AU2013362761B2 - Non-replicating virus-derived particles and uses thereof - Google Patents
Non-replicating virus-derived particles and uses thereof Download PDFInfo
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- AU2013362761B2 AU2013362761B2 AU2013362761A AU2013362761A AU2013362761B2 AU 2013362761 B2 AU2013362761 B2 AU 2013362761B2 AU 2013362761 A AU2013362761 A AU 2013362761A AU 2013362761 A AU2013362761 A AU 2013362761A AU 2013362761 B2 AU2013362761 B2 AU 2013362761B2
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| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
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| US20110223148A1 (en) * | 2008-09-16 | 2011-09-15 | Genomidea Inc. | Therapeutic/prophylactic agent for prostate cancer |
Non-Patent Citations (2)
| Title |
|---|
| Brun J et al, "Identification of genetically modified Maraba virus as an oncolytic rhabdovirus", Molecular Therapy, 2010, 18(8):1440-1449. doi: 10.1038/mt.2010.103. * |
| Kurooka M et al, "Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells", Cancer Research, 2007, 67(1):227-236 * |
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