JP6698708B2 - 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体 - Google Patents

分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体 Download PDF

Info

Publication number
JP6698708B2
JP6698708B2 JP2017564364A JP2017564364A JP6698708B2 JP 6698708 B2 JP6698708 B2 JP 6698708B2 JP 2017564364 A JP2017564364 A JP 2017564364A JP 2017564364 A JP2017564364 A JP 2017564364A JP 6698708 B2 JP6698708 B2 JP 6698708B2
Authority
JP
Japan
Prior art keywords
sequence
tag
tagged
polynucleotides
polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017564364A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018522543A (ja
JP2018522543A5 (cg-RX-API-DMAC7.html
Inventor
アン モンガン
アン モンガン
リチャード チェン
リチャード チェン
ドゥミトル ブリンザ
ドゥミトル ブリンザ
ケリー ブラムレット
ケリー ブラムレット
Original Assignee
ライフ テクノロジーズ コーポレーション
ライフ テクノロジーズ コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライフ テクノロジーズ コーポレーション, ライフ テクノロジーズ コーポレーション filed Critical ライフ テクノロジーズ コーポレーション
Publication of JP2018522543A publication Critical patent/JP2018522543A/ja
Publication of JP2018522543A5 publication Critical patent/JP2018522543A5/ja
Application granted granted Critical
Publication of JP6698708B2 publication Critical patent/JP6698708B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
JP2017564364A 2015-06-09 2016-06-09 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体 Active JP6698708B2 (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201562172836P 2015-06-09 2015-06-09
US62/172,836 2015-06-09
US201562207177P 2015-08-19 2015-08-19
US62/207,177 2015-08-19
US201562248978P 2015-10-30 2015-10-30
US62/248,978 2015-10-30
US201662304530P 2016-03-07 2016-03-07
US62/304,530 2016-03-07
US201662310647P 2016-03-18 2016-03-18
US62/310,647 2016-03-18
US201662311276P 2016-03-21 2016-03-21
US62/311,276 2016-03-21
US201662323142P 2016-04-15 2016-04-15
US62/323,142 2016-04-15
PCT/US2016/036763 WO2016201142A1 (en) 2015-06-09 2016-06-09 Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging

Publications (3)

Publication Number Publication Date
JP2018522543A JP2018522543A (ja) 2018-08-16
JP2018522543A5 JP2018522543A5 (cg-RX-API-DMAC7.html) 2019-07-04
JP6698708B2 true JP6698708B2 (ja) 2020-05-27

Family

ID=56292898

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017564364A Active JP6698708B2 (ja) 2015-06-09 2016-06-09 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体

Country Status (5)

