JP6594909B2 - リン脂質組成物、その凍結乾燥方法および凍結乾燥物 - Google Patents

リン脂質組成物、その凍結乾燥方法および凍結乾燥物 Download PDF

Info

Publication number
JP6594909B2
JP6594909B2 JP2016572258A JP2016572258A JP6594909B2 JP 6594909 B2 JP6594909 B2 JP 6594909B2 JP 2016572258 A JP2016572258 A JP 2016572258A JP 2016572258 A JP2016572258 A JP 2016572258A JP 6594909 B2 JP6594909 B2 JP 6594909B2
Authority
JP
Japan
Prior art keywords
composition
dppe
mol
peg
phosphatidylethanolamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016572258A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017517533A5 (enExample
JP2017517533A (ja
Inventor
エヴァン， シー． アンガー，
ダニエル， シー． エバンズ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2017517533A publication Critical patent/JP2017517533A/ja
Publication of JP2017517533A5 publication Critical patent/JP2017517533A5/ja
Application granted granted Critical
Publication of JP6594909B2 publication Critical patent/JP6594909B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
JP2016572258A 2014-06-12 2015-06-12 リン脂質組成物、その凍結乾燥方法および凍結乾燥物 Active JP6594909B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462011469P 2014-06-12 2014-06-12
US62/011,469 2014-06-12
PCT/US2015/035681 WO2015192093A1 (en) 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same

Publications (3)

Publication Number Publication Date
JP2017517533A JP2017517533A (ja) 2017-06-29
JP2017517533A5 JP2017517533A5 (enExample) 2018-07-12
JP6594909B2 true JP6594909B2 (ja) 2019-10-23

Family

ID=54834464

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016572258A Active JP6594909B2 (ja) 2014-06-12 2015-06-12 リン脂質組成物、その凍結乾燥方法および凍結乾燥物

Country Status (8)

Country Link
US (3) US9801959B2 (enExample)
EP (1) EP3154591B1 (enExample)
JP (1) JP6594909B2 (enExample)
KR (1) KR102379534B1 (enExample)
CN (1) CN107106692B (enExample)
AU (1) AU2015274259B2 (enExample)
CA (1) CA2951922C (enExample)
WO (1) WO2015192093A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102618877B1 (ko) 2014-12-31 2023-12-28 랜티우스 메디컬 이메징, 인크. 지질-캡슐화된 기체 마이크로스피어 조성물 및 관련 방법
AU2016377361B2 (en) * 2015-12-21 2022-07-07 Nuvox Pharma Llc Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof
WO2017184672A1 (en) * 2016-04-19 2017-10-26 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
EP3452108A4 (en) 2016-05-04 2019-12-25 Lantheus Medical Imaging, Inc. METHOD AND DEVICES FOR THE PRODUCTION OF ULTRASONIC CONTRASTING AGENTS
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3530266A1 (en) 2018-02-27 2019-08-28 LipoCoat B.V. A lipid-based coating composition, and an object having a lipid-based coating
KR20210018789A (ko) * 2018-03-29 2021-02-18 마이크로바스큘러 테라퓨틱스 엘엘씨 알츠하이머 병을 검출하고 치료하기 위한 조성물 및 방법
EP3773752A4 (en) * 2018-03-29 2022-01-12 Case Western Reserve University Stabilized nanobubbles and microbubbles for diagnostic and therapeutic applications
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20220387460A1 (en) * 2019-11-11 2022-12-08 Washington University Liposome compositions and methods of treatment targeted to tumor endothelium
CN111729094B (zh) * 2020-07-23 2021-07-02 四川大学华西医院 类磷脂两亲性嵌段共聚物基超声造影剂及其制备方法
CN116897055A (zh) * 2020-12-27 2023-10-17 索尔斯蒂斯制药有限公司 用于混合旨在用于体内使用的磷脂组合物的筒
NL2027237B1 (en) 2020-12-27 2022-07-21 Solstice Pharmaceuticals B V Process for controlled manufacturing of mono-disperse microbubbles
JP2024501982A (ja) 2020-12-27 2024-01-17 ソルスティス ファーマシューティカルズ ビー．ブイ． 体内使用を意図したリン脂質組成物を混合するためのカートリッジ
CA3251365A1 (en) * 2022-02-09 2023-08-17 Lantheus Medical Imaging Inc Compositions of nano/micro-gas bubbles and their uses

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
EP0833608A2 (en) * 1995-06-07 1998-04-08 Alliance Pharmaceutical Corporation Reverse fluorocarbon emulsion compositions for drug delivery
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
ES2289188T3 (es) * 1996-09-11 2008-02-01 Bristol-Myers Squibb Medical Imaging, Inc. Procedimiento para la obtencion de imagenes para el diagnostico usando un agente de contraste y un vasodilatador.
US6572840B1 (en) * 1999-07-28 2003-06-03 Bristol-Myers Squibb Pharma Company Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent
US7357937B2 (en) 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
US20050025710A1 (en) * 2003-07-29 2005-02-03 Michel Schneider Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
EP1793865A4 (en) * 2004-08-05 2009-05-13 Baylor Res Inst GENETIC OR DRUG DELIVERY SYSTEM
EP2253308A1 (en) * 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same

Also Published As

Publication number Publication date
CA2951922A1 (en) 2015-12-17
WO2015192093A1 (en) 2015-12-17
US20180092995A1 (en) 2018-04-05
US9801959B2 (en) 2017-10-31
CN107106692B (zh) 2021-01-05
US10493173B2 (en) 2019-12-03
CN107106692A (zh) 2017-08-29
US11160885B2 (en) 2021-11-02
EP3154591B1 (en) 2023-10-11
AU2015274259B2 (en) 2019-04-18
US20160000943A1 (en) 2016-01-07
EP3154591A4 (en) 2018-02-14
JP2017517533A (ja) 2017-06-29
KR20170016462A (ko) 2017-02-13
EP3154591C0 (en) 2023-10-11
CA2951922C (en) 2023-02-28
US20190184038A1 (en) 2019-06-20
AU2015274259A1 (en) 2017-01-05
KR102379534B1 (ko) 2022-03-25
EP3154591A1 (en) 2017-04-19

Similar Documents

Publication Publication Date Title
JP6594909B2 (ja) リン脂質組成物、その凍結乾燥方法および凍結乾燥物
CN1278740C (zh) 造影剂或有关造影剂的改进
CN1102045C (zh) 新的含类脂和稳定剂的组合物
CN101528268B (zh) 具有聚合物修饰的脂质的充气微囊泡
JP4670083B2 (ja) 超音波造影剤およびその製造方法
JP6803839B2 (ja) 標的化されたガス入りの微小胞の製剤
US20200390911A1 (en) Lipid encapsulated gas microsphere compositions and related methods
CN105026030B (zh) 充气微泡
WO2020127992A1 (en) Ultrasound contrast agent and methods for use thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170516

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180531

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180531

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190123

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190129

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190425

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190827

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190925

R150 Certificate of patent or registration of utility model

Ref document number: 6594909

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250