JP6709780B2 - 官能性双性イオン性ポリマーおよび混合電荷ポリマー、関連するヒドロゲルならびにこれらの使用方法 - Google Patents

官能性双性イオン性ポリマーおよび混合電荷ポリマー、関連するヒドロゲルならびにこれらの使用方法 Download PDF

Info

Publication number
JP6709780B2
JP6709780B2 JP2017513127A JP2017513127A JP6709780B2 JP 6709780 B2 JP6709780 B2 JP 6709780B2 JP 2017513127 A JP2017513127 A JP 2017513127A JP 2017513127 A JP2017513127 A JP 2017513127A JP 6709780 B2 JP6709780 B2 JP 6709780B2
Authority
JP
Japan
Prior art keywords
polymer
functional groups
cells
hydrogel
nucleus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017513127A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017527669A5 (https=
JP2017527669A (ja
Inventor
ジャン,シャオイー
バイ,タオ
サブラマニアン サンダラーム,ハリハラ
サブラマニアン サンダラーム,ハリハラ
シンクレア,アンドリュー,ウィリアム
エラ−メニェ,ジャン−ルネ
ジャイン,プリイェシュ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Publication of JP2017527669A publication Critical patent/JP2017527669A/ja
Publication of JP2017527669A5 publication Critical patent/JP2017527669A5/ja
Application granted granted Critical
Publication of JP6709780B2 publication Critical patent/JP6709780B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0031Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/16Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/06Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145Hydrogels or hydrocolloids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10Esters
    • C08F220/34Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • C08F220/36Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate
    • C08F220/365Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate containing further carboxylic moieties
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C08G81/02Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • C08G81/021Block or graft polymers containing only sequences of polymers of C08C or C08F
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2539/00Supports and/or coatings for cell culture characterised by properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2017513127A 2014-09-09 2015-09-09 官能性双性イオン性ポリマーおよび混合電荷ポリマー、関連するヒドロゲルならびにこれらの使用方法 Active JP6709780B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462048155P 2014-09-09 2014-09-09
US62/048,155 2014-09-09
PCT/US2015/049197 WO2016040489A1 (en) 2014-09-09 2015-09-09 Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methds for their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020090650A Division JP2020139163A (ja) 2014-09-09 2020-05-25 官能性双性イオン性ポリマーおよび混合電荷ポリマー、関連するヒドロゲルならびにこれらの使用方法

Publications (3)

Publication Number Publication Date
JP2017527669A JP2017527669A (ja) 2017-09-21
JP2017527669A5 JP2017527669A5 (https=) 2018-10-11
JP6709780B2 true JP6709780B2 (ja) 2020-06-17

Family

ID=55459518

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017513127A Active JP6709780B2 (ja) 2014-09-09 2015-09-09 官能性双性イオン性ポリマーおよび混合電荷ポリマー、関連するヒドロゲルならびにこれらの使用方法
JP2020090650A Pending JP2020139163A (ja) 2014-09-09 2020-05-25 官能性双性イオン性ポリマーおよび混合電荷ポリマー、関連するヒドロゲルならびにこれらの使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020090650A Pending JP2020139163A (ja) 2014-09-09 2020-05-25 官能性双性イオン性ポリマーおよび混合電荷ポリマー、関連するヒドロゲルならびにこれらの使用方法

Country Status (5)

