JP6594909B2 - リン脂質組成物、その凍結乾燥方法および凍結乾燥物 - Google Patents

リン脂質組成物、その凍結乾燥方法および凍結乾燥物 Download PDF

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JP6594909B2
JP6594909B2 JP2016572258A JP2016572258A JP6594909B2 JP 6594909 B2 JP6594909 B2 JP 6594909B2 JP 2016572258 A JP2016572258 A JP 2016572258A JP 2016572258 A JP2016572258 A JP 2016572258A JP 6594909 B2 JP6594909 B2 JP 6594909B2
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phosphatidylethanolamine
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JP2017517533A (ja
JP2017517533A5 (enExample
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エヴァン， シー． アンガー，
ダニエル， シー． エバンズ，
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical & Material Sciences (AREA)
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JP2016572258A 2014-06-12 2015-06-12 リン脂質組成物、その凍結乾燥方法および凍結乾燥物 Active JP6594909B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462011469P 2014-06-12 2014-06-12
US62/011,469 2014-06-12
PCT/US2015/035681 WO2015192093A1 (en) 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same

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JP2017517533A JP2017517533A (ja) 2017-06-29
JP2017517533A5 JP2017517533A5 (enExample) 2018-07-12
JP6594909B2 true JP6594909B2 (ja) 2019-10-23

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JP2016572258A Active JP6594909B2 (ja) 2014-06-12 2015-06-12 リン脂質組成物、その凍結乾燥方法および凍結乾燥物

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US (3) US9801959B2 (enExample)
EP (1) EP3154591B1 (enExample)
JP (1) JP6594909B2 (enExample)
KR (1) KR102379534B1 (enExample)
CN (1) CN107106692B (enExample)
AU (1) AU2015274259B2 (enExample)
CA (1) CA2951922C (enExample)
WO (1) WO2015192093A1 (enExample)

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AU2015374286B2 (en) 2014-12-31 2021-11-18 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
IL260206B2 (en) * 2015-12-21 2023-04-01 Nuvox Pharma Llc Preparations containing a nanoemulsion of fluorocarbons and methods for their preparation
US20190117800A1 (en) * 2016-04-19 2019-04-25 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
IL262647B2 (en) 2016-05-04 2023-03-01 Lantheus Medical Imaging Inc Methods and devices for preparing sharpness factors for ultrasound
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3530266A1 (en) 2018-02-27 2019-08-28 LipoCoat B.V. A lipid-based coating composition, and an object having a lipid-based coating
AU2019243579B2 (en) * 2018-03-29 2024-05-09 Microvascular Therapeutics LLC Compositions and methods of detecting and treating Alzheimer's disease
WO2019191557A1 (en) * 2018-03-29 2019-10-03 Case Wester Reserve University Stabilized nanobubbles and microbubbles for diagnostic and therapeutic applications
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
GB201908352D0 (en) * 2019-06-11 2019-07-24 Innovation Ulster Ltd Sonodynamic therapy
WO2021096951A1 (en) * 2019-11-11 2021-05-20 Washington University Liposome compositions and methods of treatment targeted to tumor endothelium
CN111729094B (zh) * 2020-07-23 2021-07-02 四川大学华西医院 类磷脂两亲性嵌段共聚物基超声造影剂及其制备方法
CN116897055A (zh) * 2020-12-27 2023-10-17 索尔斯蒂斯制药有限公司 用于混合旨在用于体内使用的磷脂组合物的筒
NL2027237B1 (en) * 2020-12-27 2022-07-21 Solstice Pharmaceuticals B V Process for controlled manufacturing of mono-disperse microbubbles
US20240299653A1 (en) 2020-12-27 2024-09-12 Solstice Pharmaceuticals B.V. A Cartridge for Mixing a Liquid Intended for Intracorporeal Use
US20250195698A1 (en) * 2022-02-09 2025-06-19 Lantheus Medical Imaging, Inc. Gas nano/micro-bubble compositions and uses thereof

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
HUP9900879A2 (hu) * 1995-06-07 1999-08-30 Alliance Pharmaceutical Corp. Fordított fluor-szénhidrogén emulziós készítmények gyógyszeradagoláshoz
DE69718519T2 (de) * 1996-09-11 2003-11-06 Imarx Pharmaceutical Corp., Tucson Verbesserte verfahren zur diagnostischen bilderzeugung unter verwendung eines kontrastmittels und eines vasodilators
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6572840B1 (en) * 1999-07-28 2003-06-03 Bristol-Myers Squibb Pharma Company Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent
US7357937B2 (en) * 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
US20050025710A1 (en) * 2003-07-29 2005-02-03 Michel Schneider Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
CN101389273B (zh) * 2004-08-05 2012-09-05 贝勒研究院 基因或药物递送系统
EP2253308A1 (en) * 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same

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Publication number Publication date
US10493173B2 (en) 2019-12-03
CN107106692A (zh) 2017-08-29
KR20170016462A (ko) 2017-02-13
EP3154591C0 (en) 2023-10-11
EP3154591A1 (en) 2017-04-19
US20190184038A1 (en) 2019-06-20
JP2017517533A (ja) 2017-06-29
AU2015274259A1 (en) 2017-01-05
CA2951922C (en) 2023-02-28
AU2015274259B2 (en) 2019-04-18
US9801959B2 (en) 2017-10-31
EP3154591A4 (en) 2018-02-14
CA2951922A1 (en) 2015-12-17
CN107106692B (zh) 2021-01-05
EP3154591B1 (en) 2023-10-11
KR102379534B1 (ko) 2022-03-25
US20180092995A1 (en) 2018-04-05
US11160885B2 (en) 2021-11-02
US20160000943A1 (en) 2016-01-07
WO2015192093A1 (en) 2015-12-17

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