JP6739335B2 - ゲノムエンジニアリング - Google Patents

ゲノムエンジニアリング Download PDF

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JP6739335B2
JP6739335B2 JP2016530062A JP2016530062A JP6739335B2 JP 6739335 B2 JP6739335 B2 JP 6739335B2 JP 2016530062 A JP2016530062 A JP 2016530062A JP 2016530062 A JP2016530062 A JP 2016530062A JP 6739335 B2 JP6739335 B2 JP 6739335B2
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dna
cell
nucleic acid
cells
enzyme
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JP2016528894A (ja
JP2016528894A5 (enExample
Inventor
ジョージ エム． チャーチ、
ジョージ エム． チャーチ、
ルハン ヤン、
ルハン ヤン、
マーク グエル カーゴル、
マーク グエル カーゴル、
ジョイス リチ ヤン、
ジョイス リチ ヤン、
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
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    • C12N2510/00—Genetically modified cells
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
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    • C12N2800/00—Nucleic acids vectors
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible

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  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
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  • Molecular Biology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2016530062A 2013-07-26 2014-07-25 ゲノムエンジニアリング Active JP6739335B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361858866P 2013-07-26 2013-07-26
US61/858,866 2013-07-26
PCT/US2014/048140 WO2015013583A2 (en) 2013-07-26 2014-07-25 Genome engineering

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020028641A Division JP6993063B2 (ja) 2013-07-26 2020-02-21 ゲノムエンジニアリング

Publications (3)

Publication Number Publication Date
JP2016528894A JP2016528894A (ja) 2016-09-23
JP2016528894A5 JP2016528894A5 (enExample) 2017-07-20
JP6739335B2 true JP6739335B2 (ja) 2020-08-12

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JP2016530062A Active JP6739335B2 (ja) 2013-07-26 2014-07-25 ゲノムエンジニアリング
JP2020028641A Active JP6993063B2 (ja) 2013-07-26 2020-02-21 ゲノムエンジニアリング
JP2021198648A Active JP7419328B2 (ja) 2013-07-26 2021-12-07 ゲノムエンジニアリング
JP2024002064A Pending JP2024029218A (ja) 2013-07-26 2024-01-10 ゲノムエンジニアリング

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JP2020028641A Active JP6993063B2 (ja) 2013-07-26 2020-02-21 ゲノムエンジニアリング
JP2021198648A Active JP7419328B2 (ja) 2013-07-26 2021-12-07 ゲノムエンジニアリング
JP2024002064A Pending JP2024029218A (ja) 2013-07-26 2024-01-10 ゲノムエンジニアリング

Country Status (13)

Country Link
US (4) US11306328B2 (enExample)
EP (4) EP4234703A3 (enExample)
JP (4) JP6739335B2 (enExample)
KR (2) KR102773555B1 (enExample)
CN (3) CN105473773B (enExample)
AU (4) AU2014293015B2 (enExample)
BR (1) BR112016001721B1 (enExample)
CA (1) CA2918540A1 (enExample)
ES (1) ES2715666T3 (enExample)
IL (2) IL243560B (enExample)
RU (2) RU2688462C2 (enExample)
SG (3) SG11201600217QA (enExample)
WO (1) WO2015013583A2 (enExample)

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