JP6748086B2 - 抗トランスサイレチン抗体 - Google Patents

抗トランスサイレチン抗体 Download PDF

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Publication number
JP6748086B2
JP6748086B2 JP2017539650A JP2017539650A JP6748086B2 JP 6748086 B2 JP6748086 B2 JP 6748086B2 JP 2017539650 A JP2017539650 A JP 2017539650A JP 2017539650 A JP2017539650 A JP 2017539650A JP 6748086 B2 JP6748086 B2 JP 6748086B2
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Japan
Prior art keywords
antibody
seq
ttr
variable region
heavy chain
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English (en)
Japanese (ja)
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JP2018506277A (ja
JP2018506277A5 (https=
Inventor
リュウ，ユエ
エス． ニハル，ターロチャン
エス． ニハル，ターロチャン
チャクラバーティー，アビジット
エヌ． ヒガキ，ジェフェリー
エヌ． ヒガキ，ジェフェリー
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Prothena Biosciences Ltd
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Neotope Biosciences Ltd
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Publication of JP2018506277A5 publication Critical patent/JP2018506277A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017539650A 2015-01-28 2016-01-28 抗トランスサイレチン抗体 Active JP6748086B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562109002P 2015-01-28 2015-01-28
US62/109,002 2015-01-28
US201562266556P 2015-12-11 2015-12-11
US62/266,556 2015-12-11
PCT/IB2016/050415 WO2016120810A1 (en) 2015-01-28 2016-01-28 Anti-transthyretin antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020133642A Division JP7028923B2 (ja) 2015-01-28 2020-08-06 抗トランスサイレチン抗体

Publications (3)

Publication Number Publication Date
JP2018506277A JP2018506277A (ja) 2018-03-08
JP2018506277A5 JP2018506277A5 (https=) 2019-03-07
JP6748086B2 true JP6748086B2 (ja) 2020-09-02

Family

ID=55299694

Family Applications (2)

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JP2017539650A Active JP6748086B2 (ja) 2015-01-28 2016-01-28 抗トランスサイレチン抗体
JP2020133642A Active JP7028923B2 (ja) 2015-01-28 2020-08-06 抗トランスサイレチン抗体

Family Applications After (1)

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JP2020133642A Active JP7028923B2 (ja) 2015-01-28 2020-08-06 抗トランスサイレチン抗体

Country Status (31)

Country Link
US (1) US20160251418A1 (https=)
EP (2) EP4134379A1 (https=)
JP (2) JP6748086B2 (https=)
KR (2) KR102598180B1 (https=)
CN (1) CN107406499B (https=)
AU (1) AU2016210888C1 (https=)
CA (1) CA2974912A1 (https=)
CL (2) CL2017001924A1 (https=)
CO (1) CO2017008476A2 (https=)
CU (1) CU24480B1 (https=)
DK (1) DK3250592T3 (https=)
EA (1) EA036080B1 (https=)
ES (1) ES2934656T3 (https=)
FI (1) FI3250592T3 (https=)
HR (1) HRP20221538T1 (https=)
HU (1) HUE060878T2 (https=)
IL (1) IL253633B (https=)
LT (1) LT3250592T (https=)
MX (1) MX394170B (https=)
PE (1) PE20180217A1 (https=)
PH (1) PH12017501318A1 (https=)
PL (1) PL3250592T3 (https=)
PT (1) PT3250592T (https=)
RS (1) RS63906B1 (https=)
SA (1) SA517382002B1 (https=)
SG (2) SG10202101763VA (https=)
SI (1) SI3250592T1 (https=)
TW (2) TWI786505B (https=)
UA (1) UA122142C2 (https=)
WO (1) WO2016120810A1 (https=)
ZA (1) ZA201705663B (https=)

