AU2015319724B2 - Novel soluble guanylate cyclase activators and their use - Google Patents
Novel soluble guanylate cyclase activators and their use Download PDFInfo
- Publication number
- AU2015319724B2 AU2015319724B2 AU2015319724A AU2015319724A AU2015319724B2 AU 2015319724 B2 AU2015319724 B2 AU 2015319724B2 AU 2015319724 A AU2015319724 A AU 2015319724A AU 2015319724 A AU2015319724 A AU 2015319724A AU 2015319724 B2 AU2015319724 B2 AU 2015319724B2
- Authority
- AU
- Australia
- Prior art keywords
- pyridin
- piperidine
- piperidin
- carboxylic acid
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- JMUMPWSPSXRGHQ-QXMHVHEDSA-N CCCCC(/C=C\C(COc(c(-c1cccc(N(CC2)CCC2C(O)=O)n1)cc(F)c1)c1F)=C(C)C)=C Chemical compound CCCCC(/C=C\C(COc(c(-c1cccc(N(CC2)CCC2C(O)=O)n1)cc(F)c1)c1F)=C(C)C)=C JMUMPWSPSXRGHQ-QXMHVHEDSA-N 0.000 description 1
- QFSBUAQLGFRKMU-UHFFFAOYSA-N CCOC(C(CC1)CCN1c1cccc(-c(cccc2Cl)c2OCc(cc2)c(C)cc2C(CC2)=CCN2C(OC(C)(C)C)=O)n1)=O Chemical compound CCOC(C(CC1)CCN1c1cccc(-c(cccc2Cl)c2OCc(cc2)c(C)cc2C(CC2)=CCN2C(OC(C)(C)C)=O)n1)=O QFSBUAQLGFRKMU-UHFFFAOYSA-N 0.000 description 1
- IXMUJGKAKDOWGG-UHFFFAOYSA-N CCOC(C(CC1)CCN1c1cccc(-c2cc(F)cc(F)c2OCc2c(C)nc(C(CC3)CCN3C3COC3)cc2)n1)=O Chemical compound CCOC(C(CC1)CCN1c1cccc(-c2cc(F)cc(F)c2OCc2c(C)nc(C(CC3)CCN3C3COC3)cc2)n1)=O IXMUJGKAKDOWGG-UHFFFAOYSA-N 0.000 description 1
- MYIXSULJWVDQDL-UHFFFAOYSA-N CCOC(C(CC1)CCN1c1nc(-c(cc(cc2F)F)c2OCc2c(C)cc(C(CC3)CCN3C(C3COCC3)=O)cc2)ccc1)=O Chemical compound CCOC(C(CC1)CCN1c1nc(-c(cc(cc2F)F)c2OCc2c(C)cc(C(CC3)CCN3C(C3COCC3)=O)cc2)ccc1)=O MYIXSULJWVDQDL-UHFFFAOYSA-N 0.000 description 1
- RLEVLGVJEXGCKI-UHFFFAOYSA-N CCOC(C(CC1)CCN1c1nc(-c2cccc(Cl)c2OCc2c(C)cc(C(CC3)CCN3C(OC(C)(C)C)=O)cc2)ccc1)=O Chemical compound CCOC(C(CC1)CCN1c1nc(-c2cccc(Cl)c2OCc2c(C)cc(C(CC3)CCN3C(OC(C)(C)C)=O)cc2)ccc1)=O RLEVLGVJEXGCKI-UHFFFAOYSA-N 0.000 description 1
- HCDNKIGTODLOHQ-UHFFFAOYSA-N Cc1c(COc(c(-c2cccc(N(CC3)CCC3C(O)=O)n2)cc(F)c2)c2F)ccc(C(CC2)CCN2C(CC2CC2)=O)c1 Chemical compound Cc1c(COc(c(-c2cccc(N(CC3)CCC3C(O)=O)n2)cc(F)c2)c2F)ccc(C(CC2)CCN2C(CC2CC2)=O)c1 HCDNKIGTODLOHQ-UHFFFAOYSA-N 0.000 description 1
- PYENYACKOYCDJH-MHZLTWQESA-N Cc1c(COc(c(-c2cccc(N(CC3)CCC3C(O)=O)n2)cc(F)c2)c2F)ccc(C(CC2)CCN2C([C@@H]2COCC2)=O)c1 Chemical compound Cc1c(COc(c(-c2cccc(N(CC3)CCC3C(O)=O)n2)cc(F)c2)c2F)ccc(C(CC2)CCN2C([C@@H]2COCC2)=O)c1 PYENYACKOYCDJH-MHZLTWQESA-N 0.000 description 1
- WMLHMVDBWUFYJZ-UHFFFAOYSA-N Cc1c(COc(c(-c2cccc(N(CC3)CCC3C(O)=O)n2)cc(F)c2)c2F)ccc(C(CC2)CCN2C2COCC2)c1 Chemical compound Cc1c(COc(c(-c2cccc(N(CC3)CCC3C(O)=O)n2)cc(F)c2)c2F)ccc(C(CC2)CCN2C2COCC2)c1 WMLHMVDBWUFYJZ-UHFFFAOYSA-N 0.000 description 1
