JP6817071B2 - 薬剤送達デバイス用の起動機構および薬剤送達デバイス - Google Patents
薬剤送達デバイス用の起動機構および薬剤送達デバイス Download PDFInfo
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- XVVOERDUTLJJHN-IAEQDCLQSA-N lixisenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 XVVOERDUTLJJHN-IAEQDCLQSA-N 0.000 description 1
- 108010004367 lixisenatide Proteins 0.000 description 1
- 229960001093 lixisenatide Drugs 0.000 description 1
- 230000000938 luteal effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- RWHUEXWOYVBUCI-ITQXDASVSA-N nafarelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 RWHUEXWOYVBUCI-ITQXDASVSA-N 0.000 description 1
- 229960002333 nafarelin Drugs 0.000 description 1
- 238000009828 non-uniform distribution Methods 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000013777 protein digestion Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
- A61M2005/247—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
2 カートリッジ
2.1 主本体部
2.1.1 カートリッジ肩部
2.2 首部
2.2.1 カートリッジフランジ
2.3 カートリッジ封止要素
3 栓
3.1 栓ノッチ
4 カートリッジキャリヤ
4.1 キャリヤリブ
4.2 遠位キャリヤ部
4.2.1 キャリヤカラー
4.3 キャリヤ突出部
4.4 キャリヤ封止ホイル
5 針キャップ
5.1 第1の間隙
5.2 第2の間隙
6 注射針
6.1 外側針部
6.2 内側針部
7 ピストンロッド
7.1 ロッド先端
8 スリーブ
D 遠位方向
L 長手方向軸
P 近位方向
P1 初期位置
P2 動作位置
x、y、z デカルト座標
Claims (11)
- 注射投与用薬剤送達デバイス(1)用の起動機構であって、起動機構は:
投与量の薬剤を含むカートリッジ(2)と、
該カートリッジ(2)を保持し、遠位キャリヤ部(4.2)を含むカートリッジキャリヤ(4)と、
該カートリッジキャリヤ(4)の遠位端内に配置された中空の注射針(6)であって、カートリッジキャリヤ(4)の内部に向けられた内側針部(6.2)を含み、それにより、薬剤送達デバイス(1)が使用前に使用者に提供される初期位置(P1)にあるとき、内側針部(6.2)がカートリッジ(2)から遠位方向(D)に離間される、中空の注射針と、
カートリッジキャリヤ(4)の外部に向けられた注射針(6)の外側針部(6.1)を覆い、封止する取り外し可能な針キャップ(5)と
を含み、ここで、
該針キャップ(5)が取り外され、カートリッジ(2)が遠位方向(D)に動かされると、遠位キャリヤ部(4.2)が半径方向外側に変形することができるように、少なくとも遠位キャリヤ部(4.2)は弾性材料から作られ、
遠位キャリヤ部(4.2)は、半径方向内側の方向ならびに半径方向外側の方向に突出するキャリヤカラー(4.2.1)を含み、
該キャリヤカラー(4.2.1)は、薬剤送達デバイス(1)が初期位置(P1)にある限り、カートリッジ(2)を適所に保持するように提供され、
起動機構は、カートリッジキャリヤ(4)にあらかじめ組み付けられた注射針(6)によってカートリッジ(2)の開封を可能とし、
薬剤送達デバイス(1)が初期位置(P1)にあるとき、遠位キャリヤ部(4.2)の半径方向外側の変形を制限するために、針キャップ(5)の近位の内面は遠位キャリヤ部(4.2)の半径方向外側の面にぴったりと合う、前記起動機構。 - 栓(3)と係合して栓(3)をカートリッジ(2)内で変位させるように適用されたピストンロッド(7)をさらに含み、ここで、栓(3)が近位方向(P)においてカートリッジ(2)の空洞を制限し、遠位面と近位面とを含む、請求項1に記載の起動機構。
- ピストンロッド(7)は、遠位端に、栓(3)の近位面内に配置され、対応して形成された栓ノッチ(3.1)内に係合するように適用されたロッド先端(7.1)を含む、請求項2に記載の起動機構。
- 薬剤送達デバイス(1)が初期位置(P1)にあるとき、ピストンロッド(7)はキャリヤ封止ホイル(4.4)から近位方向(P)に離間され、ここで、キャリア封止ホイル(4.4)は、カートリッジキャリア(4)の近位端を制限するコルクの中に配置された穿孔可能な封止膜として設計される、請求項3に記載の起動機構。
- キャリヤ封止ホイル(4.4)は、カートリッジキャリヤ(4)の開放された近位端全体に配置される、請求項4に記載の起動機構。
- キャリヤカラー(4.2.1)の内径は、カートリッジ(2)の最大外径より小さく、
キャリヤカラー(4.2.1)はカートリッジ肩部(2.2.1)と係合し、薬剤送達デバイス(1)が初期位置(P1)にあるとき、カートリッジ(2)のカートリッジキャリヤ(4)に対する遠位方向(D)の動きを制限する、
請求項1〜5のいずれか1項に記載の起動機構。 - 遠位キャリヤ部(4.2)の壁厚は、カートリッジキャリヤ(4)の近位側の壁厚に比べて小さい、請求項1〜6のいずれか1項に記載の起動機構。
- 針キャップ(5)は、薬剤送達デバイス(1)が初期位置(P1)にあるとき、外側針部(6.1)を囲む第1の間隙(5.1)を含み、
カートリッジキャリヤ(4)の遠位端に配置され、軸方向において遠位方向(D)に突出するキャリヤ突出部(4.3)の半径方向外側の面は、少なくとも遠位で第1の間隙(5.1)の近位の半径方向の面によって囲まれる、
請求項1〜7のいずれか1項に記載の起動機構。 - 外側針部(6.1)を被覆または露出するように、長手方向軸(L)に沿ってカートリッジキャリヤ(4)に対して可動であるスリーブ(8)をさらに含む、請求項1〜8のいずれか1項に記載の起動機構。
- 請求項1〜9のいずれか1項に記載の起動機構を含む薬剤送達デバイス(1)。
- カートリッジ(2)は、開放された遠位端全体に配置されるカートリッジ封止要素(2.3)によって遠位で封止され、栓(3)によって近位で封止される、請求項10に記載の薬剤送達デバイス(1)。
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EP14305686.9 | 2014-05-12 | ||
EP14305686.9A EP2944341A1 (en) | 2014-05-12 | 2014-05-12 | Activating mechanism for a medicament delivery device and medicament delivery device |
PCT/EP2015/060289 WO2015173167A1 (en) | 2014-05-12 | 2015-05-11 | Activating mechanism for a medicament delivery device and medicament delivery device |