Country Link
US (2) US10272180B2 (https=)
EP (1) EP3191016B1 (https=)
JP (2) JP6709780B2 (https=)
CN (1) CN106999270B (https=)
WO (1) WO2016040489A1 (https=)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808376D0 (en) 2008-05-08 2008-06-18 Bristol Myers Squibb Co Wound dressing
GB0817796D0 (en) 2008-09-29 2008-11-05 Convatec Inc wound dressing
GB201020236D0 (en) 2010-11-30 2011-01-12 Convatec Technologies Inc A composition for detecting biofilms on viable tissues
CN103347562B (zh) 2010-12-08 2016-08-10 康沃特克科技公司 伤口分泌液系统附件
JP5965409B2 (ja) 2010-12-08 2016-08-03 コンバテック・テクノロジーズ・インコーポレイテッドConvatec Technologies Inc 創傷滲出液を評価するための統合システム
PL2648795T3 (pl) 2010-12-08 2023-05-08 Convatec Technologies Inc. System do usuwania wysięków z miejsca rany
GB201115182D0 (en) 2011-09-02 2011-10-19 Trio Healthcare Ltd Skin contact material
GB2497406A (en) 2011-11-29 2013-06-12 Webtec Converting Llc Dressing with a perforated binder layer
ES2690824T3 (es) 2012-07-02 2018-11-22 Boston Scientific Scimed, Inc. Formación de prótesis valvular cardiaca
JP2016507663A (ja) 2012-12-20 2016-03-10 コンバテック・テクノロジーズ・インコーポレイテッドConvatec Technologies Inc 化学修飾セルロース系繊維の加工
EP3191016B1 (en) 2014-09-09 2021-10-27 University of Washington Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methods for their use
US10426609B2 (en) 2015-04-09 2019-10-01 Boston Scientific Scimed, Inc. Fiber reinforced prosthetic heart valve having undulating fibers
US10299915B2 (en) * 2015-04-09 2019-05-28 Boston Scientific Scimed, Inc. Synthetic heart valves composed of zwitterionic polymers
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
US10716671B2 (en) 2015-07-02 2020-07-21 Boston Scientific Scimed, Inc. Prosthetic heart valve composed of composite fibers
US10413403B2 (en) 2015-07-14 2019-09-17 Boston Scientific Scimed, Inc. Prosthetic heart valve including self-reinforced composite leaflets
GB2543544A (en) 2015-10-21 2017-04-26 Brightwake Ltd Wound dressing
WO2017173069A1 (en) 2016-03-30 2017-10-05 Convatec Technologies Inc. Detecting microbial infections in wounds
WO2017212345A2 (en) 2016-03-30 2017-12-14 Synovo Gmbh Detecting microbial infection in wounds
GB201608099D0 (en) 2016-05-09 2016-06-22 Convatec Technologies Inc Negative pressure wound dressing
US10368982B2 (en) 2016-05-19 2019-08-06 Boston Scientific Scimed, Inc. Prosthetic valves, valve leaflets and related methods
JP7071957B2 (ja) 2016-07-08 2022-05-19 コンバテック・テクノロジーズ・インコーポレイテッド 可撓性陰圧システム
BR112019000284A2 (pt) 2016-07-08 2019-04-16 Convatec Technologies Inc. aparelho de coleta de fluido
ES2912094T3 (es) 2016-07-08 2022-05-24 Convatec Technologies Inc Detección de flujo de fluidos
CN109843332A (zh) * 2016-07-22 2019-06-04 华盛顿大学 两性离子微凝胶、其组件和相关制剂及其使用方法
US10995361B2 (en) 2017-01-23 2021-05-04 Massachusetts Institute Of Technology Multiplexed signal amplified FISH via splinted ligation amplification and sequencing
CA3050264A1 (en) * 2017-01-24 2018-08-02 Fred Hutchinson Cancer Research Center Systems and methods for hematopoietic cell expansion utilizing hydrogels
KR102228571B1 (ko) * 2017-02-09 2021-03-16 주식회사 메디폴리머 정신질환 또는 중추신경계 질환 치료용 약물전달 제형
WO2018157074A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for diagnosing neoplastic lesions
WO2018157048A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy
CN110494170A (zh) 2017-04-25 2019-11-22 波士顿科学国际有限公司 生物相容性聚异丁烯-纤维复合材料和方法
JP7208169B2 (ja) * 2017-05-30 2023-01-18 マクマスター ユニバーシティー 新規合成ポリマーおよび架橋ヒドロゲルシステム
EP3658659A1 (en) * 2017-07-24 2020-06-03 Union Carbide Chemicals & Plastics Technology LLC Detergent formulation containing mixed-charge polymers
WO2019022867A1 (en) * 2017-07-24 2019-01-31 Union Carbide Chemicals & Plastics Technology Llc MIXED LOAD POLYMERS
WO2019022866A1 (en) * 2017-07-24 2019-01-31 Union Carbide Chemicals & Plastics Technology Llc COUNTER-IONS MONOMERS AND POLYMERS WITH MIXED LOAD PRODUCTS THEREFROM
AU2018306909A1 (en) * 2017-07-24 2020-02-20 Rohm And Haas Company Chloride-free cationic polymers using acetate anions
AU2018306910A1 (en) * 2017-07-24 2020-02-20 Rohm And Haas Company Chloride-free cationic polymers using acetate anions
US12161792B2 (en) 2017-11-16 2024-12-10 Convatec Limited Fluid collection apparatus
JP7129668B2 (ja) * 2018-01-18 2022-09-02 国立大学法人東海国立大学機構 容器及びその使用
US11873374B2 (en) 2018-02-06 2024-01-16 Massachusetts Institute Of Technology Swellable and structurally homogenous hydrogels and methods of use thereof
JP7359998B2 (ja) * 2018-05-11 2023-10-12 国立大学法人 東京大学 双性イオン基含有ポリマーハイドロゲル
WO2020013833A1 (en) 2018-07-13 2020-01-16 Massachusetts Institute Of Technology Dimethylacrylamide (dmaa) hydrogel for expansion microscopy (exm)
WO2020106338A2 (en) 2018-08-14 2020-05-28 University Of Washington Zwitterionic double network hydrogels
KR102040083B1 (ko) * 2018-09-06 2019-11-05 숭실대학교산학협력단 초분자 구조체 및 그 제조 방법과 자가치유 탄성체
EP3863610A4 (en) * 2018-10-10 2023-03-29 University of Washington High-polymer-density bioconjugate compositions and related methods
CN113454166A (zh) * 2018-12-19 2021-09-28 泰普鲁特医疗技术有限责任公司 基于多糖和两性离子聚合物的水凝胶组合物及其使用方法
US12405193B2 (en) 2019-02-22 2025-09-02 Massachusetts Institute Of Technology Iterative direct expansion microscopy
US12559867B2 (en) 2019-04-30 2026-02-24 Cornell University Fibers of polymers that have a backbone including a positively charged component of a zwitterionic moiety, and their use in implantable therapeutic delivery systems
EP4295869B1 (en) 2019-06-03 2026-01-28 Convatec Limited Devices to disrupt and contain pathogens
CN112587667A (zh) * 2019-09-16 2021-04-02 天津大学 一种长循环的cbma构建的纳米载体及其制备方法
WO2021072281A1 (en) * 2019-10-11 2021-04-15 University Of Washington Modified endonucleases and related methods
CN110698576A (zh) * 2019-10-22 2020-01-17 南京师范大学 一种两性离子聚合物作为大分子pH缓冲材料的应用
US12265004B2 (en) 2019-11-05 2025-04-01 Massachusetts Institute Of Technology Membrane probes for expansion microscopy
US12245935B2 (en) 2019-11-26 2025-03-11 Boston Scientific Limited Composite web-polymer heart valve
WO2021113505A1 (en) 2019-12-05 2021-06-10 Massachusetts Institute Of Technology Method for preparing a specimen for expansion microscopy
US11771819B2 (en) 2019-12-27 2023-10-03 Convatec Limited Low profile filter devices suitable for use in negative pressure wound therapy systems
US11331221B2 (en) 2019-12-27 2022-05-17 Convatec Limited Negative pressure wound dressing
JP2023527796A (ja) * 2020-05-28 2023-06-30 マックマスター、ユニバーシティー インサイチュゲル化両性イオン性ヒドロゲル組成物、及びその使用方法
WO2022071417A1 (ja) 2020-09-29 2022-04-07 キッコーマン株式会社 フラビン依存性乳酸デヒドロゲナーゼを含む組成物の安定性を向上する方法
CN112225829B (zh) * 2020-10-29 2021-08-24 江南大学 一种末端带电荷多糖及其制备方法
CN112760023B (zh) * 2021-01-25 2022-04-26 四川大学 一种混合电荷聚氨酯涂层材料及其制备方法与应用
CN113101412A (zh) * 2021-03-02 2021-07-13 四川大学华西医院 一种长效稳定的抗凝生物瓣膜材料及其制备方法
US20240181404A1 (en) * 2021-04-22 2024-06-06 Trustees Of Tufts College Cross-linked zwitterionic polymer network and their use in membrane filters
CN113476661B (zh) * 2021-07-05 2022-08-05 中国医学科学院生物医学工程研究所 一种三层结构复合型自愈合人造血管及其制备方法
WO2024138098A1 (en) * 2022-12-22 2024-06-27 Trustees Of Tufts College Method for making cross-linkable zwitterionic polymer membranes and their use
WO2024249557A2 (en) * 2023-05-30 2024-12-05 Cornell University Zwitterionic hydrogels for the culture, expansion, and protection of cells and cell-derived products
WO2024254586A1 (en) * 2023-06-09 2024-12-12 Trustees Of Tufts College Zwitterion-containing additive for surface functionalization of silicone materials