- DNKWTZKVEYQVGW-UHFFFAOYSA-N Cc1c(COc(c(F)cc(F)c2)c2-c2cccc(N(CC3)CCC3C(O)=O)n2)ccc(C(CC2)CCN2C(C2COC2)=C)n1 Chemical compound Cc1c(COc(c(F)cc(F)c2)c2-c2cccc(N(CC3)CCC3C(O)=O)n2)ccc(C(CC2)CCN2C(C2COC2)=C)n1 DNKWTZKVEYQVGW-UHFFFAOYSA-N 0.000 description 1
- WABDLYLYJYZPMM-UHFFFAOYSA-N Cc1c(COc(c(F)cc(F)c2)c2-c2cccc(N(CC3)CCC3C(O)=O)n2)ccc(C(CC2)CCN2C(CC2COCC2)=O)c1 Chemical compound Cc1c(COc(c(F)cc(F)c2)c2-c2cccc(N(CC3)CCC3C(O)=O)n2)ccc(C(CC2)CCN2C(CC2COCC2)=O)c1 WABDLYLYJYZPMM-UHFFFAOYSA-N 0.000 description 1
- WZBFPIKJFWYRFY-UHFFFAOYSA-N Cc1c(COc(c(F)cc(F)c2)c2-c2cccc(N(CC3)CCC3C(O)=O)n2)ccc(C2CCN(CCO)CC2)c1 Chemical compound Cc1c(COc(c(F)cc(F)c2)c2-c2cccc(N(CC3)CCC3C(O)=O)n2)ccc(C2CCN(CCO)CC2)c1 WZBFPIKJFWYRFY-UHFFFAOYSA-N 0.000 description 1
- DSKILVZVICTKIE-UHFFFAOYSA-N Cc1cc(OC2CCN(CC(F)(F)F)CC2)ccc1COc(c(F)cc(F)c1)c1-c1cccc(N(CC2)CCC2C(O)=O)n1 Chemical compound Cc1cc(OC2CCN(CC(F)(F)F)CC2)ccc1COc(c(F)cc(F)c1)c1-c1cccc(N(CC2)CCC2C(O)=O)n1 DSKILVZVICTKIE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462052537P | 2014-09-19 | 2014-09-19 | |
| US62/052,537 | 2014-09-19 | ||
| PCT/IB2015/057219 WO2016042536A1 (en) | 2014-09-19 | 2015-09-18 | Novel soluble guanylate cyclase activators and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015319724A1 AU2015319724A1 (en) | 2017-04-06 |
| AU2015319724B2 true AU2015319724B2 (en) | 2018-05-10 |
Family
ID=54238488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015319724A Active AU2015319724B2 (en) | 2014-09-19 | 2015-09-18 | Novel soluble guanylate cyclase activators and their use |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9938260B2 (enExample) |
| EP (1) | EP3194384A1 (enExample) |
| JP (3) | JP6678656B2 (enExample) |
| KR (1) | KR20170054508A (enExample) |
| CN (1) | CN106687456B (enExample) |
| AU (1) | AU2015319724B2 (enExample) |
| BR (1) | BR112017005660A2 (enExample) |
| CA (1) | CA2961745A1 (enExample) |
| CL (1) | CL2017000640A1 (enExample) |
| CO (1) | CO2017002506A2 (enExample) |
| CR (1) | CR20170102A (enExample) |
| DO (1) | DOP2017000073A (enExample) |
| EA (1) | EA033697B1 (enExample) |
| IL (1) | IL251094A0 (enExample) |
| MA (1) | MA40583A (enExample) |
| MX (1) | MX2017003621A (enExample) |
| PE (1) | PE20170937A1 (enExample) |
| PH (1) | PH12017500481A1 (enExample) |
| SG (1) | SG11201701915TA (enExample) |
| WO (1) | WO2016042536A1 (enExample) |
| ZA (1) | ZA201701835B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2685230C2 (ru) | 2014-02-06 | 2019-04-17 | Хептарес Терапьютикс Лимитед | Бициклические азотсодержащие соединения как агонисты М1 мускариновых рецепторов |
