JP6612619B2 - 非複製型ウイルス由来粒子及びその使用 - Google Patents

非複製型ウイルス由来粒子及びその使用 Download PDF

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Publication number
JP6612619B2
JP6612619B2 JP2015548131A JP2015548131A JP6612619B2 JP 6612619 B2 JP6612619 B2 JP 6612619B2 JP 2015548131 A JP2015548131 A JP 2015548131A JP 2015548131 A JP2015548131 A JP 2015548131A JP 6612619 B2 JP6612619 B2 JP 6612619B2
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nrrp
cells
virus
cell
protein
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JP2016501538A (ja
JP2016501538A5 (https=
Inventor
コンラッド,デイビッド
バテンチュク,コーリー
ルブーフ,ファブリス
キャメロン ベル,ジョン
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Celverum Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/766Rhabdovirus, e.g. vesicular stomatitis virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • C12N7/045Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C12N2760/20021Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
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    • C12N2760/20061Methods of inactivation or attenuation
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/20011Rhabdoviridae
    • C12N2760/20211Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/00011Details
    • C12N2760/20011Rhabdoviridae
    • C12N2760/20211Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20232Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011Details
    • C12N2760/20011Rhabdoviridae
    • C12N2760/20211Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20261Methods of inactivation or attenuation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011Details
    • C12N2760/20011Rhabdoviridae
    • C12N2760/20211Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20261Methods of inactivation or attenuation
    • C12N2760/20263Methods of inactivation or attenuation by chemical treatment

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2015548131A 2012-12-21 2013-12-20 非複製型ウイルス由来粒子及びその使用 Expired - Fee Related JP6612619B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261740856P 2012-12-21 2012-12-21
US61/740,856 2012-12-21
US201361835310P 2013-06-14 2013-06-14
US61/835,310 2013-06-14
PCT/CA2013/051009 WO2014094182A1 (en) 2012-12-21 2013-12-20 Non-replicating virus-derived particles and uses thereof

Related Child Applications (1)

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JP2019165067A Division JP2020014467A (ja) 2012-12-21 2019-09-11 非複製型ウイルス由来粒子及びその使用

Publications (3)

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JP2016501538A JP2016501538A (ja) 2016-01-21
JP2016501538A5 JP2016501538A5 (https=) 2017-02-02
JP6612619B2 true JP6612619B2 (ja) 2019-11-27

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JP2015548131A Expired - Fee Related JP6612619B2 (ja) 2012-12-21 2013-12-20 非複製型ウイルス由来粒子及びその使用
JP2019165067A Pending JP2020014467A (ja) 2012-12-21 2019-09-11 非複製型ウイルス由来粒子及びその使用

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US (2) US11110138B2 (https=)
EP (1) EP2935569B1 (https=)
JP (2) JP6612619B2 (https=)
KR (1) KR102167497B1 (https=)
CN (1) CN105121636A (https=)
AU (1) AU2013362761B2 (https=)
BR (1) BR112015015045A8 (https=)
CA (1) CA2896162C (https=)
CL (1) CL2015001738A1 (https=)
ES (1) ES2745599T3 (https=)
IL (1) IL239486B (https=)
MX (1) MX376266B (https=)
MY (1) MY174912A (https=)
PH (1) PH12015501442A1 (https=)
RU (1) RU2705556C2 (https=)
SG (2) SG11201504843UA (https=)
WO (1) WO2014094182A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014094182A1 (en) * 2012-12-21 2014-06-26 Ottawa Hospital Research Institute Non-replicating virus-derived particles and uses thereof
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
CN109985244A (zh) * 2017-12-29 2019-07-09 广州威溶特医药科技有限公司 E3连接酶抑制剂和溶瘤病毒在制备抗肿瘤药物的应用
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN109432098B (zh) * 2018-11-20 2021-04-13 天津大学 化合物ps-341在制备小rna病毒科肠道病毒属病毒抑制剂的应用
EP3708176A1 (en) * 2019-03-15 2020-09-16 Centre National De La Recherche Scientifique -Cnrs- Mutant vsv ectodomain polypeptide and uses thereof