Country Link
US (3) US10344336B2 (cg-RX-API-DMAC7.html)
EP (2) EP3653728B1 (cg-RX-API-DMAC7.html)
JP (1) JP6698708B2 (cg-RX-API-DMAC7.html)
CN (1) CN107849600A (cg-RX-API-DMAC7.html)
WO (1) WO2016201142A1 (cg-RX-API-DMAC7.html)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170009288A1 (en) * 2014-02-03 2017-01-12 Thermo Fisher Scientific Baltics Uab Method for controlled dna fragmentation
US11136576B2 (en) * 2014-02-03 2021-10-05 Thermo Fisher Scientific Baltics Uab Method for controlled DNA fragmentation
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
WO2016201142A1 (en) 2015-06-09 2016-12-15 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
CN109072294A (zh) 2015-12-08 2018-12-21 特温斯特兰德生物科学有限公司 用于双重测序的改良衔接子、方法和组合物
KR20220151011A (ko) 2016-09-23 2022-11-11 알베오 테크놀로지스 인크. 분석물을 검출하기 위한 방법 및 조성물
CA3038661C (en) 2016-09-27 2025-05-06 Psomagen, Inc. METHOD AND SYSTEM FOR PREPARING AND SEQUENCING CRISPR-BASED BANK
EP3529400B1 (en) 2016-10-24 2021-02-17 Geneinfosec, Inc. Concealing information present within nucleic acids
EP3692161A4 (en) 2016-11-11 2022-05-25 Psomagen, Inc. METHODS AND SYSTEM FOR FRAGMENT ARRANGEMENT AND SEQUENCE IDENTIFICATION
US11352662B2 (en) 2017-01-20 2022-06-07 Sequenom, Inc. Sequence adapter manufacture and use
CN110914911B (zh) 2017-05-16 2023-09-22 生命科技股份有限公司 压缩分子标记的核酸序列数据的方法
US12209274B2 (en) * 2017-05-31 2025-01-28 Centrillion Technology Holdings Corporation Oligonucleotide probe array with electronic detection system
US11542540B2 (en) 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
WO2018236631A1 (en) * 2017-06-20 2018-12-27 Illumina, Inc. METHODS AND COMPOSITIONS FOR RESOLVING INEFFICIENCY IN AMPLIFICATION REACTIONS
CN111315895A (zh) * 2017-09-14 2020-06-19 豪夫迈·罗氏有限公司 用于产生环状单链dna文库的新型方法
US11894105B2 (en) 2017-09-20 2024-02-06 Life Technologies Corporation Methods for detection of fusions using compressed molecular tagged nucleic acid
CA3090134A1 (en) * 2018-02-02 2019-08-08 Apdn (B.V.I.) Inc. Systems and methods for tracking the origin of cannabis products and cannabis derivative products
GB201804642D0 (en) 2018-03-22 2018-05-09 Inivata Ltd Methods of labelling nucleic acids
GB201804641D0 (en) * 2018-03-22 2018-05-09 Inivata Ltd Methods of sequencing nucleic acids and error correction of sequence reads
CN112236520B (zh) 2018-04-02 2025-01-24 格里尔公司 甲基化标记和标靶甲基化探针板
CN108486230B (zh) * 2018-05-18 2022-02-08 中国人民解放军陆军军医大学第一附属医院 用于无创检测mitf基因突变的试剂盒及其制备方法
CN108959851B (zh) * 2018-06-12 2022-03-18 哈尔滨工程大学 一种Illumina高通量测序数据误差校正方法
CN112292460A (zh) 2018-06-12 2021-01-29 主基因有限公司 核酸扩增方法
AU2019319711B2 (en) 2018-08-08 2025-08-28 Inivata Ltd. Method of sequencing using variable replicate multiplex PCR
EP3837380A4 (en) * 2018-08-17 2022-05-11 Cellecta, Inc. MULTIPLEX PREPARATION OF BARCODE GENE-SPECIFIC DNA FRAGMENTS
JP2021535739A (ja) 2018-08-27 2021-12-23 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 下流精製でのラマン分光法の使用
CA3111887A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
AU2019392932B2 (en) * 2018-12-07 2023-11-02 Element Biosciences, Inc. Flow cell device and use thereof