| EA033697B1 (ru) * | 2014-09-19 | 2019-11-18 | Glaxosmithkline Ip Dev Ltd | Активаторы растворимой гуанилатциклазы и их применение |
| WO2016042084A1 (en) | 2014-09-19 | 2016-03-24 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles as bub1 inhibitors |
| US11331308B2 (en) | 2016-10-11 | 2022-05-17 | Bayer Pharma Aktiengesellschaft | Combination containing sGC activators and mineralocorticoid receptor antagonists |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
| CN112055584A (zh) | 2018-04-30 | 2020-12-08 | 拜耳公司 | sGC活化剂和sGC刺激剂用于治疗认知障碍的用途 |
| MA52616A (fr) | 2018-05-15 | 2021-03-24 | Bayer Ag | Benzamides à substitution 1,3-thiazol-2-yl pour le traitement de maladies associées à la sensibilisation de fibres nerveuses |
| US11508483B2 (en) | 2018-05-30 | 2022-11-22 | Adverio Pharma Gmbh | Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group |
| WO2020148379A1 (en) | 2019-01-17 | 2020-07-23 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc) |
| CN119300815A (zh) | 2022-06-09 | 2025-01-10 | 拜耳公司 | 用于治疗女性射血分数保留型心力衰竭的可溶性鸟苷酸环化酶激活剂 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009071504A1 (en) * | 2007-12-03 | 2009-06-11 | Smithkline Beecham Corporation | 2,6-disubstituted pyridines as soluble guanylate cyclase activators |
| WO2010015653A1 (en) * | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Pyrimidine derivatives as activators of soluble guanylate cyclase |
| WO2010099054A2 (en) * | 2009-02-26 | 2010-09-02 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602143A (en) | 1994-12-08 | 1997-02-11 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors |
| JP5411703B2 (ja) * | 2006-11-09 | 2014-02-12 | アルコン リサーチ， リミテッド | 薬物送達のための水不溶性ポリマーマトリクス |
| DE102009012314A1 (de) | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
| JP5636296B2 (ja) | 2011-01-20 | 2014-12-03 | 公益財団法人微生物化学研究会 | 塩分含有有機廃液処理剤、並びに、塩分濃度低下剤、塩分含有有機廃液の処理方法、及び包括固定担体 |
| EA033697B1 (ru) * | 2014-09-19 | 2019-11-18 | Glaxosmithkline Ip Dev Ltd | Активаторы растворимой гуанилатциклазы и их применение |
-
2015
- 2015-09-18 EA EA201790655A patent/EA033697B1/ru not_active IP Right Cessation
- 2015-09-18 KR KR1020177010181A patent/KR20170054508A/ko not_active Ceased
- 2015-09-18 CN CN201580050717.XA patent/CN106687456B/zh active Active
- 2015-09-18 BR BR112017005660A patent/BR112017005660A2/pt not_active Application Discontinuation
- 2015-09-18 AU AU2015319724A patent/AU2015319724B2/en active Active
- 2015-09-18 JP JP2017515074A patent/JP6678656B2/ja active Active
- 2015-09-18 CR CR20170102A patent/CR20170102A/es unknown
- 2015-09-18 MA MA040583A patent/MA40583A/fr unknown
