DK3370828T3 - Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren - Google Patents

Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren Download PDF

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Publication number
DK3370828T3
DK3370828T3 DK16793975.0T DK16793975T DK3370828T3 DK 3370828 T3 DK3370828 T3 DK 3370828T3 DK 16793975 T DK16793975 T DK 16793975T DK 3370828 T3 DK3370828 T3 DK 3370828T3
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Denmark
Prior art keywords
muscarin
agonists
receptor
oxim
compound
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DK16793975.0T
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Danish (da)
English (en)
Inventor
Giles Albert Brown
Benjamin Gerald Tehan
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Heptares Therapeutics Ltd
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Publication of DK3370828T3 publication Critical patent/DK3370828T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK16793975.0T 2015-11-02 2016-11-02 Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren DK3370828T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1519352.7A GB201519352D0 (en) 2015-11-02 2015-11-02 Pharmaceutical compounds
PCT/GB2016/053396 WO2017077292A1 (en) 2015-11-02 2016-11-02 Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor

Publications (1)

Publication Number Publication Date
DK3370828T3 true DK3370828T3 (da) 2020-07-13

Family

ID=55130557

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16793975.0T DK3370828T3 (da) 2015-11-02 2016-11-02 Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren

Country Status (10)

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US (2) US11208396B2 (enExample)
EP (2) EP3797778A1 (enExample)
JP (1) JP6799596B2 (enExample)
CN (1) CN108290055B (enExample)
AU (1) AU2016348847B2 (enExample)
CA (1) CA3003669C (enExample)
DK (1) DK3370828T3 (enExample)
ES (1) ES2804774T3 (enExample)
GB (1) GB201519352D0 (enExample)
WO (1) WO2017077292A1 (enExample)

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AU2018300980A1 (en) 2017-07-12 2020-01-02 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
JP7166331B2 (ja) * 2017-08-01 2022-11-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中間体化合物及び方法
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GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
CN114555592B (zh) 2019-10-09 2024-09-06 诺华股份有限公司 作为m4激动剂的2-氮杂螺[3.4]辛烷衍生物
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GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
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GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202103211D0 (en) 2021-03-08 2021-04-21 Heptares Therapeutics Ltd Pharmaceutical compounds for use in therapy

Also Published As

Publication number Publication date
CN108290055B (zh) 2021-05-14
US12291512B2 (en) 2025-05-06
GB201519352D0 (en) 2015-12-16
US20220298133A1 (en) 2022-09-22
AU2016348847B2 (en) 2021-07-08
EP3370828A1 (en) 2018-09-12
EP3797778A1 (en) 2021-03-31
US20200165220A1 (en) 2020-05-28
CA3003669A1 (en) 2017-05-11
EP3370828B1 (en) 2020-04-15
CA3003669C (en) 2024-04-09
US11208396B2 (en) 2021-12-28
CN108290055A (zh) 2018-07-17
HK1253036A1 (en) 2019-06-06
WO2017077292A1 (en) 2017-05-11
JP2018536653A (ja) 2018-12-13
AU2016348847A1 (en) 2018-06-07
ES2804774T3 (es) 2021-02-09
JP6799596B2 (ja) 2020-12-23

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