JP6649358B2 - アンジオポエチン様４抗体および使用法 - Google Patents

アンジオポエチン様４抗体および使用法 Download PDF

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Publication number
JP6649358B2
JP6649358B2 JP2017506693A JP2017506693A JP6649358B2 JP 6649358 B2 JP6649358 B2 JP 6649358B2 JP 2017506693 A JP2017506693 A JP 2017506693A JP 2017506693 A JP2017506693 A JP 2017506693A JP 6649358 B2 JP6649358 B2 JP 6649358B2
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antibody
seq
angptl4
antibodies
sequence
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JP2017529324A5 (enExample
JP2017529324A (ja
Inventor
トラウガー，ジョン
イゴレビッチ ボズネセンスキ，アンドレイ
イゴレビッチ ボズネセンスキ，アンドレイ
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ノバルティス アーゲー
ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017506693A 2014-08-07 2015-08-06 アンジオポエチン様４抗体および使用法 Active JP6649358B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462034409P 2014-08-07 2014-08-07
US62/034,409 2014-08-07
PCT/IB2015/055986 WO2016020880A2 (en) 2014-08-07 2015-08-06 Angiopoietin-like 4 antibodies and methods of use

Related Child Applications (1)

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JP2020004261A Division JP2020075929A (ja) 2014-08-07 2020-01-15 アンジオポエチン様４抗体および使用法

Publications (3)

Publication Number Publication Date
JP2017529324A JP2017529324A (ja) 2017-10-05
JP2017529324A5 JP2017529324A5 (enExample) 2018-09-06
JP6649358B2 true JP6649358B2 (ja) 2020-02-19

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Family Applications (4)

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JP2017506693A Active JP6649358B2 (ja) 2014-08-07 2015-08-06 アンジオポエチン様４抗体および使用法
JP2020004261A Pending JP2020075929A (ja) 2014-08-07 2020-01-15 アンジオポエチン様４抗体および使用法
JP2022007104A Active JP7397104B2 (ja) 2014-08-07 2022-01-20 アンジオポエチン様４抗体および使用法
JP2023202489A Active JP7695330B2 (ja) 2014-08-07 2023-11-30 アンジオポエチン様４抗体および使用法

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JP2020004261A Pending JP2020075929A (ja) 2014-08-07 2020-01-15 アンジオポエチン様４抗体および使用法
JP2022007104A Active JP7397104B2 (ja) 2014-08-07 2022-01-20 アンジオポエチン様４抗体および使用法
JP2023202489A Active JP7695330B2 (ja) 2014-08-07 2023-11-30 アンジオポエチン様４抗体および使用法

Country Status (31)

Country Link
US (5) US9771417B2 (enExample)
EP (2) EP3177642B1 (enExample)
JP (4) JP6649358B2 (enExample)
KR (2) KR102659872B1 (enExample)
CN (1) CN107148428B (enExample)
AP (1) AP2017009721A0 (enExample)
AR (1) AR101486A1 (enExample)
AU (1) AU2015300685B2 (enExample)
BR (1) BR112017002173B1 (enExample)
CL (1) CL2017000212A1 (enExample)
CO (1) CO2017001087A2 (enExample)
CR (1) CR20170040A (enExample)
CU (1) CU24453B1 (enExample)
DK (1) DK3177642T3 (enExample)
EA (1) EA201790336A1 (enExample)
EC (1) ECSP17013904A (enExample)
ES (1) ES2906216T3 (enExample)
IL (1) IL250289B2 (enExample)
JO (1) JO3565B1 (enExample)
MA (1) MA40512A (enExample)
MX (2) MX390418B (enExample)
NZ (1) NZ728425A (enExample)
PE (1) PE20170287A1 (enExample)
PH (1) PH12017500156A1 (enExample)
PL (1) PL3177642T3 (enExample)
PT (1) PT3177642T (enExample)
SG (2) SG10201805646WA (enExample)
TN (1) TN2017000019A1 (enExample)
TW (1) TWI675043B (enExample)
UY (1) UY36262A (enExample)
WO (1) WO2016020880A2 (enExample)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
WO2016020880A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
WO2016020882A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
GB2569144B (en) * 2017-12-06 2021-06-16 Proimmune Ltd Method for screening the activity of mutated expressed polypeptides
EP3746477A1 (en) * 2018-02-02 2020-12-09 Bio-Techne Corporation Compounds that modulate the interaction of vista and vsig3 and methods of making and using
KR20210143858A (ko) * 2019-03-26 2021-11-29 얀센 파마슈티카 엔.브이. 피로글루타메이트 아밀로이드-β에 대한 항체 및 이의 용도
EP4493590A1 (en) * 2022-03-16 2025-01-22 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to treat infectious diseases
US11780910B1 (en) * 2022-05-02 2023-10-10 Novo Nordisk A/S Anti-ANGPTL3 antibodies suitable for high concentration compositions and subcutaneous administration
WO2025166073A1 (en) * 2024-01-31 2025-08-07 Alector Llc Compositions comprising anti-sortilin antibodies and uses thereof

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