CN106999270B - 官能化的两性离子和混合电荷聚合物、相关的水凝胶及它们的使用方法 - Google Patents
官能化的两性离子和混合电荷聚合物、相关的水凝胶及它们的使用方法 Download PDFInfo
- Publication number
- CN106999270B CN106999270B CN201580058874.5A CN201580058874A CN106999270B CN 106999270 B CN106999270 B CN 106999270B CN 201580058874 A CN201580058874 A CN 201580058874A CN 106999270 B CN106999270 B CN 106999270B
- Authority
- CN
- China
- Prior art keywords
- polymer
- hydrogel
- functional group
- zwitterionic
- thiol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0031—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
- C08F220/36—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate
- C08F220/365—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate containing further carboxylic moieties
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
- C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
- C08G81/021—Block or graft polymers containing only sequences of polymers of C08C or C08F
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2539/00—Supports and/or coatings for cell culture characterised by properties
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048155P | 2014-09-09 | 2014-09-09 | |
| US62/048155 | 2014-09-09 | ||
| PCT/US2015/049197 WO2016040489A1 (en) | 2014-09-09 | 2015-09-09 | Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methds for their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106999270A CN106999270A (zh) | 2017-08-01 |
| CN106999270B true CN106999270B (zh) | 2021-01-01 |
Family
ID=55459518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580058874.5A Active CN106999270B (zh) | 2014-09-09 | 2015-09-09 | 官能化的两性离子和混合电荷聚合物、相关的水凝胶及它们的使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10272180B2 (https=) |
| EP (1) | EP3191016B1 (https=) |
| JP (2) | JP6709780B2 (https=) |
| CN (1) | CN106999270B (https=) |
| WO (1) | WO2016040489A1 (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808376D0 (en) | 2008-05-08 | 2008-06-18 | Bristol Myers Squibb Co | Wound dressing |
| GB0817796D0 (en) | 2008-09-29 | 2008-11-05 | Convatec Inc | wound dressing |
| GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
| CN103347562B (zh) | 2010-12-08 | 2016-08-10 | 康沃特克科技公司 | 伤口分泌液系统附件 |
| JP5965409B2 (ja) | 2010-12-08 | 2016-08-03 | コンバテック・テクノロジーズ・インコーポレイテッドConvatec Technologies Inc | 創傷滲出液を評価するための統合システム |
| PL2648795T3 (pl) | 2010-12-08 | 2023-05-08 | Convatec Technologies Inc. | System do usuwania wysięków z miejsca rany |
| GB201115182D0 (en) | 2011-09-02 | 2011-10-19 | Trio Healthcare Ltd | Skin contact material |
| GB2497406A (en) | 2011-11-29 | 2013-06-12 | Webtec Converting Llc | Dressing with a perforated binder layer |
| ES2690824T3 (es) | 2012-07-02 | 2018-11-22 | Boston Scientific Scimed, Inc. | Formación de prótesis valvular cardiaca |
| JP2016507663A (ja) | 2012-12-20 | 2016-03-10 | コンバテック・テクノロジーズ・インコーポレイテッドConvatec Technologies Inc | 化学修飾セルロース系繊維の加工 |
| EP3191016B1 (en) | 2014-09-09 | 2021-10-27 | University of Washington | Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methods for their use |