Family Cites Families (17)

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US5106619A (en) 1983-12-20 1992-04-21 Diamond Scientific Co. Preparation of inactivated viral vaccines
HK1052950B (en) * 2000-06-26 2005-06-24 Wellstat Biologics Corporation Purging of cells using viruses
JP2005537802A (ja) 2002-09-09 2005-12-15 ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション ラブドウイルスの組み換え型変異体及びその使用方法
JP4708027B2 (ja) * 2002-10-01 2011-06-22 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド 抗癌組成物および抗感染疾患組成物ならびにこれらを使用する方法
AU2003279770A1 (en) 2002-10-01 2004-04-23 Novartis Vaccines And Diagnostics, Inc. Anti-cancer and anti-infectious disease compositions and methods for using same
CN100579579C (zh) * 2002-10-01 2010-01-13 诺华疫苗和诊断公司 抗癌及抗感染性疾病组合物及其使用方法
DE602004018284D1 (de) 2003-03-27 2009-01-22 Ottawa Health Research Inst Mutante vesicular stomatitis viren und deren verwendungen
US7807176B2 (en) * 2004-03-19 2010-10-05 Genomidea, Inc. Polypeptide promoting vascular endothelial cell growth
US8703467B2 (en) * 2004-05-27 2014-04-22 Baxter International Inc. Inactivation of a pathogen in a sample by a treatment with formalin and UV light
CA2663034C (en) 2006-09-15 2016-05-03 Ottawa Health Research Institute Oncolytic rhabdovirus
JP5547640B2 (ja) * 2008-09-16 2014-07-16 ジェノミディア株式会社 前立腺癌の治療・予防剤
CA2836117C (en) * 2009-12-10 2017-08-15 Ottawa Hospital Research Institute Oncolytic rhabdovirus
US20130302368A1 (en) * 2011-01-27 2013-11-14 Boro Dropulic Advanced Prime and Boost Vaccine
CN103403594B (zh) * 2011-02-02 2016-11-23 康宁光缆系统有限责任公司 适用于为设备机架中的光学底板建立光学连接的稠密的光阀遮蔽的光纤连接器及总成
WO2012122649A1 (en) * 2011-03-15 2012-09-20 Ottawa Hospital Research Institute Recombinant orf virus
US9623096B2 (en) * 2011-11-09 2017-04-18 Celverum Inc. Virally infected hematopoietic cells and uses thereof
WO2014094182A1 (en) * 2012-12-21 2014-06-26 Ottawa Hospital Research Institute Non-replicating virus-derived particles and uses thereof

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Publication number Publication date
CN105121636A (zh) 2015-12-02
US20210346441A1 (en) 2021-11-11
AU2013362761A1 (en) 2015-07-16
CA2896162C (en) 2021-10-12
JP2016501538A (ja) 2016-01-21
SG10201704903YA (en) 2017-07-28
US11110138B2 (en) 2021-09-07
CL2015001738A1 (es) 2015-12-18
IL239486B (en) 2019-08-29
NZ709439A (en) 2020-09-25
MX376266B (es) 2025-03-07
MY174912A (en) 2020-05-21
RU2015128766A (ru) 2017-01-26
EP2935569B1 (en) 2019-05-01
BR112015015045A8 (pt) 2018-01-23
CA2896162A1 (en) 2014-06-26
JP2020014467A (ja) 2020-01-30
RU2705556C2 (ru) 2019-11-07
MX2015008155A (es) 2016-02-05
KR102167497B1 (ko) 2020-10-20
EP2935569A4 (en) 2016-08-03
PH12015501442A1 (en) 2015-09-14
EP2935569A1 (en) 2015-10-28
AU2013362761B2 (en) 2019-08-01
WO2014094182A1 (en) 2014-06-26
US20150320810A1 (en) 2015-11-12
IL239486A0 (en) 2015-07-30
SG11201504843UA (en) 2015-07-30
HK1210624A1 (en) 2016-04-29
ES2745599T3 (es) 2020-03-02
KR20150112957A (ko) 2015-10-07

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