- 2015-09-18 MX MX2017003621A patent/MX2017003621A/es unknown
- 2015-09-18 US US15/509,895 patent/US9938260B2/en active Active
- 2015-09-18 SG SG11201701915TA patent/SG11201701915TA/en unknown
- 2015-09-18 CA CA2961745A patent/CA2961745A1/en not_active Abandoned
- 2015-09-18 WO PCT/IB2015/057219 patent/WO2016042536A1/en not_active Ceased
- 2015-09-18 PE PE2017000478A patent/PE20170937A1/es unknown
- 2015-09-18 EP EP15772026.9A patent/EP3194384A1/en not_active Withdrawn
-
2017
- 2017-03-12 IL IL251094A patent/IL251094A0/en unknown
- 2017-03-14 PH PH12017500481A patent/PH12017500481A1/en unknown
- 2017-03-14 ZA ZA2017/01835A patent/ZA201701835B/en unknown
- 2017-03-16 CO CONC2017/0002506A patent/CO2017002506A2/es unknown
- 2017-03-16 CL CL2017000640A patent/CL2017000640A1/es unknown
- 2017-03-16 DO DO2017000073A patent/DOP2017000073A/es unknown
-
2018
- 2018-03-05 US US15/911,797 patent/US10472350B2/en active Active
-
2020
- 2020-03-02 JP JP2020035272A patent/JP6908747B2/ja active Active
-
2021
- 2021-06-30 JP JP2021109106A patent/JP2021155450A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009071504A1 (en) * | 2007-12-03 | 2009-06-11 | Smithkline Beecham Corporation | 2,6-disubstituted pyridines as soluble guanylate cyclase activators |
| WO2010015653A1 (en) * | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Pyrimidine derivatives as activators of soluble guanylate cyclase |
| WO2010099054A2 (en) * | 2009-02-26 | 2010-09-02 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020105189A (ja) | 2020-07-09 |
| CN106687456B (zh) | 2019-12-03 |
| US20170305888A1 (en) | 2017-10-26 |
| MA40583A (fr) | 2016-03-24 |
| ZA201701835B (en) | 2018-12-19 |
| DOP2017000073A (es) | 2017-04-16 |
| JP6678656B2 (ja) | 2020-04-08 |
| EA033697B1 (ru) | 2019-11-18 |
| MX2017003621A (es) | 2017-07-14 |
| JP2017527602A (ja) | 2017-09-21 |
| KR20170054508A (ko) | 2017-05-17 |
| WO2016042536A1 (en) | 2016-03-24 |
| US9938260B2 (en) | 2018-04-10 |
| PE20170937A1 (es) | 2017-07-13 |
| CA2961745A1 (en) | 2016-03-24 |
| CL2017000640A1 (es) | 2017-10-06 |
| BR112017005660A2 (pt) | 2017-12-19 |
| JP6908747B2 (ja) | 2021-07-28 |
| SG11201701915TA (en) | 2017-04-27 |
| IL251094A0 (en) | 2017-04-30 |
| US10472350B2 (en) | 2019-11-12 |
| CO2017002506A2 (es) | 2017-07-28 |
| EP3194384A1 (en) | 2017-07-26 |
| CR20170102A (es) | 2017-07-17 |
| US20180194756A1 (en) | 2018-07-12 |
| JP2021155450A (ja) | 2021-10-07 |
| EA201790655A1 (ru) | 2017-08-31 |
| AU2015319724A1 (en) | 2017-04-06 |
| CN106687456A (zh) | 2017-05-17 |
| PH12017500481A1 (en) | 2017-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |