JP6755457B2 - 合成アミノ酸の癌細胞内取り込みを保持する修飾法と正常細胞を保護する中性子捕捉療法 - Google Patents

合成アミノ酸の癌細胞内取り込みを保持する修飾法と正常細胞を保護する中性子捕捉療法 Download PDF

Info

Publication number
JP6755457B2
JP6755457B2 JP2018510659A JP2018510659A JP6755457B2 JP 6755457 B2 JP6755457 B2 JP 6755457B2 JP 2018510659 A JP2018510659 A JP 2018510659A JP 2018510659 A JP2018510659 A JP 2018510659A JP 6755457 B2 JP6755457 B2 JP 6755457B2
Authority
JP
Japan
Prior art keywords
boron
amino acid
containing compound
cancer
transport system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018510659A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2017175827A1 (ja
Inventor
良夫 今堀
良夫 今堀
仁 遠藤
仁 遠藤
藤井 亮
亮 藤井
艶子 竹吉
艶子 竹吉
有貴 伏見
有貴 伏見
大 辻川
大 辻川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CANCER INTELLIGENCE CARE SYSTEMS Inc
Original Assignee
CANCER INTELLIGENCE CARE SYSTEMS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CANCER INTELLIGENCE CARE SYSTEMS Inc filed Critical CANCER INTELLIGENCE CARE SYSTEMS Inc
Publication of JPWO2017175827A1 publication Critical patent/JPWO2017175827A1/ja
Application granted granted Critical
Publication of JP6755457B2 publication Critical patent/JP6755457B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/22Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2018510659A 2016-04-08 2017-04-06 合成アミノ酸の癌細胞内取り込みを保持する修飾法と正常細胞を保護する中性子捕捉療法 Active JP6755457B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016078453 2016-04-08
JP2016078453 2016-04-08
PCT/JP2017/014366 WO2017175827A1 (ja) 2016-04-08 2017-04-06 合成アミノ酸の癌細胞内取り込みを保持する修飾法と正常細胞を保護する中性子捕捉療法

Publications (2)

Publication Number Publication Date
JPWO2017175827A1 JPWO2017175827A1 (ja) 2019-02-21
JP6755457B2 true JP6755457B2 (ja) 2020-09-16

Family

ID=60001199

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018510659A Active JP6755457B2 (ja) 2016-04-08 2017-04-06 合成アミノ酸の癌細胞内取り込みを保持する修飾法と正常細胞を保護する中性子捕捉療法

Country Status (3)

Country Link
JP (1) JP6755457B2 (zh)
TW (1) TW201735929A (zh)
WO (1) WO2017175827A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2721845C2 (ru) * 2015-12-30 2020-05-25 Нойборон Медтех Лтд. СОЕДИНЕНИЕ ДЛЯ СПЕЦИФИЧЕСКОГО СВЯЗЫВАНИЯ С β-АМИЛОИДОМ
WO2021040042A1 (ja) * 2019-08-30 2021-03-04 ジェイファーマ株式会社 特定の遺伝子マーカーを有する患者に用いるがん治療用の医薬組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004233168A (ja) * 2003-01-29 2004-08-19 Japan Science & Technology Agency 中性子捕捉療法に用いる中性子遮蔽板、およびヒト以外の哺乳動物に対して行なう中性子捕捉療法、ならびに治療用中性子照射装置
JP4863345B2 (ja) * 2005-03-18 2012-01-25 国立大学法人金沢大学 心筋用放射性画像診断剤又は放射性治療薬
JP6253008B2 (ja) * 2013-08-27 2017-12-27 国立大学法人 筑波大学 高分子化ホウ素化合物及びその使用

Also Published As

Publication number Publication date
JPWO2017175827A1 (ja) 2019-02-21
WO2017175827A1 (ja) 2017-10-12
TW201735929A (zh) 2017-10-16

Similar Documents

Publication Publication Date Title
van Malenstein et al. A randomized phase II study of drug-eluting beads versus transarterial chemoembolization for unresectable hepatocellular carcinoma
Aft et al. Enhancing targeted radiotherapy by copper (II) diacetyl-bis (N 4-methylthiosemicarbazone) using 2-deoxy-D-glucose
Miyatake et al. Pseudoprogression in boron neutron capture therapy for malignant gliomas and meningiomas
JP2016527202A (ja) 癌の治療方法
JP6755457B2 (ja) 合成アミノ酸の癌細胞内取り込みを保持する修飾法と正常細胞を保護する中性子捕捉療法
CN113616818B (zh) 一种用于肿瘤的靶向放射与免疫联合治疗的药物组合物
JP6789991B2 (ja) 癌の早期骨転移の画像診断剤
Sathekge Targeted radionuclide therapy
Viertl et al. Increase of [18 F] FLT tumor uptake in vivo mediated by FdUrd: Toward improving cell proliferation positron emission tomography
JP2019001761A (ja) 腫瘍イメージング剤、及びホウ素中性子捕捉療法用腫瘍治療剤
Yusufi et al. Comparative preclinical biodistribution, dosimetry and endoradiotherapy in mCRPC using 19F/177Lu-rhPSMA-7.3 and 177Lu-PSMA I&T
Hwang et al. 131I-labeled chitosan hydrogels for radioembolization: A preclinical study in small animals
Tanaka et al. Effect of intermittent and daily regimens of minodronic acid on bone metabolism in an ovariectomized rat model of osteoporosis
US8268888B2 (en) Therapy of malignant neoplasias
AU2020356262B2 (en) Radiolabelled GRPR-antagonist for use as theragnostic
WO2023073603A1 (en) Combination therapy of radionuclide complex
JP6598395B2 (ja) ホウ素アミノ酸を含む静注用製剤及びホウ素中性子捕捉療法
JP2023149495A (ja) L型アミノ酸トランスポーター1特異的化合物の製造方法
JP2020180049A (ja) fluciclovineによる肝癌イメージング
WO2004071505A2 (en) Radiolabelled d-amino acids for use in diagnosis with spect and pet and systemic radionuclide therapy
JP2016210688A (ja) 放射性抗腫瘍剤、及び、抗腫瘍用キット

Legal Events

Date Code Title Description
A529 Written submission of copy of amendment under article 34 pct

Free format text: JAPANESE INTERMEDIATE CODE: A5211

Effective date: 20181002

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20181002

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190220

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200114

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200316

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200623

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200703

R150 Certificate of patent or registration of utility model

Ref document number: 6755457

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250