JP6639411B2 - 放射性医薬品化合物の製造のためのイオン性液体担持有機スズ試薬 - Google Patents

放射性医薬品化合物の製造のためのイオン性液体担持有機スズ試薬 Download PDF

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JP6639411B2
JP6639411B2 JP2016562070A JP2016562070A JP6639411B2 JP 6639411 B2 JP6639411 B2 JP 6639411B2 JP 2016562070 A JP2016562070 A JP 2016562070A JP 2016562070 A JP2016562070 A JP 2016562070A JP 6639411 B2 JP6639411 B2 JP 6639411B2
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aryl
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JP2017504658A (ja
JP2017504658A5 (https=
Inventor
レゴウピー，ステファニ
ファイユ，ジブリル
ゲスチン，ジャン−フランソワ
ラジェリソン，ホリソア
フェーブル−ショーヴェ，アラン
ボエダ，ファビアン
Original Assignee
センター ナショナル デ ラ リシェルシェ サイエンティフィック（シーエヌアールエス）
センター ナショナル デ ラ リシェルシェ サイエンティフィック（シーエヌアールエス）
ユニバーシティ デ ナント
ユニバーシティ デ ナント
ユニバーシティ ダンガース
ユニバーシティ ダンガース
ユニバーシティ ドゥ メイン
ユニバーシティ ドゥ メイン
インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル）
インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル）
センター ホスピタリア ユニバーシタイア デ ナント
センター ホスピタリア ユニバーシタイア デ ナント
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016562070A 2014-01-07 2015-01-07 放射性医薬品化合物の製造のためのイオン性液体担持有機スズ試薬 Expired - Fee Related JP6639411B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14150296.3A EP2891657A1 (en) 2014-01-07 2014-01-07 Ionic liquid supported organotin reagents for the manufacturing of radiopharmaceuticals compounds
EP14150296.3 2014-01-07
PCT/EP2015/050180 WO2015104300A1 (en) 2014-01-07 2015-01-07 Ionic liquid supported organotin reagents for the manufacturing of radiopharmaceuticals compounds

Publications (3)

Publication Number Publication Date
JP2017504658A JP2017504658A (ja) 2017-02-09
JP2017504658A5 JP2017504658A5 (https=) 2018-02-01
JP6639411B2 true JP6639411B2 (ja) 2020-02-05

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JP2016562070A Expired - Fee Related JP6639411B2 (ja) 2014-01-07 2015-01-07 放射性医薬品化合物の製造のためのイオン性液体担持有機スズ試薬

Country Status (8)

Country Link
US (1) US9714261B2 (https=)
EP (2) EP2891657A1 (https=)
JP (1) JP6639411B2 (https=)
CA (1) CA2936034A1 (https=)
DK (1) DK3092243T3 (https=)
ES (1) ES2746255T3 (https=)
PL (1) PL3092243T3 (https=)
WO (1) WO2015104300A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112430243B (zh) * 2019-08-24 2023-03-21 江西师范大学 一种制备硫酯类化合物的方法
WO2021119198A1 (en) * 2019-12-09 2021-06-17 Cage Bio, Inc. Topical delivery of rna interference agents using ionic liquid
KR20220156001A (ko) * 2020-02-21 2022-11-24 국립대학법인 홋가이도 다이가쿠 방향족 아스타틴 화합물의 제조 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510522A (en) 1995-02-22 1996-04-23 Regents Of The University Of California Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- 18 F!fluoro-1-dopa
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
CA2345710C (en) 1997-10-02 2008-12-30 The University Of Western Ontario Preparation of radiolabelled haloaromatics via polymer-bound intermediates
DE19928911B4 (de) 1999-06-24 2006-06-29 Forschungszentrum Rossendorf E.V. Verfahren zur Herstellung von 3-0-Methyl-6-[18F]Fluor-DOPA, (3-0-Methyl-6-[18F]Fluor-L-4-hydroxyphenylalanin, 3-(2-[18F]Fluor-4-hydroxy-5-methoxy-phenyl)-2-amino-propansäure)
DE19949237B4 (de) 1999-10-13 2004-07-29 Abx Advanced Biochemical Compounds Biomedizinische Forschungsreagenzien Gmbh Vorstufenverbindung für Radiodiagnostika und Verfahren zu ihrer Herstellung
WO2010059943A2 (en) 2008-11-20 2010-05-27 President And Fellows Of Harvard College Fluorination of organic compounds

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Publication number Publication date
US20160326194A1 (en) 2016-11-10
DK3092243T3 (da) 2019-09-30
EP2891657A1 (en) 2015-07-08
WO2015104300A1 (en) 2015-07-16
ES2746255T3 (es) 2020-03-05
EP3092243A1 (en) 2016-11-16
PL3092243T3 (pl) 2020-02-28
JP2017504658A (ja) 2017-02-09
EP3092243B1 (en) 2019-06-19
CA2936034A1 (en) 2015-07-16
US9714261B2 (en) 2017-07-25

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