JP6799596B2 - ムスカリンｍ１及び／またはｍ４受容体のアゴニストとしてのオキシム化合物 - Google Patents

ムスカリンｍ１及び／またはｍ４受容体のアゴニストとしてのオキシム化合物 Download PDF

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JP6799596B2
JP6799596B2 JP2018522540A JP2018522540A JP6799596B2 JP 6799596 B2 JP6799596 B2 JP 6799596B2 JP 2018522540 A JP2018522540 A JP 2018522540A JP 2018522540 A JP2018522540 A JP 2018522540A JP 6799596 B2 JP6799596 B2 JP 6799596B2
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ethyl
piperidine
carboxylate
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JP2018536653A5 (enExample
JP2018536653A (ja
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ブラウン，ジャイルズ・アルバート
テハン，ベンジャミン・ジェラルド
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Nxera Pharma UK Ltd
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Heptares Therapeutics Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2018522540A 2015-11-02 2016-11-02 ムスカリンｍ１及び／またはｍ４受容体のアゴニストとしてのオキシム化合物 Active JP6799596B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1519352.7 2015-11-02
GBGB1519352.7A GB201519352D0 (en) 2015-11-02 2015-11-02 Pharmaceutical compounds
PCT/GB2016/053396 WO2017077292A1 (en) 2015-11-02 2016-11-02 Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor

Publications (3)

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JP2018536653A JP2018536653A (ja) 2018-12-13
JP2018536653A5 JP2018536653A5 (enExample) 2019-09-05
JP6799596B2 true JP6799596B2 (ja) 2020-12-23

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JP2018522540A Active JP6799596B2 (ja) 2015-11-02 2016-11-02 ムスカリンｍ１及び／またはｍ４受容体のアゴニストとしてのオキシム化合物

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Country Link
US (2) US11208396B2 (enExample)
EP (2) EP3370828B1 (enExample)
JP (1) JP6799596B2 (enExample)
CN (1) CN108290055B (enExample)
AU (1) AU2016348847B2 (enExample)
CA (1) CA3003669C (enExample)
DK (1) DK3370828T3 (enExample)
ES (1) ES2804774T3 (enExample)
GB (1) GB201519352D0 (enExample)
WO (1) WO2017077292A1 (enExample)

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CN106831541B (zh) 2011-11-18 2019-09-06 赫普泰雅治疗有限公司 毒蕈碱性m1受体激动剂
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WO2017107089A1 (en) 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
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WO2018112842A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
WO2018112843A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
GB201709652D0 (en) * 2017-06-16 2017-08-02 Heptares Therapeutics Ltd Pharmaceutical compounds
JP7166331B2 (ja) * 2017-08-01 2022-11-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中間体化合物及び方法
US11149022B2 (en) 2017-10-17 2021-10-19 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
JP2021503443A (ja) * 2017-10-31 2021-02-12 ヴァンダービルト ユニバーシティー ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
KR102798432B1 (ko) 2019-10-09 2025-04-22 노파르티스 아게 M4 작용제로서의 5-옥사-2-아자스피로[3.4]옥탄 유도체
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GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
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Publication number Publication date
EP3797778A1 (en) 2021-03-31
JP2018536653A (ja) 2018-12-13
US20220298133A1 (en) 2022-09-22
AU2016348847A1 (en) 2018-06-07
AU2016348847B2 (en) 2021-07-08
ES2804774T3 (es) 2021-02-09
CN108290055A (zh) 2018-07-17
EP3370828B1 (en) 2020-04-15
DK3370828T3 (da) 2020-07-13
WO2017077292A1 (en) 2017-05-11
CN108290055B (zh) 2021-05-14
GB201519352D0 (en) 2015-12-16
HK1253036A1 (en) 2019-06-06
US20200165220A1 (en) 2020-05-28
EP3370828A1 (en) 2018-09-12
US11208396B2 (en) 2021-12-28
US12291512B2 (en) 2025-05-06
CA3003669A1 (en) 2017-05-11
CA3003669C (en) 2024-04-09

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