JP6708635B2 - ＣＤ３εおよびＲＯＲ１に対する二特異性抗体 - Google Patents

ＣＤ３εおよびＲＯＲ１に対する二特異性抗体 Download PDF

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JP6708635B2
JP6708635B2 JP2017518525A JP2017518525A JP6708635B2 JP 6708635 B2 JP6708635 B2 JP 6708635B2 JP 2017518525 A JP2017518525 A JP 2017518525A JP 2017518525 A JP2017518525 A JP 2017518525A JP 6708635 B2 JP6708635 B2 JP 6708635B2
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ror1
antibody
cells
fab
cell
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JP2018502050A5 (enExample
JP2018502050A (ja
Inventor
ミン ディエム ヴー，
ミン ディエム ヴー，
クラウス シュトライン，
クラウス シュトライン，
オリヴァー アスト，
オリヴァー アスト，
ターニャ ファウティ，
ターニャ ファウティ，
アンネ フライモーザー−グルントショーバー，
アンネ フライモーザー−グルントショーバー，
ラルフ ホッセ，
ラルフ ホッセ，
クリスティアン クライン，
クリスティアン クライン，
エッケハルト メスナー，
エッケハルト メスナー，
サミュエル モーザー，
サミュエル モーザー，
ラモーナ ムル，
ラモーナ ムル，
パブロ ウマーナ，
パブロ ウマーナ，
ザビーネ ジュン−イムホーフ，
ザビーネ ジュン−イムホーフ，
シュテファン クロスターマン，
シュテファン クロスターマン，
ミカエル モルホイ，
ミカエル モルホイ，
イェルク レギュラ，
イェルク レギュラ，
ヴォルフガング シェーファー，
ヴォルフガング シェーファー，
Original Assignee
エンクマフ エスアーエールエル
エンクマフ エスアーエールエル
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017518525A 2014-10-09 2015-10-08 ＣＤ３εおよびＲＯＲ１に対する二特異性抗体 Expired - Fee Related JP6708635B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14188378.5 2014-10-09
EP14188378 2014-10-09
EP14188727 2014-10-14
EP14188727.3 2014-10-14
PCT/EP2015/073308 WO2016055592A1 (en) 2014-10-09 2015-10-08 Bispecific antibodies against cd3epsilon and ror1

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JP2018502050A JP2018502050A (ja) 2018-01-25
JP2018502050A5 JP2018502050A5 (enExample) 2019-04-04
JP6708635B2 true JP6708635B2 (ja) 2020-06-10

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US (1) US11952421B2 (enExample)
EP (1) EP3204415B1 (enExample)
JP (1) JP6708635B2 (enExample)
AU (1) AU2015329965A1 (enExample)
CA (1) CA2963692A1 (enExample)
ES (1) ES2850325T3 (enExample)
WO (1) WO2016055592A1 (enExample)

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