CN112654715B (zh) * 2018-12-19 2024-12-31 亿明达股份有限公司 改进多核苷酸簇克隆性优先性的方法
MX2021007297A (es) 2018-12-20 2021-09-08 Alveo Tech Inc Sistema portatil de prueba de diagnostico basado en impedancias para detectar analitos.
JP2022516441A (ja) * 2018-12-20 2022-02-28 アルヴェオ テクノロジーズ インコーポレイテッド 電気的検出を伴う等温増幅
EP3942557A1 (en) 2019-03-22 2022-01-26 Life Technologies Corporation Methods for partner agnostic gene fusion detection
EP3748013A1 (en) * 2019-06-04 2020-12-09 Sysmex Corporation Method for analyzing a nucleic acid sequence
EP3748015A1 (en) 2019-06-04 2020-12-09 Sysmex Corporation Method for analyzing nucleic acid sequence, apparatus for analyzing nucleic acid sequence, and program for analyzing nucleic acid sequence
EP3748014A1 (en) 2019-06-04 2020-12-09 Sysmex Corporation Method for analyzing nucleic acid sequence, apparatus for analyzing nucleic acid sequence, and program for analyzing nucleic acid sequence
CN114514328A (zh) * 2019-08-21 2022-05-17 生命技术公司 用于测序的系统和方法
EP4022092A1 (en) * 2019-08-30 2022-07-06 Life Technologies Corporation Compositions and methods for oncology precision assays
EP4085063A4 (en) * 2019-12-30 2023-09-06 Yuandian Biolabs Co., Ltd. METHOD FOR PREPARING NUCLEIC ACID SEQUENCES USING AN ENZYME
CA3167729A1 (en) 2020-01-13 2021-07-22 Fluent Biosciences Inc. Emulsion based drug screening
EP4090466A4 (en) 2020-01-13 2024-01-17 Fluent Biosciences Inc. Methods and systems for single cell gene profiling
CN115698282A (zh) 2020-01-13 2023-02-03 福路伦特生物科学公司 单细胞测序
US20210214769A1 (en) * 2020-01-13 2021-07-15 Fluent Biosciences Inc. Methods and systems for amplifying low concentrations of nucleic acids
CN111254198A (zh) * 2020-03-09 2020-06-09 苏州宏元生物科技有限公司 一种尿路上皮癌诊断和预后评估试剂盒
WO2021188500A1 (en) 2020-03-16 2021-09-23 Fluent Biosciences Inc. Multi-omic analysis in monodisperse droplets
EP4127058A4 (en) 2020-03-24 2024-04-24 Fluent Biosciences Inc. VIRAL DETECTION USING MATRIX EMULSIFICATION
CN111466508A (zh) * 2020-04-10 2020-07-31 四川长虹电器股份有限公司 射频解冻装置、冰箱及射频解冻方法
US20240279736A1 (en) 2020-06-18 2024-08-22 Resolve Biosciences Gmbh Multiplex method for detecting different analytes and different subgroups/variations of an analyte in a sample
JP2023534028A (ja) 2020-07-15 2023-08-07 フルーエント バイオサイエンシーズ インコーポレイテッド 段階的ライゲーション用オリゴ
US12472492B2 (en) 2020-08-14 2025-11-18 Alveo Technologies, Inc. Systems and methods of sample depositing and testing
US11959074B2 (en) 2020-11-14 2024-04-16 Life Technologies Corporation System and method for automated repeat sequencing
US11220707B1 (en) 2021-06-17 2022-01-11 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
US11859241B2 (en) 2021-06-17 2024-01-02 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
AU2024201404B2 (en) * 2023-03-01 2025-11-27 Personal Genomics Taiwan, Inc. Method, kit and cartridge for detecting nucleic acid molecule
WO2024196764A2 (en) * 2023-03-17 2024-09-26 Nanostring Technologies, Inc. Assay for recombinase accessible chromatin and related compositions and methods
WO2025085618A1 (en) * 2023-10-20 2025-04-24 Illumina, Inc. Methods for appending adaptors onto polynucleotides

