CA2951922C - Phospholipid composition and microbubbles and emulsions formed using same - Google Patents

Phospholipid composition and microbubbles and emulsions formed using same Download PDF

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Publication number
CA2951922C
CA2951922C CA2951922A CA2951922A CA2951922C CA 2951922 C CA2951922 C CA 2951922C CA 2951922 A CA2951922 A CA 2951922A CA 2951922 A CA2951922 A CA 2951922A CA 2951922 C CA2951922 C CA 2951922C
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CA
Canada
Prior art keywords
dppe
lipid
composition
peg
mole percent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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CA2951922A
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English (en)
French (fr)
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CA2951922A1 (en
Inventor
Evan C. Unger
Daniel C. Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microvascular Therapeutics LLC
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Microvascular Therapeutics LLC
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Publication date
Application filed by Microvascular Therapeutics LLC filed Critical Microvascular Therapeutics LLC
Publication of CA2951922A1 publication Critical patent/CA2951922A1/en
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Publication of CA2951922C publication Critical patent/CA2951922C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
CA2951922A 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same Active CA2951922C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462011469P 2014-06-12 2014-06-12
US62/011,469 2014-06-12
PCT/US2015/035681 WO2015192093A1 (en) 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same

Publications (2)

Publication Number Publication Date
CA2951922A1 CA2951922A1 (en) 2015-12-17
CA2951922C true CA2951922C (en) 2023-02-28

Family

ID=54834464

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2951922A Active CA2951922C (en) 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same

Country Status (8)

Country Link
US (3) US9801959B2 (enExample)
EP (1) EP3154591B1 (enExample)
JP (1) JP6594909B2 (enExample)
KR (1) KR102379534B1 (enExample)
CN (1) CN107106692B (enExample)
AU (1) AU2015274259B2 (enExample)
CA (1) CA2951922C (enExample)
WO (1) WO2015192093A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL296875A (en) 2014-12-31 2022-12-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
IL260206B2 (en) * 2015-12-21 2023-04-01 Nuvox Pharma Llc Preparations containing a nanoemulsion of fluorocarbons and methods for their preparation
US20190117800A1 (en) * 2016-04-19 2019-04-25 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
CN109641068B (zh) 2016-05-04 2022-09-30 蓝瑟斯医学影像公司 用于制备超声波造影剂的方法及装置
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3530266A1 (en) * 2018-02-27 2019-08-28 LipoCoat B.V. A lipid-based coating composition, and an object having a lipid-based coating
WO2019191557A1 (en) * 2018-03-29 2019-10-03 Case Wester Reserve University Stabilized nanobubbles and microbubbles for diagnostic and therapeutic applications
CN116173238A (zh) * 2018-03-29 2023-05-30 微脉管治疗有限公司 用于检测和治疗阿尔茨海默病的组合物及方法
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US20220387460A1 (en) * 2019-11-11 2022-12-08 Washington University Liposome compositions and methods of treatment targeted to tumor endothelium
CN111729094B (zh) * 2020-07-23 2021-07-02 四川大学华西医院 类磷脂两亲性嵌段共聚物基超声造影剂及其制备方法
NL2027237B1 (en) * 2020-12-27 2022-07-21 Solstice Pharmaceuticals B V Process for controlled manufacturing of mono-disperse microbubbles
CN116897055A (zh) * 2020-12-27 2023-10-17 索尔斯蒂斯制药有限公司 用于混合旨在用于体内使用的磷脂组合物的筒
US20240299653A1 (en) * 2020-12-27 2024-09-12 Solstice Pharmaceuticals B.V. A Cartridge for Mixing a Liquid Intended for Intracorporeal Use
JP2025506154A (ja) * 2022-02-09 2025-03-07 ランセウス メディカル イメージング， インコーポレイテッド ガスナノ／マイクロバブル組成物およびその使用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
IL122249A0 (en) * 1995-06-07 1998-04-05 Alliance Pharmceutical Corp Fluorocarbon pharmaceutical formulations and their preparation
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE69737915T2 (de) * 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
US6572840B1 (en) * 1999-07-28 2003-06-03 Bristol-Myers Squibb Pharma Company Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent
US7357937B2 (en) * 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
US20050025710A1 (en) * 2003-07-29 2005-02-03 Michel Schneider Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
CN101389273B (zh) * 2004-08-05 2012-09-05 贝勒研究院 基因或药物递送系统
EP2253308A1 (en) * 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US10279053B2 (en) * 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same

Also Published As

Publication number Publication date
CN107106692B (zh) 2021-01-05
EP3154591B1 (en) 2023-10-11
JP2017517533A (ja) 2017-06-29
US20160000943A1 (en) 2016-01-07
US9801959B2 (en) 2017-10-31
KR102379534B1 (ko) 2022-03-25
KR20170016462A (ko) 2017-02-13
WO2015192093A1 (en) 2015-12-17
US20190184038A1 (en) 2019-06-20
EP3154591C0 (en) 2023-10-11
EP3154591A1 (en) 2017-04-19
US11160885B2 (en) 2021-11-02
US10493173B2 (en) 2019-12-03
AU2015274259B2 (en) 2019-04-18
AU2015274259A1 (en) 2017-01-05
JP6594909B2 (ja) 2019-10-23
CN107106692A (zh) 2017-08-29
US20180092995A1 (en) 2018-04-05
EP3154591A4 (en) 2018-02-14
CA2951922A1 (en) 2015-12-17

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