| US10426609B2 (en) | 2015-04-09 | 2019-10-01 | Boston Scientific Scimed, Inc. | Fiber reinforced prosthetic heart valve having undulating fibers |
| US10299915B2 (en) * | 2015-04-09 | 2019-05-28 | Boston Scientific Scimed, Inc. | Synthetic heart valves composed of zwitterionic polymers |
| US10314696B2 (en) | 2015-04-09 | 2019-06-11 | Boston Scientific Scimed, Inc. | Prosthetic heart valves having fiber reinforced leaflets |
| US10716671B2 (en) | 2015-07-02 | 2020-07-21 | Boston Scientific Scimed, Inc. | Prosthetic heart valve composed of composite fibers |
| US10413403B2 (en) | 2015-07-14 | 2019-09-17 | Boston Scientific Scimed, Inc. | Prosthetic heart valve including self-reinforced composite leaflets |
| GB2543544A (en) | 2015-10-21 | 2017-04-26 | Brightwake Ltd | Wound dressing |
| WO2017173069A1 (en) | 2016-03-30 | 2017-10-05 | Convatec Technologies Inc. | Detecting microbial infections in wounds |
| WO2017212345A2 (en) | 2016-03-30 | 2017-12-14 | Synovo Gmbh | Detecting microbial infection in wounds |
| GB201608099D0 (en) | 2016-05-09 | 2016-06-22 | Convatec Technologies Inc | Negative pressure wound dressing |
| US10368982B2 (en) | 2016-05-19 | 2019-08-06 | Boston Scientific Scimed, Inc. | Prosthetic valves, valve leaflets and related methods |
| JP7071957B2 (ja) | 2016-07-08 | 2022-05-19 | コンバテック・テクノロジーズ・インコーポレイテッド | 可撓性陰圧システム |
| BR112019000284A2 (pt) | 2016-07-08 | 2019-04-16 | Convatec Technologies Inc. | aparelho de coleta de fluido |
| ES2912094T3 (es) | 2016-07-08 | 2022-05-24 | Convatec Technologies Inc | Detección de flujo de fluidos |
| CN109843332A (zh) * | 2016-07-22 | 2019-06-04 | 华盛顿大学 | 两性离子微凝胶、其组件和相关制剂及其使用方法 |
| US10995361B2 (en) | 2017-01-23 | 2021-05-04 | Massachusetts Institute Of Technology | Multiplexed signal amplified FISH via splinted ligation amplification and sequencing |
| CA3050264A1 (en) * | 2017-01-24 | 2018-08-02 | Fred Hutchinson Cancer Research Center | Systems and methods for hematopoietic cell expansion utilizing hydrogels |
| KR102228571B1 (ko) * | 2017-02-09 | 2021-03-16 | 주식회사 메디폴리머 | 정신질환 또는 중추신경계 질환 치료용 약물전달 제형 |
| WO2018157074A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for diagnosing neoplastic lesions |
| WO2018157048A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy |
| CN110494170A (zh) | 2017-04-25 | 2019-11-22 | 波士顿科学国际有限公司 | 生物相容性聚异丁烯-纤维复合材料和方法 |
| JP7208169B2 (ja) * | 2017-05-30 | 2023-01-18 | マクマスター ユニバーシティー | 新規合成ポリマーおよび架橋ヒドロゲルシステム |
| EP3658659A1 (en) * | 2017-07-24 | 2020-06-03 | Union Carbide Chemicals & Plastics Technology LLC | Detergent formulation containing mixed-charge polymers |
| WO2019022867A1 (en) * | 2017-07-24 | 2019-01-31 | Union Carbide Chemicals & Plastics Technology Llc | MIXED LOAD POLYMERS |
| WO2019022866A1 (en) * | 2017-07-24 | 2019-01-31 | Union Carbide Chemicals & Plastics Technology Llc | COUNTER-IONS MONOMERS AND POLYMERS WITH MIXED LOAD PRODUCTS THEREFROM |
| AU2018306909A1 (en) * | 2017-07-24 | 2020-02-20 | Rohm And Haas Company | Chloride-free cationic polymers using acetate anions |
