JP6678656B2 - 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用 - Google Patents

新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用 Download PDF

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Publication number
JP6678656B2
JP6678656B2 JP2017515074A JP2017515074A JP6678656B2 JP 6678656 B2 JP6678656 B2 JP 6678656B2 JP 2017515074 A JP2017515074 A JP 2017515074A JP 2017515074 A JP2017515074 A JP 2017515074A JP 6678656 B2 JP6678656 B2 JP 6678656B2
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Prior art keywords
mmol
piperidin
pyridin
piperidine
stirred
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Japanese (ja)
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JP2017527602A5 (enExample
JP2017527602A (ja
Inventor
アン、マリー、ジャンヌ、ブーイヨ
ネリナ、ドディク
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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Priority to JP2020035272A priority Critical patent/JP6908747B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
JP2017515074A 2014-09-19 2015-09-18 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用 Active JP6678656B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020035272A JP6908747B2 (ja) 2014-09-19 2020-03-02 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462052537P 2014-09-19 2014-09-19
US62/052,537 2014-09-19
PCT/IB2015/057219 WO2016042536A1 (en) 2014-09-19 2015-09-18 Novel soluble guanylate cyclase activators and their use

Related Child Applications (1)

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JP2020035272A Division JP6908747B2 (ja) 2014-09-19 2020-03-02 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用

Publications (3)

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JP2017527602A JP2017527602A (ja) 2017-09-21
JP2017527602A5 JP2017527602A5 (enExample) 2018-10-25
JP6678656B2 true JP6678656B2 (ja) 2020-04-08

Family

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JP2017515074A Active JP6678656B2 (ja) 2014-09-19 2015-09-18 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用
JP2020035272A Active JP6908747B2 (ja) 2014-09-19 2020-03-02 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用
JP2021109106A Pending JP2021155450A (ja) 2014-09-19 2021-06-30 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用

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JP2020035272A Active JP6908747B2 (ja) 2014-09-19 2020-03-02 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用
JP2021109106A Pending JP2021155450A (ja) 2014-09-19 2021-06-30 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用

Country Status (21)

Country Link
US (2) US9938260B2 (enExample)
EP (1) EP3194384A1 (enExample)
JP (3) JP6678656B2 (enExample)
KR (1) KR20170054508A (enExample)
CN (1) CN106687456B (enExample)
AU (1) AU2015319724B2 (enExample)
BR (1) BR112017005660A2 (enExample)
CA (1) CA2961745A1 (enExample)
CL (1) CL2017000640A1 (enExample)
CO (1) CO2017002506A2 (enExample)
CR (1) CR20170102A (enExample)
DO (1) DOP2017000073A (enExample)
EA (1) EA033697B1 (enExample)
IL (1) IL251094A0 (enExample)
MA (1) MA40583A (enExample)
MX (1) MX2017003621A (enExample)
PE (1) PE20170937A1 (enExample)
PH (1) PH12017500481A1 (enExample)
SG (1) SG11201701915TA (enExample)
WO (1) WO2016042536A1 (enExample)
ZA (1) ZA201701835B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020105189A (ja) * 2014-09-19 2020-07-09 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2685230C2 (ru) 2014-02-06 2019-04-17 Хептарес Терапьютикс Лимитед Бициклические азотсодержащие соединения как агонисты М1 мускариновых рецепторов
WO2016042084A1 (en) 2014-09-19 2016-03-24 Bayer Pharma Aktiengesellschaft Benzyl substituted indazoles as bub1 inhibitors
US11331308B2 (en) 2016-10-11 2022-05-17 Bayer Pharma Aktiengesellschaft Combination containing sGC activators and mineralocorticoid receptor antagonists
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
EP3498298A1 (en) 2017-12-15 2019-06-19 Bayer AG The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi)
CN112055584A (zh) 2018-04-30 2020-12-08 拜耳公司 sGC活化剂和sGC刺激剂用于治疗认知障碍的用途
MA52616A (fr) 2018-05-15 2021-03-24 Bayer Ag Benzamides à substitution 1,3-thiazol-2-yl pour le traitement de maladies associées à la sensibilisation de fibres nerveuses
US11508483B2 (en) 2018-05-30 2022-11-22 Adverio Pharma Gmbh Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group
WO2020148379A1 (en) 2019-01-17 2020-07-23 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
CN119300815A (zh) 2022-06-09 2025-01-10 拜耳公司 用于治疗女性射血分数保留型心力衰竭的可溶性鸟苷酸环化酶激活剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602143A (en) 1994-12-08 1997-02-11 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors
JP5411703B2 (ja) * 2006-11-09 2014-02-12 アルコン リサーチ， リミテッド 薬物送達のための水不溶性ポリマーマトリクス
PE20091258A1 (es) * 2007-12-03 2009-09-12 Smithkline Beecham Corp Derivados de piridina como activadores de la guanilato ciclasa soluble
WO2010015653A1 (en) * 2008-08-07 2010-02-11 Smithkline Beecham Corporation Pyrimidine derivatives as activators of soluble guanylate cyclase
CA2753434C (en) 2009-02-26 2014-07-15 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
DE102009012314A1 (de) 2009-03-09 2010-09-16 Bayer Schering Pharma Aktiengesellschaft Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung
JP5636296B2 (ja) 2011-01-20 2014-12-03 公益財団法人微生物化学研究会 塩分含有有機廃液処理剤、並びに、塩分濃度低下剤、塩分含有有機廃液の処理方法、及び包括固定担体
EA033697B1 (ru) * 2014-09-19 2019-11-18 Glaxosmithkline Ip Dev Ltd Активаторы растворимой гуанилатциклазы и их применение

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020105189A (ja) * 2014-09-19 2020-07-09 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用
JP2021155450A (ja) * 2014-09-19 2021-10-07 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 新規な可溶性グアニル酸シクラーゼ活性剤およびそれらの使用

Also Published As

Publication number Publication date
JP2020105189A (ja) 2020-07-09
CN106687456B (zh) 2019-12-03
AU2015319724B2 (en) 2018-05-10
US20170305888A1 (en) 2017-10-26
MA40583A (fr) 2016-03-24
ZA201701835B (en) 2018-12-19
DOP2017000073A (es) 2017-04-16
EA033697B1 (ru) 2019-11-18
MX2017003621A (es) 2017-07-14
JP2017527602A (ja) 2017-09-21
KR20170054508A (ko) 2017-05-17
WO2016042536A1 (en) 2016-03-24
US9938260B2 (en) 2018-04-10
PE20170937A1 (es) 2017-07-13
CA2961745A1 (en) 2016-03-24
CL2017000640A1 (es) 2017-10-06
BR112017005660A2 (pt) 2017-12-19
JP6908747B2 (ja) 2021-07-28
SG11201701915TA (en) 2017-04-27
IL251094A0 (en) 2017-04-30
US10472350B2 (en) 2019-11-12
CO2017002506A2 (es) 2017-07-28
EP3194384A1 (en) 2017-07-26
CR20170102A (es) 2017-07-17
US20180194756A1 (en) 2018-07-12
JP2021155450A (ja) 2021-10-07
EA201790655A1 (ru) 2017-08-31
AU2015319724A1 (en) 2017-04-06
CN106687456A (zh) 2017-05-17
PH12017500481A1 (en) 2017-08-07

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