JP6687520B2 - 極めて長い相補性決定領域を有するヒト化抗体 - Google Patents

極めて長い相補性決定領域を有するヒト化抗体 Download PDF

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JP6687520B2
JP6687520B2 JP2016527148A JP2016527148A JP6687520B2 JP 6687520 B2 JP6687520 B2 JP 6687520B2 JP 2016527148 A JP2016527148 A JP 2016527148A JP 2016527148 A JP2016527148 A JP 2016527148A JP 6687520 B2 JP6687520 B2 JP 6687520B2
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sequence
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antibody
amino acid
variable region
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JP2016527234A (ja
JP2016527234A5 (https=
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オマー バジルガン
オマー バジルガン
ロス リオス ミゲル デ
ロス リオス ミゲル デ
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トーラス バイオサイエンシズ リミテッド ライアビリティ カンパニー
トーラス バイオサイエンシズ リミテッド ライアビリティ カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2016527148A 2013-07-18 2014-07-18 極めて長い相補性決定領域を有するヒト化抗体 Active JP6687520B2 (ja)

Applications Claiming Priority (3)

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US201361856010P 2013-07-18 2013-07-18
US61/856,010 2013-07-18
PCT/US2014/047315 WO2015010100A2 (en) 2013-07-18 2014-07-18 Humanized antibodies with ultralong complementarity determining regions

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JP2016527234A JP2016527234A (ja) 2016-09-08
JP2016527234A5 JP2016527234A5 (https=) 2017-08-31
JP6687520B2 true JP6687520B2 (ja) 2020-04-22

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JP2016527148A Active JP6687520B2 (ja) 2013-07-18 2014-07-18 極めて長い相補性決定領域を有するヒト化抗体
JP2020066669A Pending JP2020114245A (ja) 2013-07-18 2020-04-02 極めて長い相補性決定領域を有するヒト化抗体
JP2023001446A Active JP7680480B2 (ja) 2013-07-18 2023-01-10 極めて長い相補性決定領域を有するヒト化抗体

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JP2023001446A Active JP7680480B2 (ja) 2013-07-18 2023-01-10 極めて長い相補性決定領域を有するヒト化抗体

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US (3) US10640574B2 (https=)
EP (1) EP3022221B1 (https=)
JP (3) JP6687520B2 (https=)
CN (2) CN111518199A (https=)
AU (1) AU2014290361B2 (https=)
CA (1) CA2918370A1 (https=)
WO (1) WO2015010100A2 (https=)

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KR102888509B1 (ko) * 2016-01-08 2025-11-20 맥시온 테라퓨틱스 리미티드 변형된 다양성 스캐폴드 도메인을 갖는 결합 멤버
BR112019024556A2 (pt) 2017-05-24 2020-06-23 Novartis Ag Proteínas enxertadas com citocina de anticorpo e métodos para uso no tratamento de câncer
JOP20190271A1 (ar) 2017-05-24 2019-11-21 Novartis Ag بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة
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WO2021081440A2 (en) * 2019-10-24 2021-04-29 Minotaur Therapeutics, Inc. Chimeric cytokine modified antibodies and methods of use thereof
BR112022019047A2 (pt) * 2020-03-27 2022-11-01 UCB Biopharma SRL Peptídeos de domínio knob autônomos
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WO2023192478A1 (en) 2022-04-01 2023-10-05 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
CN120129934A (zh) 2022-10-24 2025-06-10 软银集团股份有限公司 信息处理装置、信息处理方法以及信息处理程序
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