CA3003669C - Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor - Google Patents
Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor Download PDFInfo
- Publication number
- CA3003669C CA3003669C CA3003669A CA3003669A CA3003669C CA 3003669 C CA3003669 C CA 3003669C CA 3003669 A CA3003669 A CA 3003669A CA 3003669 A CA3003669 A CA 3003669A CA 3003669 C CA3003669 C CA 3003669C
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- Prior art keywords
- ethyl
- carboxylate
- azepane
- compound according
- piperidin
- Prior art date
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- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 19
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/GB2016/053396 WO2017077292A1 (en) | 2015-11-02 | 2016-11-02 | Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor |
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| WO2017107089A1 (en) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor |
| ES2789756T3 (es) | 2015-12-23 | 2020-10-26 | Merck Sharp & Dohme | Moduladores alostéricos de 6,7-dihidro-5H-pirrolo[3,4-b]piridin-5-ona del receptor de acetilcolina muscarínico M4 |
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| WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
| WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
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| EP3697781B1 (en) * | 2017-10-17 | 2023-06-07 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
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| US4369184A (en) | 1980-01-24 | 1983-01-18 | Janssen Pharmaceutica N.V. | 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives |
| US5852029A (en) | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
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| US5446051A (en) | 1994-05-31 | 1995-08-29 | Eli Lilly And Company | Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists |
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| ES2804774T3 (es) | 2021-02-09 |
| JP2018536653A (ja) | 2018-12-13 |
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| CA3003669A1 (en) | 2017-05-11 |
| EP3370828B1 (en) | 2020-04-15 |
| EP3370828A1 (en) | 2018-09-12 |
| WO2017077292A1 (en) | 2017-05-11 |
| US11208396B2 (en) | 2021-12-28 |
| JP6799596B2 (ja) | 2020-12-23 |
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