| AU2018306910A1 (en) * | 2017-07-24 | 2020-02-20 | Rohm And Haas Company | Chloride-free cationic polymers using acetate anions |
| US12161792B2 (en) | 2017-11-16 | 2024-12-10 | Convatec Limited | Fluid collection apparatus |
| JP7129668B2 (ja) * | 2018-01-18 | 2022-09-02 | 国立大学法人東海国立大学機構 | 容器及びその使用 |
| US11873374B2 (en) | 2018-02-06 | 2024-01-16 | Massachusetts Institute Of Technology | Swellable and structurally homogenous hydrogels and methods of use thereof |
| JP7359998B2 (ja) * | 2018-05-11 | 2023-10-12 | 国立大学法人 東京大学 | 双性イオン基含有ポリマーハイドロゲル |
| WO2020013833A1 (en) | 2018-07-13 | 2020-01-16 | Massachusetts Institute Of Technology | Dimethylacrylamide (dmaa) hydrogel for expansion microscopy (exm) |
| WO2020106338A2 (en) | 2018-08-14 | 2020-05-28 | University Of Washington | Zwitterionic double network hydrogels |
| KR102040083B1 (ko) * | 2018-09-06 | 2019-11-05 | 숭실대학교산학협력단 | 초분자 구조체 및 그 제조 방법과 자가치유 탄성체 |
| EP3863610A4 (en) * | 2018-10-10 | 2023-03-29 | University of Washington | High-polymer-density bioconjugate compositions and related methods |
| CN113454166A (zh) * | 2018-12-19 | 2021-09-28 | 泰普鲁特医疗技术有限责任公司 | 基于多糖和两性离子聚合物的水凝胶组合物及其使用方法 |
| US12405193B2 (en) | 2019-02-22 | 2025-09-02 | Massachusetts Institute Of Technology | Iterative direct expansion microscopy |
| US12559867B2 (en) | 2019-04-30 | 2026-02-24 | Cornell University | Fibers of polymers that have a backbone including a positively charged component of a zwitterionic moiety, and their use in implantable therapeutic delivery systems |
| EP4295869B1 (en) | 2019-06-03 | 2026-01-28 | Convatec Limited | Devices to disrupt and contain pathogens |
| CN112587667A (zh) * | 2019-09-16 | 2021-04-02 | 天津大学 | 一种长循环的cbma构建的纳米载体及其制备方法 |
| WO2021072281A1 (en) * | 2019-10-11 | 2021-04-15 | University Of Washington | Modified endonucleases and related methods |
| CN110698576A (zh) * | 2019-10-22 | 2020-01-17 | 南京师范大学 | 一种两性离子聚合物作为大分子pH缓冲材料的应用 |
| US12265004B2 (en) | 2019-11-05 | 2025-04-01 | Massachusetts Institute Of Technology | Membrane probes for expansion microscopy |
| US12245935B2 (en) | 2019-11-26 | 2025-03-11 | Boston Scientific Limited | Composite web-polymer heart valve |
| WO2021113505A1 (en) | 2019-12-05 | 2021-06-10 | Massachusetts Institute Of Technology | Method for preparing a specimen for expansion microscopy |
| US11771819B2 (en) | 2019-12-27 | 2023-10-03 | Convatec Limited | Low profile filter devices suitable for use in negative pressure wound therapy systems |
| US11331221B2 (en) | 2019-12-27 | 2022-05-17 | Convatec Limited | Negative pressure wound dressing |
| JP2023527796A (ja) * | 2020-05-28 | 2023-06-30 | マックマスター、ユニバーシティー | インサイチュゲル化両性イオン性ヒドロゲル組成物、及びその使用方法 |
| WO2022071417A1 (ja) | 2020-09-29 | 2022-04-07 | キッコーマン株式会社 | フラビン依存性乳酸デヒドロゲナーゼを含む組成物の安定性を向上する方法 |
| CN112225829B (zh) * | 2020-10-29 | 2021-08-24 | 江南大学 | 一种末端带电荷多糖及其制备方法 |
| CN112760023B (zh) * | 2021-01-25 | 2022-04-26 | 四川大学 | 一种混合电荷聚氨酯涂层材料及其制备方法与应用 |
| CN113101412A (zh) * | 2021-03-02 | 2021-07-13 | 四川大学华西医院 | 一种长效稳定的抗凝生物瓣膜材料及其制备方法 |