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06509889A (ja) * 1992-06-19 1994-11-02 エフ・ホフマン−ラ ロシュ アーゲー 光学的非線形ポリマー
JP3785599B2 (ja) * 1995-02-03 2006-06-14 ノバルティス アクチエンゲゼルシャフト エステル又はアミド基を含む架橋ポリマー
US6150472A (en) * 1995-12-22 2000-11-21 Holland Biomaterials Group B.V. Multi-functional site containing polymers, and applications thereof
US6156478A (en) * 1998-10-30 2000-12-05 3M Innovative Properties Company Photocurable and photopatternable hydrogel matrix based on azlactone copolymers
US20030100830A1 (en) * 2001-11-27 2003-05-29 Sheng-Ping Zhong Implantable or insertable medical devices visible under magnetic resonance imaging
CA2487030A1 (en) * 2002-06-11 2003-12-18 Basf Aktiengesellschaft (meth)acrylic esters of polyalkoxylated glycerine
DE10358372A1 (de) 2003-04-03 2004-10-14 Basf Ag Gemische von Verbindungen mit mindestens zwei Doppelbindungen und deren Verwendung
US20110097277A1 (en) * 2005-08-25 2011-04-28 University Of Washington Particles coated with zwitterionic polymers
JP6085075B2 (ja) * 2005-08-25 2017-02-22 ユニヴァーシティ オブ ワシントン 超低汚損スルホベタインおよびカルボキシベタイン材料ならびに関連する方法
JP2009532383A (ja) * 2006-03-30 2009-09-10 ジェレシス, インク. 胃充填材としてのポリマ材料及びそれらの調製
US7910135B2 (en) * 2006-10-13 2011-03-22 Uluru Inc. Hydrogel wound dressing and biomaterials formed in situ and their uses
EP2099845B1 (en) * 2006-11-27 2020-12-23 Actamax Surgical Materials LLC Multi-functional polyalkylene oxides, hydrogels and tissue adhesives
MX2009007101A (es) * 2006-12-29 2009-12-01 Univ Washington Superficies y materiales antibioincrustación bifuncionales.
US8067028B2 (en) 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
WO2009067565A2 (en) 2007-11-19 2009-05-28 University Of Washington Marine coatings
US8658192B2 (en) * 2007-11-19 2014-02-25 University Of Washington Integrated antimicrobial and low fouling materials
WO2009067566A1 (en) * 2007-11-19 2009-05-28 University Of Washington Hemostatic wound dressings
EP2352522A4 (en) 2008-11-06 2014-03-05 Univ Washington BISPECIFIC AUXILIARIES FOR INTRA-CELLULAR RELEASE
NZ593201A (en) * 2008-12-05 2013-05-31 Semprus Biosciences Corp Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions
CN102317332B (zh) 2008-12-12 2014-04-30 马萨诸塞大学 两性离子聚合物
US8497356B2 (en) 2009-02-17 2013-07-30 Duke University Biomolecule polymer conjugates and methods for making the same
CN102905730A (zh) 2009-11-06 2013-01-30 华盛顿大学商业中心 两性离子聚合物生物缀合物以及相关的方法
WO2011057219A2 (en) 2009-11-06 2011-05-12 University Of Washington Through Its Center For Commercialization Crosslinked zwitterionic hydrogels
CA2799786A1 (en) 2010-06-09 2011-12-15 Semprus Biosciences Corp. Non-fouling, anti-microbial, anti-thrombogenic graft compositions
EP2670757B1 (en) 2011-02-01 2015-05-27 DSM IP Assets B.V. Silicone containing monomers with hydrophilic end groups
EP3191016B1 (en) 2014-09-09 2021-10-27 University of Washington Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methods for their use