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JP2019225000A Pending JP2020044374A (ja) | 2014-05-12 | 2019-12-13 | 薬剤送達デバイス用の起動機構および薬剤送達デバイス |
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US (2) | US10610645B2 (ja) |
EP (2) | EP2944341A1 (ja) |
JP (2) | JP6817071B2 (ja) |
CN (1) | CN106470719B (ja) |
DK (1) | DK3142729T3 (ja) |
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EP2944341A1 (en) | 2014-05-12 | 2015-11-18 | Sanofi | Activating mechanism for a medicament delivery device and medicament delivery device |
EP3302652B1 (en) | 2015-06-04 | 2023-09-06 | Medimop Medical Projects Ltd. | Cartridge insertion for drug delivery device |
US10799637B2 (en) | 2015-11-05 | 2020-10-13 | Sanofi-Aventis Deutschland Gmbh | Cartridge carrier assembly |
EP3380166A1 (en) * | 2015-11-27 | 2018-10-03 | Sanofi-Aventis Deutschland GmbH | Medicament injection device |
EP3380144A1 (en) * | 2015-11-27 | 2018-10-03 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device |
EP3315153A1 (en) * | 2016-10-25 | 2018-05-02 | Sanofi-Aventis Deutschland GmbH | Medicament injection device |
TWI668025B (zh) * | 2017-04-21 | 2019-08-11 | 瑞士商瑞健醫療股份有限公司 | 用於藥物輸送裝置的施用組合體 |
CN111278488A (zh) | 2017-10-30 | 2020-06-12 | 赛诺菲 | 注射器装置 |
US11857767B2 (en) | 2017-12-22 | 2024-01-02 | West Pharma. Services IL, Ltd. | Injector usable with different dimension cartridges |
CN111699014B (zh) * | 2018-02-19 | 2022-06-21 | 贝克顿迪金森法国公司 | 包括注射器和保护组件的注射系统 |
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DE2056688B1 (de) * | 1969-07-15 | 1972-03-23 | Woelm Fa M | Einmalspritze, die mit eingesetzter Ampulle sterilisierbar ist |
US3820652A (en) * | 1972-11-14 | 1974-06-28 | T Thackston | Packaged syringe construction |
US4303069A (en) * | 1978-10-30 | 1981-12-01 | Cohen Milton J | Hypodermic syringe with needle guide |
GB8630016D0 (en) * | 1986-12-16 | 1987-01-28 | Id Tech Ltd | Dental injection device |
JP3300533B2 (ja) * | 1993-06-07 | 2002-07-08 | 株式会社大塚製薬工場 | プレフィルドシリンジ |
JP2001017546A (ja) * | 1999-07-13 | 2001-01-23 | Terumo Corp | 薬液注入器具およびその製造方法 |
US8372044B2 (en) * | 2005-05-20 | 2013-02-12 | Safety Syringes, Inc. | Syringe with needle guard injection device |
US8162917B2 (en) | 2008-05-21 | 2012-04-24 | Onpharma, Inc. | Methods and apparatus for buffering anesthetics |
JPWO2011108575A1 (ja) | 2010-03-05 | 2013-06-27 | テルモ株式会社 | 医療器具 |
US9233209B2 (en) | 2010-08-27 | 2016-01-12 | Novo Nordisk A/S | Medical injection device |
GB201020472D0 (en) | 2010-12-02 | 2011-01-19 | Oval Medical Technologies Ltd | A drive assembly for an autoinjector |
EP2944341A1 (en) | 2014-05-12 | 2015-11-18 | Sanofi | Activating mechanism for a medicament delivery device and medicament delivery device |
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2014
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JP2020044374A (ja) | 2020-03-26 |
US10610645B2 (en) | 2020-04-07 |
DK3142729T3 (en) | 2018-10-01 |
EP3142729B1 (en) | 2018-06-20 |
WO2015173167A1 (en) | 2015-11-19 |
TW201600136A (zh) | 2016-01-01 |
EP2944341A1 (en) | 2015-11-18 |
EP3142729A1 (en) | 2017-03-22 |
CN106470719B (zh) | 2019-08-30 |
CN106470719A (zh) | 2017-03-01 |
US20200230322A1 (en) | 2020-07-23 |
US20170143903A1 (en) | 2017-05-25 |
US11826552B2 (en) | 2023-11-28 |
JP2017518799A (ja) | 2017-07-13 |
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