| US20240181404A1 (en) * | 2021-04-22 | 2024-06-06 | Trustees Of Tufts College | Cross-linked zwitterionic polymer network and their use in membrane filters |
| CN113476661B (zh) * | 2021-07-05 | 2022-08-05 | 中国医学科学院生物医学工程研究所 | 一种三层结构复合型自愈合人造血管及其制备方法 |
| WO2024138098A1 (en) * | 2022-12-22 | 2024-06-27 | Trustees Of Tufts College | Method for making cross-linkable zwitterionic polymer membranes and their use |
| WO2024249557A2 (en) * | 2023-05-30 | 2024-12-05 | Cornell University | Zwitterionic hydrogels for the culture, expansion, and protection of cells and cell-derived products |
| WO2024254586A1 (en) * | 2023-06-09 | 2024-12-12 | Trustees Of Tufts College | Zwitterion-containing additive for surface functionalization of silicone materials |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101534870A (zh) * | 2006-10-13 | 2009-09-16 | 乌卢鲁公司 | 水凝胶伤口敷料和原位形成的生物材料及其用途 |
| CN101918462A (zh) * | 2007-11-19 | 2010-12-15 | 华盛顿大学 | 具有控制生物性能的两性离子甜菜碱的阳离子甜菜碱前体 |
| US20110097277A1 (en) * | 2005-08-25 | 2011-04-28 | University Of Washington | Particles coated with zwitterionic polymers |
| CN102307955A (zh) * | 2008-12-05 | 2012-01-04 | 森普鲁斯生物科学公司 | 无污、抗菌、抗血栓形成的接出型接枝复合体 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06509889A (ja) * | 1992-06-19 | 1994-11-02 | エフ・ホフマン−ラ ロシュ アーゲー | 光学的非線形ポリマー |
| JP3785599B2 (ja) * | 1995-02-03 | 2006-06-14 | ノバルティス アクチエンゲゼルシャフト | エステル又はアミド基を含む架橋ポリマー |
| US6150472A (en) * | 1995-12-22 | 2000-11-21 | Holland Biomaterials Group B.V. | Multi-functional site containing polymers, and applications thereof |
| US6156478A (en) * | 1998-10-30 | 2000-12-05 | 3M Innovative Properties Company | Photocurable and photopatternable hydrogel matrix based on azlactone copolymers |
| US20030100830A1 (en) * | 2001-11-27 | 2003-05-29 | Sheng-Ping Zhong | Implantable or insertable medical devices visible under magnetic resonance imaging |
| CA2487030A1 (en) * | 2002-06-11 | 2003-12-18 | Basf Aktiengesellschaft | (meth)acrylic esters of polyalkoxylated glycerine |
| DE10358372A1 (de) | 2003-04-03 | 2004-10-14 | Basf Ag | Gemische von Verbindungen mit mindestens zwei Doppelbindungen und deren Verwendung |
| JP6085075B2 (ja) * | 2005-08-25 | 2017-02-22 | ユニヴァーシティ オブ ワシントン | 超低汚損スルホベタインおよびカルボキシベタイン材料ならびに関連する方法 |
| JP2009532383A (ja) * | 2006-03-30 | 2009-09-10 | ジェレシス, インク. | 胃充填材としてのポリマ材料及びそれらの調製 |
| EP2099845B1 (en) * | 2006-11-27 | 2020-12-23 | Actamax Surgical Materials LLC | Multi-functional polyalkylene oxides, hydrogels and tissue adhesives |
| MX2009007101A (es) * | 2006-12-29 | 2009-12-01 | Univ Washington | Superficies y materiales antibioincrustación bifuncionales. |
| US8067028B2 (en) | 2007-08-13 | 2011-11-29 | Confluent Surgical Inc. | Drug delivery device |
| WO2009067565A2 (en) | 2007-11-19 | 2009-05-28 | University Of Washington | Marine coatings |
| US8658192B2 (en) * | 2007-11-19 | 2014-02-25 | University Of Washington | Integrated antimicrobial and low fouling materials |
| EP2352522A4 (en) | 2008-11-06 | 2014-03-05 | Univ Washington | BISPECIFIC AUXILIARIES FOR INTRA-CELLULAR RELEASE |