Also Published As

Publication number Publication date
CN106999270A (zh) 2017-08-01
EP3191016A4 (en) 2018-06-06
WO2016040489A1 (en) 2016-03-17
US10828398B2 (en) 2020-11-10
US20170266350A1 (en) 2017-09-21
US10272180B2 (en) 2019-04-30
JP2017527669A (ja) 2017-09-21
JP2020139163A (ja) 2020-09-03
EP3191016B1 (en) 2021-10-27
US20200289712A1 (en) 2020-09-17
CN106999270B (zh) 2021-01-01
EP3191016A1 (en) 2017-07-19

Similar Documents

Publication Publication Date Title
JP6709780B2 (ja) 官能性双性イオン性ポリマーおよび混合電荷ポリマー、関連するヒドロゲルならびにこれらの使用方法
JP6400666B2 (ja) 架橋した双性イオンヒドロゲル
US20240123075A1 (en) N-Oxide and Ectoine Monomers, Polymers, Their Compositions, and Related Methods
CN107530295A (zh) 与生物相容性植入物相关的方法和组合物
JP2021533892A (ja) 双性イオン二重ネットワークヒドロゲル
CN107236143A (zh) 阳离子‑两性离子共聚物涂层及其制备方法和应用
US20250375527A1 (en) Immunosuppressive materials and related methods
CN107286355A (zh) 阳离子‑两性离子共聚物与聚己内酯共混膜及其制备方法和应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180830

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180830

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190807

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190807

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20191105

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200203

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200428

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200525

R150 Certificate of patent or registration of utility model

Ref document number: 6709780

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250