Family Cites Families (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5223414A (en) 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
US5273881A (en) 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
DE69220084T2 (de) 1990-05-07 1997-09-11 Daikin Ind Ltd Diagnostische Anwendungen der Bildung von doppelten D-Loops.
US5194370A (en) 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5882856A (en) 1995-06-07 1999-03-16 Genzyme Corporation Universal primer sequence for multiplex DNA amplification
US6444806B1 (en) 1996-04-30 2002-09-03 Hisamitsu Pharmaceutical Co., Inc. Conjugates and methods of forming conjugates of oligonucleotides and carbohydrates
WO1998044151A1 (en) 1997-04-01 1998-10-08 Glaxo Group Limited Method of nucleic acid amplification
EP1019496B1 (en) 1997-07-07 2004-09-29 Medical Research Council In vitro sorting method
FI103809B1 (fi) 1997-07-14 1999-09-30 Finnzymes Oy In vitro -menetelmä templaattien tuottamiseksi DNA-sekventointia varten
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
WO2000015779A2 (en) 1998-09-15 2000-03-23 Yale University Molecular cloning using rolling circle amplification
US6287825B1 (en) 1998-09-18 2001-09-11 Molecular Staging Inc. Methods for reducing the complexity of DNA sequences
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
US6830884B1 (en) 1998-12-15 2004-12-14 Molecular Staging Inc. Method of amplification
US6521428B1 (en) 1999-04-21 2003-02-18 Genome Technologies, Llc Shot-gun sequencing and amplification without cloning
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
AU2001238068A1 (en) 2000-02-07 2001-08-14 Illumina, Inc. Nucleic acid detection methods using universal priming
EP1337541B1 (en) 2000-10-06 2007-03-07 The Trustees of Columbia University in the City of New York Massive parallel method for decoding DNA and RNA
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
AU2002222737A1 (en) 2001-12-08 2003-06-23 Seegene, Inc Annealing control primer system for regulating primer annealing specificity and its applications
US20030175749A1 (en) 2001-12-08 2003-09-18 Jong-Yoon Chun Annealing control primer and its uses
EP1319718A1 (en) 2001-12-14 2003-06-18 Keygene N.V. High throughput analysis and detection of multiple target sequences
PT1499738E (pt) 2002-02-21 2008-10-20 Asm Scient Inc Amplificação de polimerase recombinase
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
GB0208768D0 (en) 2002-04-17 2002-05-29 Univ Newcastle DNA polymerases
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
US20040038331A1 (en) 2002-08-23 2004-02-26 Reddy M. Parameswara Solid phase synthesis of biomolecule conjugates
US7541444B2 (en) 2002-08-23 2009-06-02 Illumina Cambridge Limited Modified nucleotides
CN102212614B (zh) 2003-01-29 2013-12-25 454生命科学公司 核酸扩增和测序的方法
WO2005071110A2 (en) 2004-01-23 2005-08-04 Lingvitae As Improving polynucleotide ligation reactions
EP2230315A1 (en) 2005-02-01 2010-09-22 AB Advanced Genetic Analysis Corporation Nucleic acid sequencing by performing successive cycles of duplex extension
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
DE602006015633D1 (de) 2005-04-29 2010-09-02 Synthetic Genomics Inc Amplifikation und klonierung einzelner dna-moleküle mittels rolling-circle-amplifikation
US20060263789A1 (en) 2005-05-19 2006-11-23 Robert Kincaid Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using
JP5220597B2 (ja) 2005-06-23 2013-06-26 キージーン ナムローゼ フェンノートシャップ １つ又は複数の多型性を同定する方法およびその使用方法
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
EP2829615B1 (en) 2005-07-25 2018-05-09 Alere San Diego, Inc. Kit for multiplexing recombinase polymerase amplification
US20070031857A1 (en) 2005-08-02 2007-02-08 Rubicon Genomics, Inc. Compositions and methods for processing and amplification of DNA, including using multiple enzymes in a single reaction
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
ATE453728T1 (de) 2005-09-29 2010-01-15 Keygene Nv Screening mutagenisierter populationen mit hohem durchsatz
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
WO2007087312A2 (en) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
WO2007111937A1 (en) 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
US8071308B2 (en) 2006-05-04 2011-12-06 Alere San Diego, Inc. Recombinase polymerase amplification
US8644588B2 (en) 2006-09-20 2014-02-04 Luminescent Technologies, Inc. Photo-mask and wafer image reconstruction
WO2008042067A2 (en) 2006-09-28 2008-04-10 Illumina, Inc. Compositions and methods for nucleotide sequencing
WO2008069973A2 (en) 2006-12-01 2008-06-12 The Trustees Of Columbia University In The City Of New York Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
EP4134667B1 (en) 2006-12-14 2025-11-12 Life Technologies Corporation Apparatus for measuring analytes using fet arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US7932034B2 (en) 2006-12-20 2011-04-26 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH measurement for sequencing of DNA
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
AU2008239495A1 (en) 2007-02-27 2008-10-23 Northwestern University Molecule attachment to nanoparticles
AU2008307617B2 (en) 2007-09-28 2013-05-23 Pacific Biosciences Of California, Inc. Error-free amplification of DNA for clonal sequencing
WO2009120372A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
US8271206B2 (en) * 2008-04-21 2012-09-18 Softgenetics Llc DNA sequence assembly methods of short reads
