilized insulin |
| US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| WO2011028813A2 (en) | 2009-09-01 | 2011-03-10 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
| US8399407B2 (en) | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| EA201200717A1 (ru) | 2009-12-11 | 2013-03-29 | Кейз Вестерн Ризев Юнивесити | Аналоги инсулина, содержащие хлорированные аминокислоты |
| CN102770153B (zh) | 2010-02-22 | 2014-05-07 | 卡斯西部储备大学 | 呈可溶和结晶形式的长效胰岛素类似物制剂 |
| EP2582719B1 (en) * | 2010-06-16 | 2016-08-10 | Indiana University Research and Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| MX2015005662A (es) | 2012-11-05 | 2015-08-20 | Univ Case Western Reserve | Analogos de insulina de una sola cadena de larga accion. |
-
2015
- 2015-10-06 AU AU2015328222A patent/AU2015328222B9/en active Active
- 2015-10-06 US US15/517,300 patent/US10392429B2/en active Active
- 2015-10-06 CA CA2961037A patent/CA2961037A1/en active Pending
- 2015-10-06 EP EP15849531.7A patent/EP3204410B1/en active Active
- 2015-10-06 KR KR1020177006438A patent/KR102569743B1/ko active Active
- 2015-10-06 JP JP2017518189A patent/JP6829928B2/ja active Active
- 2015-10-06 CN CN201580054329.9A patent/CN107108716A/zh active Pending
- 2015-10-06 WO PCT/US2015/054263 patent/WO2016057529A2/en not_active Ceased
- 2015-10-06 BR BR112017004544A patent/BR112017004544A2/pt not_active IP Right Cessation
-
2017
- 2017-04-02 IL IL251503A patent/IL251503A0/en unknown
-
2019
- 2019-08-26 US US16/550,973 patent/US11142560B2/en active Active
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