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US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
WO2018007922A2 (en) * 2016-07-02 2018-01-11 Prothena Biosciences Limited Anti-transthyretin antibodies
CU24731B1 (es) 2017-10-06 2025-01-15 Prothena Biosciences Ltd Anticuerpos anti-transtiretina
AU2018345807B2 (en) 2017-10-06 2025-02-06 Novo Nordisk A/S Methods of detecting transthyretin
PE20211453A1 (es) * 2017-11-29 2021-08-05 Prothena Biosciences Ltd Formulacion liofilizada de un anticuerpo monoclonal contra transtirretina
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CN113845593B (zh) * 2021-10-27 2023-03-10 福州迈新生物技术开发有限公司 抗α-SMA蛋白单克隆抗体、细胞系及其应用
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EP4619431A1 (en) 2022-11-15 2025-09-24 Neurimmune AG Methods for treating or preventing transthyretin-mediated amyloidosis
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EP4713354A1 (en) 2023-05-19 2026-03-25 Neurimmune AG Novel immunotherapy for musculoskeletal disorders and conditions
AR134366A1 (es) 2023-11-15 2026-01-07 Neurimmune Ag Anticuerpo antitranstiretina, composiciones que comprenden dicho anticuerpo y métodos para tratar o prevenir la amiloidosis mediada por transtiretina
AR134700A1 (es) 2023-12-15 2026-03-04 Novo Nordisk As Formulaciones líquidas estables
WO2025238147A1 (en) 2024-05-15 2025-11-20 Neurimmune Ag Maintenance treatment of cardiac ttr amyloidosis using anti-transthyretin antibodies

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Also Published As

Publication number Publication date
CN107406499A (zh) 2017-11-28
TWI786505B (zh) 2022-12-11
PT3250592T (pt) 2022-12-28
EP4134379A1 (en) 2023-02-15
CA2974912A1 (en) 2016-08-04
PH12017501318B1 (en) 2018-02-05
WO2016120810A1 (en) 2016-08-04
CO2017008476A2 (es) 2018-01-16
FI3250592T3 (fi) 2023-01-13
KR20170106469A (ko) 2017-09-20
SA517382002B1 (ar) 2021-11-25
JP2020185009A (ja) 2020-11-19
SG11201706124VA (en) 2017-08-30
TW201632554A (zh) 2016-09-16
JP2018506277A (ja) 2018-03-08
US20160251418A1 (en) 2016-09-01
SI3250592T1 (sl) 2023-03-31
PH12017501318A1 (en) 2018-02-05
CU20170097A7 (es) 2018-03-13
IL253633A0 (en) 2017-09-28
EP3250592A1 (en) 2017-12-06
HUE060878T2 (hu) 2023-04-28
PL3250592T3 (pl) 2023-06-19
CU24480B1 (es) 2020-03-04
AU2016210888C1 (en) 2022-06-02
SG10202101763VA (en) 2021-04-29
HRP20221538T1 (hr) 2023-03-03
MX2017009806A (es) 2018-08-15
AU2016210888B2 (en) 2021-11-04
CL2022003027A1 (es) 2023-06-09
KR102677203B1 (ko) 2024-06-20
BR112017016330A2 (en) 2018-04-03
JP7028923B2 (ja) 2022-03-02
TWI718122B (zh) 2021-02-11
RS63906B1 (sr) 2023-02-28
PE20180217A1 (es) 2018-01-31
AU2016210888A1 (en) 2017-08-10
EP3250592B1 (en) 2022-10-05
IL253633B (en) 2021-06-30
EA036080B1 (ru) 2020-09-23
ZA201705663B (en) 2018-08-29
KR20230156164A (ko) 2023-11-13
EA201791712A1 (ru) 2017-12-29
MX394170B (es) 2025-03-24
KR102598180B1 (ko) 2023-11-03
TW202124436A (zh) 2021-07-01
ES2934656T3 (es) 2023-02-23
UA122142C2 (uk) 2020-09-25
CN107406499B (zh) 2021-10-22
NZ733896A (en) 2024-11-29
DK3250592T3 (en) 2023-01-09
CL2017001924A1 (es) 2018-04-27
LT3250592T (lt) 2023-02-10

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