US8029993B2 (en) 2008-04-30 2011-10-04 Population Genetics Technologies Ltd. Asymmetric adapter library construction
GB2461127B (en) 2008-06-25 2010-07-14 Ion Torrent Systems Inc Methods and apparatus for measuring analytes using large scale FET arrays
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9080211B2 (en) 2008-10-24 2015-07-14 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
US9394567B2 (en) * 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
EP2358875B1 (en) 2008-11-19 2015-08-12 Amyris, Inc. Compositions and methods for the assembly of polynucleotides
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
EP2438196B1 (en) 2009-06-05 2016-12-21 Alere San Diego, Inc. Recombinase polymerase amplification reagents and kits
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
EP2606343A4 (en) 2010-08-18 2017-08-16 Life Technologies Corporation Chemical coating of microwell for electrochemical detection device
JP5992911B2 (ja) 2010-09-21 2016-09-14 ポピュレーション ジェネティクス テクノロジーズ リミテッド 分子計数による対立遺伝子呼び出しの信頼度の増加
EP3141614B1 (en) 2010-10-27 2018-11-28 Life Technologies Corporation Predictive model for use in sequencing-by-synthesis
EP2652148B1 (en) 2010-12-17 2016-11-30 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
EP3225697A3 (en) 2010-12-30 2017-11-22 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
US20130090860A1 (en) 2010-12-30 2013-04-11 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
ES2568910T3 (es) 2011-01-28 2016-05-05 Illumina, Inc. Reemplazo de oligonucleótidos para bibliotecas etiquetadas en dos extremos y direccionadas
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
JP5961247B2 (ja) 2011-04-07 2016-08-02 アリーア サン ディエゴ， インコーポレイテッド リコンビナーゼポリメラーゼ増幅混合物のモニタリング
US9617296B2 (en) 2011-04-08 2017-04-11 Life Technologies Corporation Methods and kits for breaking emulsions
EP2697397B1 (en) 2011-04-15 2017-04-05 The Johns Hopkins University Safe sequencing system
US9809904B2 (en) * 2011-04-21 2017-11-07 University Of Washington Through Its Center For Commercialization Methods for retrieval of sequence-verified DNA constructs
WO2012166647A1 (en) 2011-05-27 2012-12-06 Life Technologies Corporation Methods for manipulating biomolecules
US20130017978A1 (en) 2011-07-11 2013-01-17 Finnzymes Oy Methods and transposon nucleic acids for generating a dna library
US9145623B2 (en) 2011-07-20 2015-09-29 Thermo Fisher Scientific Oy Transposon nucleic acids comprising a calibration sequence for DNA sequencing
EP2820158B1 (en) * 2012-02-27 2018-01-10 Cellular Research, Inc. Compositions and kits for molecular counting
WO2013130512A2 (en) * 2012-02-27 2013-09-06 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
CA2867293C (en) * 2012-03-13 2020-09-01 Abhijit Ajit PATEL Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
PL2828218T3 (pl) 2012-03-20 2021-01-11 University Of Washington Through Its Center For Commercialization Sposoby obniżania współczynnika błędów masywnie równoległej sekwencji dna z wykorzystaniem duplex consensus sequencing
CA2872141C (en) 2012-05-31 2016-01-19 Board Of Regents, The University Of Texas System Method for accurate sequencing of dna
JP2015521472A (ja) 2012-06-14 2015-07-30 フレッド ハチンソン キャンサー リサーチ センター 核酸分子における高感度変異検出のための組成物および方法
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
WO2014026031A1 (en) 2012-08-10 2014-02-13 Sequenta, Inc. High sensitivity mutation detection using sequence tags
US20140066317A1 (en) * 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
KR102393608B1 (ko) 2012-09-04 2022-05-03 가던트 헬쓰, 인크. 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법
CN103045726B (zh) * 2012-11-20 2015-11-25 南方科技大学 对多个混合dna或rna序列进行基因测序的方法及装置
WO2014093330A1 (en) 2012-12-10 2014-06-19 Clearfork Bioscience, Inc. Methods for targeted genomic analysis
US20160186267A1 (en) * 2013-02-21 2016-06-30 Toma Biosciences, Inc. Methods, compositions, and kits for nucleic acid analysis
US20140255929A1 (en) * 2013-03-11 2014-09-11 Sequenta, Inc. Mosaic tags for labeling templates in large-scale amplifications
US10066260B2 (en) 2013-03-14 2018-09-04 Life Technologies Corporation Matrix arrays and methods for making same
ITMI20130496A1 (it) 2013-03-29 2014-09-30 Atlas Copco Blm Srl Gruppo e disposizione di montaggio di una spina di un connettore circolare a baionetta su un pannello o una parete, in particolare un pannello o una parete di un corpo scatolare di contenimento di un dispositivo elettrico o elettronico
US20140357499A1 (en) * 2013-05-30 2014-12-04 Washington University METHODS OF LOW ERROR AMPLICON SEQUENCING (LEA-Seq) AND THE USE THEREOF
WO2015031559A1 (en) 2013-08-30 2015-03-05 Tensor Surgical, Inc Passive retrieving interosseous suture passing device
GB2518668B (en) 2013-09-28 2017-07-12 Design Blue Ltd Flexible pads and shield systems
US9476853B2 (en) 2013-12-10 2016-10-25 Life Technologies Corporation System and method for forming microwells
SG11201604923XA (en) 2013-12-28 2016-07-28 Guardant Health Inc Methods and systems for detecting genetic variants
HK1225758A1 (zh) 2014-01-16 2017-09-15 Illumina, Inc. 固体支持物上的扩增子制备和测序
US20170009288A1 (en) 2014-02-03 2017-01-12 Thermo Fisher Scientific Baltics Uab Method for controlled dna fragmentation
US10809225B2 (en) 2014-07-02 2020-10-20 Life Technologies Corporation Surface treatment of semiconductor sensors
WO2016010856A1 (en) 2014-07-15 2016-01-21 Qiagen Sciences, Llc Semi-random barcodes for nucleic acid analysis
WO2016201142A1 (en) 2015-06-09 2016-12-15 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging

