JP6609306B2 - ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのその使用 - Google Patents

６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのその使用 Download PDF

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JP6609306B2
JP6609306B2 JP2017505447A JP2017505447A JP6609306B2 JP 6609306 B2 JP6609306 B2 JP 6609306B2 JP 2017505447 A JP2017505447 A JP 2017505447A JP 2017505447 A JP2017505447 A JP 2017505447A JP 6609306 B2 JP6609306 B2 JP 6609306B2
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phenyl
methyl
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JP2017526659A (ja
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ディエゴ，セルジオ−アルバール アロンソ−デ
ゴール，ミシェル，ルク，マリア ヴァン
マーティン−マーティン，マリア，ルツ
コンデ−シード，スサナ
アンドレス−ジル，ホセ，イグナシオ
デルガド−ゴンザレス，オスカー
トレサダーン，ギャリー，ジョン
トラバンコ−スアレス，アンドレス，アヴェリノ
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ヤンセン ファーマシューティカ エヌ．ベー．
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017505447A 2014-08-01 2015-07-30 ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのその使用 Expired - Fee Related JP6609306B2 (ja)

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Application Number Priority Date Filing Date Title
EP14179600.3 2014-08-01
EP14179600 2014-08-01
EP14196083 2014-12-03
EP14196083.1 2014-12-03
PCT/EP2015/067572 WO2016016395A1 (en) 2014-08-01 2015-07-30 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors

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JP2017526659A JP2017526659A (ja) 2017-09-14
JP2017526659A5 JP2017526659A5 (enExample) 2018-09-06
JP6609306B2 true JP6609306B2 (ja) 2019-11-20

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US (2) US10005785B2 (enExample)
EP (1) EP3174883B1 (enExample)
JP (1) JP6609306B2 (enExample)
KR (1) KR102531680B1 (enExample)
CN (1) CN107018662B (enExample)
AU (1) AU2015295313B2 (enExample)
BR (1) BR112017001861A2 (enExample)
CA (1) CA2954094C (enExample)
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TW (1) TWI688566B (enExample)
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RU2711382C2 (ru) 2014-12-03 2020-01-16 Янссен Фармацевтика Нв 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ MGLUR2
EP3226915B1 (en) 2014-12-03 2019-02-20 Janssen Pharmaceutica NV Radiolabelled mglur2 pet ligands
RS60981B1 (sr) 2015-12-18 2020-11-30 Janssen Pharmaceutica Nv Radiooznačeni mglur2/3 pet ligandi
JP6929285B2 (ja) 2015-12-18 2021-09-01 ヤンセン ファーマシューティカ エヌ．ベー． 放射性標識ｍＧｌｕＲ２／３ＰＥＴリガンド

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