JP6671292B2 - ペプチド模倣化合物及びその抗体−薬物コンジュゲート - Google Patents

ペプチド模倣化合物及びその抗体−薬物コンジュゲート Download PDF

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JP6671292B2
JP6671292B2 JP2016558549A JP2016558549A JP6671292B2 JP 6671292 B2 JP6671292 B2 JP 6671292B2 JP 2016558549 A JP2016558549 A JP 2016558549A JP 2016558549 A JP2016558549 A JP 2016558549A JP 6671292 B2 JP6671292 B2 JP 6671292B2
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antibody
amino acid
acid sequence
seq
alkylene
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JP2017503011A5 (OSRAM
JP2017503011A (ja
Inventor
ジョン フライゲア，
ジョン フライゲア，
ジャネット ガンズナー−トースト，
ジャネット ガンズナー−トースト，
トーマス ピロー，
トーマス ピロー，
ブライアン サフィーナ，
ブライアン サフィーナ，
ヴィシャル ヴァーマ，
ヴィシャル ヴァーマ，
ビンチン ウェイ，
ビンチン ウェイ，
コイリン チャオ，
コイリン チャオ，
レアンナ スターバン，
レアンナ スターバン，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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JP2016558549A 2013-12-16 2014-12-16 ペプチド模倣化合物及びその抗体−薬物コンジュゲート Active JP6671292B2 (ja)

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US201361916680P 2013-12-16 2013-12-16
US61/916,680 2013-12-16
PCT/US2014/070654 WO2015095223A2 (en) 2013-12-16 2014-12-16 Peptidomimetic compounds and antibody-drug conjugates thereof

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JP2017503011A JP2017503011A (ja) 2017-01-26
JP2017503011A5 JP2017503011A5 (OSRAM) 2018-02-01
JP6671292B2 true JP6671292B2 (ja) 2020-03-25

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US (1) US9999681B2 (OSRAM)
EP (1) EP3082874A2 (OSRAM)
JP (1) JP6671292B2 (OSRAM)
KR (1) KR102354207B1 (OSRAM)
CN (1) CN105873614B (OSRAM)
BR (1) BR112016012410A2 (OSRAM)
CA (1) CA2928952A1 (OSRAM)
MX (1) MX371092B (OSRAM)
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WO2015095227A2 (en) * 2013-12-16 2015-06-25 Genentech, Inc. Peptidomimetic compounds and antibody-drug conjugates thereof
HK1222577A1 (zh) 2013-12-16 2017-07-07 Genentech Inc. 擬肽化合物及其抗體藥物偶聯物
EA201790569A1 (ru) 2014-09-12 2017-08-31 Дженентек, Инк. Антитела и иммуноконъюгаты против cll-1
BR112017003236A2 (pt) 2014-09-12 2017-11-28 Genentech Inc anticorpos elaborados com cisteína, conjugados de droga e anticorpos, método de preparação de conjugado de droga e anticorpo e composição farmacêutica
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EP3082874A2 (en) 2016-10-26
RU2689388C1 (ru) 2019-05-28
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