JP6782227B2 - ＣａＭＫＩＩ阻害剤及びその使用 - Google Patents

ＣａＭＫＩＩ阻害剤及びその使用 Download PDF

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JP6782227B2
JP6782227B2 JP2017512313A JP2017512313A JP6782227B2 JP 6782227 B2 JP6782227 B2 JP 6782227B2 JP 2017512313 A JP2017512313 A JP 2017512313A JP 2017512313 A JP2017512313 A JP 2017512313A JP 6782227 B2 JP6782227 B2 JP 6782227B2
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hydrogen
independently
compound
nitrogen
sulfur
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JP2017534572A (ja
JP2017534572A5 (enExample
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ダニエル イー． レビー，
ダニエル イー． レビー，
ハワード シュルマン，
ハワード シュルマン，
ビーマ ラオ パラセッリ，
ビーマ ラオ パラセッリ，
ナングノーリ サンパス クマール，
ナングノーリ サンパス クマール，
ブラーマイアー ダッブゴッドゥ，
ブラーマイアー ダッブゴッドゥ，
チュンドル バラスブラマンヤム，
チュンドル バラスブラマンヤム，
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ザ・ジョンズ・ホプキンス・ユニバーシティー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2017512313A 2014-09-05 2015-09-04 ＣａＭＫＩＩ阻害剤及びその使用 Active JP6782227B2 (ja)

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JP2020097823A JP6918378B2 (ja) 2014-09-05 2020-06-04 ＣａＭＫＩＩ阻害剤及びその使用

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US201462046450P 2014-09-05 2014-09-05
US62/046,450 2014-09-05
PCT/US2015/048640 WO2016037106A1 (en) 2014-09-05 2015-09-04 CaMKII INHIBITORS AND USES THEREOF

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JP2017534572A5 JP2017534572A5 (enExample) 2018-10-11
JP6782227B2 true JP6782227B2 (ja) 2020-11-11

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JP2020097823A Expired - Fee Related JP6918378B2 (ja) 2014-09-05 2020-06-04 ＣａＭＫＩＩ阻害剤及びその使用

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US (2) US10759792B2 (enExample)
EP (1) EP3189052B1 (enExample)
JP (2) JP6782227B2 (enExample)
CN (1) CN107074856A (enExample)
AU (2) AU2015311730A1 (enExample)
CA (1) CA2960101C (enExample)
WO (1) WO2016037106A1 (enExample)

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AR110252A1 (es) 2016-11-30 2019-03-13 Gilead Sciences Inc Compuestos heterocíclicos fusionados como inhibidores de la quinasa cam
WO2019049148A1 (en) * 2017-09-10 2019-03-14 Carmel Haifa University Economic Corporation Ltd. METHOD OF TREATING DEPRESSION AND MAJOR DEPRESSIVE DISORDER
CN108218862B (zh) * 2018-02-07 2020-06-23 贵州医科大学 α-卡波林类衍生物在制备抗心肌缺氧复氧损伤药物中的应用
JP7500426B2 (ja) 2018-02-21 2024-06-17 ブリストル－マイヤーズ スクイブ カンパニー Ｃａｍｋ２ｄアンチセンスオリゴヌクレオチドおよびその使用
CN108904532B (zh) * 2018-08-20 2021-07-27 上海市第一人民医院 一种富勒烯C60纳米晶体联合CaMKII抑制剂的组合物的应用
EP3887371B1 (en) * 2018-11-27 2023-02-22 F. Hoffmann-La Roche AG Aryl compounds for the treatment and prophylaxis of bacterial infection
MX2023003610A (es) * 2020-09-28 2023-07-20 Cardurion Pharmaceuticals Inc Compuestos de heteroarilo fusionado y su uso como inhibidores de proteína cinasa ii dependiente de calcio/calmodulina (camkii).

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BE758991A (fr) * 1969-11-18 1971-05-17 Reeves Bros Inc Procede de reticulation hydrodynamique d'une mousse de polyurethanne
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Publication number Publication date
AU2020203927B2 (en) 2021-06-24
WO2016037106A1 (en) 2016-03-10
US20170247374A1 (en) 2017-08-31
JP2017534572A (ja) 2017-11-24
JP2020143161A (ja) 2020-09-10
CN107074856A (zh) 2017-08-18
AU2015311730A1 (en) 2017-04-20
CA2960101C (en) 2024-05-21
EP3189052A1 (en) 2017-07-12
JP6918378B2 (ja) 2021-08-11
US11325908B2 (en) 2022-05-10
US10759792B2 (en) 2020-09-01
AU2020203927B9 (en) 2021-07-08
EP3189052B1 (en) 2021-11-03
AU2015311730A8 (en) 2017-05-11
US20200385383A1 (en) 2020-12-10
CA2960101A1 (en) 2016-03-10
AU2020203927A1 (en) 2020-07-02

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