| CN102317332B (zh) | 2008-12-12 | 2014-04-30 | 马萨诸塞大学 | 两性离子聚合物 |
| US8497356B2 (en) | 2009-02-17 | 2013-07-30 | Duke University | Biomolecule polymer conjugates and methods for making the same |
| CN102905730A (zh) | 2009-11-06 | 2013-01-30 | 华盛顿大学商业中心 | 两性离子聚合物生物缀合物以及相关的方法 |
| WO2011057219A2 (en) | 2009-11-06 | 2011-05-12 | University Of Washington Through Its Center For Commercialization | Crosslinked zwitterionic hydrogels |
| CA2799786A1 (en) | 2010-06-09 | 2011-12-15 | Semprus Biosciences Corp. | Non-fouling, anti-microbial, anti-thrombogenic graft compositions |
| EP2670757B1 (en) | 2011-02-01 | 2015-05-27 | DSM IP Assets B.V. | Silicone containing monomers with hydrophilic end groups |
| EP3191016B1 (en) | 2014-09-09 | 2021-10-27 | University of Washington | Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methods for their use |
-
2015
- 2015-09-09 EP EP15840077.0A patent/EP3191016B1/en active Active
- 2015-09-09 US US15/509,607 patent/US10272180B2/en active Active
- 2015-09-09 CN CN201580058874.5A patent/CN106999270B/zh active Active
- 2015-09-09 JP JP2017513127A patent/JP6709780B2/ja active Active
- 2015-09-09 WO PCT/US2015/049197 patent/WO2016040489A1/en not_active Ceased
-
2019
- 2019-04-29 US US16/398,002 patent/US10828398B2/en active Active
-
2020
- 2020-05-25 JP JP2020090650A patent/JP2020139163A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110097277A1 (en) * | 2005-08-25 | 2011-04-28 | University Of Washington | Particles coated with zwitterionic polymers |
| CN101534870A (zh) * | 2006-10-13 | 2009-09-16 | 乌卢鲁公司 | 水凝胶伤口敷料和原位形成的生物材料及其用途 |
| CN101918462A (zh) * | 2007-11-19 | 2010-12-15 | 华盛顿大学 | 具有控制生物性能的两性离子甜菜碱的阳离子甜菜碱前体 |
| CN102307955A (zh) * | 2008-12-05 | 2012-01-04 | 森普鲁斯生物科学公司 | 无污、抗菌、抗血栓形成的接出型接枝复合体 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106999270A (zh) | 2017-08-01 |
| EP3191016A4 (en) | 2018-06-06 |
| WO2016040489A1 (en) | 2016-03-17 |
| US10828398B2 (en) | 2020-11-10 |
| US20170266350A1 (en) | 2017-09-21 |
| US10272180B2 (en) | 2019-04-30 |
| JP2017527669A (ja) | 2017-09-21 |
| JP2020139163A (ja) | 2020-09-03 |
| JP6709780B2 (ja) | 2020-06-17 |
| EP3191016B1 (en) | 2021-10-27 |
| US20200289712A1 (en) | 2020-09-17 |
| EP3191016A1 (en) | 2017-07-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106999270B (zh) | 官能化的两性离子和混合电荷聚合物、相关的水凝胶及它们的使用方法 | |
| JP6400666B2 (ja) | 架橋した双性イオンヒドロゲル | |
| US20240123075A1 (en) | N-Oxide and Ectoine Monomers, Polymers, Their Compositions, and Related Methods | |
| CN107530295A (zh) | 与生物相容性植入物相关的方法和组合物 | |
| JP2021533892A (ja) | 双性イオン二重ネットワークヒドロゲル | |
| US20250375527A1 (en) | Immunosuppressive materials and related methods | |
| AU2007301693B2 (en) | Polymer | |
| CN109705359B (zh) | 一种改性聚乙二醇-聚癸二酸(pegs)可注射生物弹性体及其制备方法和应用 | |
| CN111423571B (zh) | 一种生物可降解两性离子聚碳酸酯及其应用 | |
| WO2023013410A1 (ja) | 高分子組成物 | |
| Wang | Functional Self-healing Hydrogels Based on Dynamic Molecular Interactions for Biomedical Applications | |
| JP2012029835A (ja) | 表面コーティング剤、及び医療用具 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |