CA3003669C - Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor - Google Patents

Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor Download PDF

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Publication number
CA3003669C
CA3003669C CA3003669A CA3003669A CA3003669C CA 3003669 C CA3003669 C CA 3003669C CA 3003669 A CA3003669 A CA 3003669A CA 3003669 A CA3003669 A CA 3003669A CA 3003669 C CA3003669 C CA 3003669C
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CA
Canada
Prior art keywords
ethyl
carboxylate
azepane
compound according
piperidin
Prior art date
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Active
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CA3003669A
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English (en)
French (fr)
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CA3003669A1 (en
Inventor
Giles Albert Brown
Benjamin Gerald TEHAN
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Nxera Pharma UK Ltd
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Heptares Therapeutics Ltd
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Publication of CA3003669A1 publication Critical patent/CA3003669A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3003669A 2015-11-02 2016-11-02 Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor Active CA3003669C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1519352.7A GB201519352D0 (en) 2015-11-02 2015-11-02 Pharmaceutical compounds
GB1519352.7 2015-11-02
PCT/GB2016/053396 WO2017077292A1 (en) 2015-11-02 2016-11-02 Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor

Publications (2)

Publication Number Publication Date
CA3003669A1 CA3003669A1 (en) 2017-05-11
CA3003669C true CA3003669C (en) 2024-04-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3003669A Active CA3003669C (en) 2015-11-02 2016-11-02 Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor

Country Status (10)

Country Link
US (2) US11208396B2 (enExample)
EP (2) EP3370828B1 (enExample)
JP (1) JP6799596B2 (enExample)
CN (1) CN108290055B (enExample)
AU (1) AU2016348847B2 (enExample)
CA (1) CA3003669C (enExample)
DK (1) DK3370828T3 (enExample)
ES (1) ES2804774T3 (enExample)
GB (1) GB201519352D0 (enExample)
WO (1) WO2017077292A1 (enExample)

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CA3079188A1 (en) * 2017-10-17 2019-04-25 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
US11299481B2 (en) 2017-10-20 2022-04-12 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
EP3703680B1 (en) * 2017-10-31 2024-05-15 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
KR102798432B1 (ko) 2019-10-09 2025-04-22 노파르티스 아게 M4 작용제로서의 5-옥사-2-아자스피로[3.4]옥탄 유도체
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AU2016348847B2 (en) 2021-07-08
JP2018536653A (ja) 2018-12-13
CN108290055B (zh) 2021-05-14
CN108290055A (zh) 2018-07-17
ES2804774T3 (es) 2021-02-09
GB201519352D0 (en) 2015-12-16
WO2017077292A1 (en) 2017-05-11
DK3370828T3 (da) 2020-07-13
EP3797778A1 (en) 2021-03-31
HK1253036A1 (en) 2019-06-06
JP6799596B2 (ja) 2020-12-23
AU2016348847A1 (en) 2018-06-07
EP3370828A1 (en) 2018-09-12
US12291512B2 (en) 2025-05-06
US20220298133A1 (en) 2022-09-22
US20200165220A1 (en) 2020-05-28
EP3370828B1 (en) 2020-04-15
CA3003669A1 (en) 2017-05-11
US11208396B2 (en) 2021-12-28

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