Also Published As

Publication number Publication date
US12338496B2 (en) 2025-06-24
EP3307908B1 (en) 2019-09-11
CN107849600A (zh) 2018-03-27
US11124842B2 (en) 2021-09-21
US10344336B2 (en) 2019-07-09
EP3307908A1 (en) 2018-04-18
EP3653728A1 (en) 2020-05-20
WO2016201142A1 (en) 2016-12-15
EP3653728B1 (en) 2023-02-01
US20190323091A1 (en) 2019-10-24
JP2018522543A (ja) 2018-08-16
US20160362748A1 (en) 2016-12-15
US20210363596A1 (en) 2021-11-25

Similar Documents

Publication Publication Date Title
JP6698708B2 (ja) 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体
US11725241B2 (en) Compositions and methods for identification of a duplicate sequencing read
EP3377625B1 (en) Method for controlled dna fragmentation
US10072283B2 (en) Direct capture, amplification and sequencing of target DNA using immobilized primers
KR102709499B1 (ko) 단일 세포 전체 게놈 라이브러리 및 이의 제조를 위한 조합 인덱싱 방법
CN109689888B (zh) 无细胞核酸标准品及其用途
EP3715468A1 (en) Methods and compositions for preparing sequencing libraries
EP4180539A1 (en) Single end duplex dna sequencing
US11136576B2 (en) Method for controlled DNA fragmentation
EP4267763B1 (en) Compositions and methods for highly sensitive detection of target sequences in multiplex reactions
CN114450420A (zh) 用于肿瘤学精确测定的组合物和方法
HK40027672B (zh) 用於甲基化测序的单细胞全基因组文库

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171225

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190603

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190603

TRDD Decision of grant or rejection written
A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200325

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200330

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200428

R150 Certificate of patent or registration of utility model

Ref document number: 6698708

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250