AU2015274259B2 - Phospholipid composition and microbubbles and emulsions formed using same - Google Patents

Phospholipid composition and microbubbles and emulsions formed using same Download PDF

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Publication number
AU2015274259B2
AU2015274259B2 AU2015274259A AU2015274259A AU2015274259B2 AU 2015274259 B2 AU2015274259 B2 AU 2015274259B2 AU 2015274259 A AU2015274259 A AU 2015274259A AU 2015274259 A AU2015274259 A AU 2015274259A AU 2015274259 B2 AU2015274259 B2 AU 2015274259B2
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Australia
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dppe
lipid
composition
mole percent
peg
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AU2015274259A1 (en
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Daniel C. Evans
Evan C. Unger
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
AU2015274259A 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same Active AU2015274259B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462011469P 2014-06-12 2014-06-12
US62/011,469 2014-06-12
PCT/US2015/035681 WO2015192093A1 (en) 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same

Publications (2)

Publication Number Publication Date
AU2015274259A1 AU2015274259A1 (en) 2017-01-05
AU2015274259B2 true AU2015274259B2 (en) 2019-04-18

Family

ID=54834464

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015274259A Active AU2015274259B2 (en) 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same

Country Status (8)

Country Link
US (3) US9801959B2 (enExample)
EP (1) EP3154591B1 (enExample)
JP (1) JP6594909B2 (enExample)
KR (1) KR102379534B1 (enExample)
CN (1) CN107106692B (enExample)
AU (1) AU2015274259B2 (enExample)
CA (1) CA2951922C (enExample)
WO (1) WO2015192093A1 (enExample)

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KR102618877B1 (ko) 2014-12-31 2023-12-28 랜티우스 메디컬 이메징, 인크. 지질-캡슐화된 기체 마이크로스피어 조성물 및 관련 방법
AU2016377361B2 (en) * 2015-12-21 2022-07-07 Nuvox Pharma Llc Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof
WO2017184672A1 (en) * 2016-04-19 2017-10-26 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
EP3452108A4 (en) 2016-05-04 2019-12-25 Lantheus Medical Imaging, Inc. METHOD AND DEVICES FOR THE PRODUCTION OF ULTRASONIC CONTRASTING AGENTS
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3530266A1 (en) 2018-02-27 2019-08-28 LipoCoat B.V. A lipid-based coating composition, and an object having a lipid-based coating
KR20210018789A (ko) * 2018-03-29 2021-02-18 마이크로바스큘러 테라퓨틱스 엘엘씨 알츠하이머 병을 검출하고 치료하기 위한 조성물 및 방법
EP3773752A4 (en) * 2018-03-29 2022-01-12 Case Western Reserve University Stabilized nanobubbles and microbubbles for diagnostic and therapeutic applications
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20220387460A1 (en) * 2019-11-11 2022-12-08 Washington University Liposome compositions and methods of treatment targeted to tumor endothelium
CN111729094B (zh) * 2020-07-23 2021-07-02 四川大学华西医院 类磷脂两亲性嵌段共聚物基超声造影剂及其制备方法
CN116897055A (zh) * 2020-12-27 2023-10-17 索尔斯蒂斯制药有限公司 用于混合旨在用于体内使用的磷脂组合物的筒
NL2027237B1 (en) 2020-12-27 2022-07-21 Solstice Pharmaceuticals B V Process for controlled manufacturing of mono-disperse microbubbles
JP2024501982A (ja) 2020-12-27 2024-01-17 ソルスティス ファーマシューティカルズ ビー．ブイ． 体内使用を意図したリン脂質組成物を混合するためのカートリッジ
CA3251365A1 (en) * 2022-02-09 2023-08-17 Lantheus Medical Imaging Inc Compositions of nano/micro-gas bubbles and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010133700A1 (en) * 2009-05-22 2010-11-25 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
EP0833608A2 (en) * 1995-06-07 1998-04-08 Alliance Pharmaceutical Corporation Reverse fluorocarbon emulsion compositions for drug delivery
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
ES2289188T3 (es) * 1996-09-11 2008-02-01 Bristol-Myers Squibb Medical Imaging, Inc. Procedimiento para la obtencion de imagenes para el diagnostico usando un agente de contraste y un vasodilatador.
US6572840B1 (en) * 1999-07-28 2003-06-03 Bristol-Myers Squibb Pharma Company Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent
US7357937B2 (en) 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
US20050025710A1 (en) * 2003-07-29 2005-02-03 Michel Schneider Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
EP1793865A4 (en) * 2004-08-05 2009-05-13 Baylor Res Inst GENETIC OR DRUG DELIVERY SYSTEM
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010133700A1 (en) * 2009-05-22 2010-11-25 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy

Also Published As

Publication number Publication date
CA2951922A1 (en) 2015-12-17
WO2015192093A1 (en) 2015-12-17
US20180092995A1 (en) 2018-04-05
US9801959B2 (en) 2017-10-31
CN107106692B (zh) 2021-01-05
US10493173B2 (en) 2019-12-03
CN107106692A (zh) 2017-08-29
US11160885B2 (en) 2021-11-02
EP3154591B1 (en) 2023-10-11
US20160000943A1 (en) 2016-01-07
EP3154591A4 (en) 2018-02-14
JP2017517533A (ja) 2017-06-29
KR20170016462A (ko) 2017-02-13
EP3154591C0 (en) 2023-10-11
CA2951922C (en) 2023-02-28
US20190184038A1 (en) 2019-06-20
AU2015274259A1 (en) 2017-01-05
JP6594909B2 (ja) 2019-10-23
KR102379534B1 (ko) 2022-03-25
EP3154591A1 (en) 2017-04-19

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