JP6597932B2 - 細胞捕捉用フィルタ、細胞捕捉用フィルタの製造方法、および細胞捕捉用フィルタの劣化判定方法 - Google Patents
細胞捕捉用フィルタ、細胞捕捉用フィルタの製造方法、および細胞捕捉用フィルタの劣化判定方法 Download PDFInfo
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- KERTUBUCQCSNJU-UHFFFAOYSA-L nickel(2+);disulfamate Chemical compound [Ni+2].NS([O-])(=O)=O.NS([O-])(=O)=O KERTUBUCQCSNJU-UHFFFAOYSA-L 0.000 description 1
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Description
(フィルタの全体構成)
図1は、本発明に係る実施の形態1の細胞捕捉用フィルタ1(以降、フィルタ1とする。)の概略図を示す。図2は、フィルタ1の部分拡大図を示す。図2中のX、Y方向は、それぞれフィルタ1の表面沿いの方向であって互いに直交する方向であり、Z方向は、フィルタ1の厚み方向であり、X方向およびY方向に直交する方向である。
次に、本実施の形態1の細胞捕捉用フィルタ1において、金属製多孔膜10の経年劣化を判定する方法の一例を説明する。フィルタ1の劣化判定方法のフローチャートを図4に示す。
次に、本実施の形態1の細胞捕捉用フィルタ1の製造方法の一例について説明する。フィルタ1の製造方法のフローチャートを図5に示し、フィルタ1の製造方法におけるそれぞれの製造過程の部分断面図(中央側領域R1と周縁領域R2との境界近傍の部分断面図)を図6(A)〜図6(F)に示す。
(実施例)
本実施例では、第1金属として銅を主成分とする金属を用い、第2金属としてニッケルを用いて、第2金属を主材料とする金属製多孔膜10のいずれかの主面の一部に第1金属によるインジケータ20が付着したフィルタ1を作製した。具体的には、図5のステップS21からS26のステップを実施することによりフィルタ1を作製した。第1金属としては銅が99wt%である金属を用い、第2金属としてはニッケルが99wt%である金属を用いた。これらの金属の成分割合は、ICP−AES(誘導結合プラズマ発光分光分析装置)を用いて測定した値である。
比較例にかかる細胞捕捉用フィルタの製造方法について説明する。
10 金属製多孔膜
11 貫通孔
20 インジケータ
PS1 第1主面
PS2 第2主面
R1 中央側領域
R2 周縁領域
Claims (5)
- 互いに対向する主面を貫通する複数の貫通孔を有する金属製多孔膜を備え、
前記金属製多孔膜は、金、白金およびパラジウムから選択される元素とニッケルとの合金、またはニッケルを主成分とする金属により形成されており、
前記金属製多孔膜のいずれか一方の前記主面の一部に、銅を主成分とする金属が付着している、細胞捕捉用フィルタ。 - 前記金属製多孔膜は、前記複数の貫通孔が配置された中央側領域と、前記中央側領域を囲むように配置された周縁領域と、を有し、
前記金属は、前記周縁領域に付着している、請求項1に記載の細胞捕捉用フィルタ。 - 互いに対向する主面を貫通する複数の貫通孔を有する金属製多孔膜を備える、同一ロットの細胞捕捉用フィルタ群であって、
請求項1または2に記載の前記細胞捕捉用フィルタが少なくとも1つ含まれている、細胞捕捉用フィルタ群。 - 複数の貫通孔を有する金属製多孔膜を備える細胞捕捉用フィルタの製造方法であって、
基板の表面に、銅を主成分とする金属膜を形成する工程と、
前記金属膜の表面にレジスト膜を形成する工程と、
前記レジスト膜を露光して、前記金属膜を部分的に露出させる複数の溝部を有するレジスト像を形成する工程と、
前記金属膜を給電電極としてめっき処理を行い、金、白金、パラジウムから選択される元素とニッケルとの合金、またはニッケルを主成分とする金属を、前記溝部内に析出させて金属製多孔膜を形成する工程と、
前記レジスト像を除去する工程と、
前記基板および前記金属膜を除去する工程と、を含み、
前記基板および前記金属膜を除去する工程において、前記金属膜を構成する銅を主成分とする金属を前記金属製多孔膜の表面に残すようにする、細胞捕捉用フィルタの製造方法。 - 金属製多孔膜を備える細胞捕捉用フィルタの劣化度合いを判定する劣化判定方法であって、
金、白金およびパラジウムから選択される元素とニッケルとの合金、またはニッケルを主成分とする金属により形成された前記金属製多孔膜のいずれか一方の主面の一部に、銅を主成分とする金属を付着させた細胞捕捉用フィルタを準備する工程と、
前記金属製多孔膜に付着している銅を主成分とする金属の状態変化に基づいて、前記金属製多孔膜の劣化度合いを判定する工程と、を含む、細胞捕捉用フィルタの劣化判定方法。
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