JP6665193B2 - Ｎｅｐ阻害剤を調製するための方法および中間体 - Google Patents

Ｎｅｐ阻害剤を調製するための方法および中間体 Download PDF

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JP6665193B2
JP6665193B2 JP2017542062A JP2017542062A JP6665193B2 JP 6665193 B2 JP6665193 B2 JP 6665193B2 JP 2017542062 A JP2017542062 A JP 2017542062A JP 2017542062 A JP2017542062 A JP 2017542062A JP 6665193 B2 JP6665193 B2 JP 6665193B2
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JP2018506541A5 (enExample
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マーティン，ベンジャミン
マンドレリ，フランセスカ
ヴェントゥロニ，フランセスコ
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ノバルティス アーゲー
ノバルティス アーゲー
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    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/10—Preparation of nitro compounds by substitution of functional groups by nitro groups
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    • B01J31/0237—Amines
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    • B01J31/0255—Phosphorus containing compounds
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    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
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    • C07C205/53—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/28—Phosphorus compounds with one or more P—C bonds
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017542062A 2015-02-13 2016-02-11 Ｎｅｐ阻害剤を調製するための方法および中間体 Active JP6665193B2 (ja)

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EP15155147 2015-02-13
EP15155147.0 2015-02-13
PCT/IB2016/050725 WO2016128924A1 (en) 2015-02-13 2016-02-11 Process and intermediates for the preparation of nep inhibitors

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JP2018506541A5 JP2018506541A5 (enExample) 2019-08-29
JP6665193B2 true JP6665193B2 (ja) 2020-03-13

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US (1) US10385004B2 (enExample)
EP (1) EP3256444B1 (enExample)
JP (1) JP6665193B2 (enExample)
CN (1) CN107250100B (enExample)
TW (1) TW201632493A (enExample)
WO (1) WO2016128924A1 (enExample)

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Publication number Priority date Publication date Assignee Title
EP3500549B1 (en) * 2016-08-17 2020-12-16 Novartis AG New processes and intermediates for nep inhibitor synthesis
AU2017371353B2 (en) * 2016-12-09 2022-02-03 Celltaxis, Llc Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase
CN109053800B (zh) * 2018-07-30 2020-08-14 湖北大学 季鏻盐支载手性氨基-硫脲及其制备方法和用途
CN113121342B (zh) * 2019-12-31 2022-05-31 浙江医药股份有限公司新昌制药厂 一种沙库必曲中间体的制备方法及应用
CN114957043B (zh) * 2022-04-29 2023-09-08 凯特立斯（深圳）科技有限公司 沙库必曲中间体、其制备方法及其应用
CN117902945A (zh) * 2023-12-22 2024-04-19 香港科技大学深圳研究院 手性α-氯代羰基化合物的制备方法

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JPS5439029A (en) * 1977-09-01 1979-03-24 Sagami Chem Res Center Nitro compounds
US5217996A (en) 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
EP1903027A1 (en) * 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
MY151993A (en) 2007-01-12 2014-07-31 Novartis Ag Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
PE20091364A1 (es) 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
CN101774941A (zh) 2009-01-13 2010-07-14 浙江九洲药业股份有限公司 2-酰基氨基-3-联苯基丙酸的制备及拆分方法
MX2011012628A (es) * 2009-05-28 2011-12-14 Novartis Ag Derivados amino-propionicos sustituidos como inhibidores de neprilisina.
KR20120093227A (ko) 2009-09-23 2012-08-22 노파르티스 아게 Ｎ-아실비페닐 알라닌의 제조 방법
AU2011207020B2 (en) 2010-01-22 2014-04-17 Novartis Ag Intermediates of neutral endopeptidase inhibitors and preparation method thereof
EP2609075B1 (en) 2010-08-23 2016-03-16 Novartis AG Process for the preparation of intermediates for the manufacture of nep inhibitors
KR20130106374A (ko) 2010-08-23 2013-09-27 노파르티스 아게 Ｎｅｐ 억제제의 제조에 유용한 중간체의 신규한 제조 방법
AR092278A1 (es) 2012-08-31 2015-04-08 Novartis Ag Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados
GB201219300D0 (en) 2012-10-26 2012-12-12 Isis Innovation Bifunctional organic catalysts
WO2015189862A1 (en) * 2014-06-10 2015-12-17 Council Of Scientific & Industrial Research Chiral amines, a process for preparation and use thereof

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WO2016128924A1 (en) 2016-08-18
US10385004B2 (en) 2019-08-20
CN107250100B (zh) 2019-12-06
US20180022690A1 (en) 2018-01-25
TW201632493A (zh) 2016-09-16
CN107250100A (zh) 2017-10-13
EP3256444A1 (en) 2017-12-20
EP3256444B1 (en) 2019-03-27
JP2018506541A (ja) 2018-03-08

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