KR102379534B1 - 인지질 조성 및 미세기포와 이를 이용하여 형성된 유탁액 - Google Patents

인지질 조성 및 미세기포와 이를 이용하여 형성된 유탁액 Download PDF

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KR102379534B1
KR102379534B1 KR1020177000514A KR20177000514A KR102379534B1 KR 102379534 B1 KR102379534 B1 KR 102379534B1 KR 1020177000514 A KR1020177000514 A KR 1020177000514A KR 20177000514 A KR20177000514 A KR 20177000514A KR 102379534 B1 KR102379534 B1 KR 102379534B1
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dppe
composition
lipid
peg
dppc
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KR20170016462A (ko
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에반 씨. 웅거
다니엘 씨. 에반스
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에반 씨. 웅거
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
KR1020177000514A 2014-06-12 2015-06-12 인지질 조성 및 미세기포와 이를 이용하여 형성된 유탁액 Active KR102379534B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462011469P 2014-06-12 2014-06-12
US62/011,469 2014-06-12
PCT/US2015/035681 WO2015192093A1 (en) 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same

Publications (2)

Publication Number Publication Date
KR20170016462A KR20170016462A (ko) 2017-02-13
KR102379534B1 true KR102379534B1 (ko) 2022-03-25

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KR1020177000514A Active KR102379534B1 (ko) 2014-06-12 2015-06-12 인지질 조성 및 미세기포와 이를 이용하여 형성된 유탁액

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US (3) US9801959B2 (enExample)
EP (1) EP3154591B1 (enExample)
JP (1) JP6594909B2 (enExample)
KR (1) KR102379534B1 (enExample)
CN (1) CN107106692B (enExample)
AU (1) AU2015274259B2 (enExample)
CA (1) CA2951922C (enExample)
WO (1) WO2015192093A1 (enExample)

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IL296875A (en) 2014-12-31 2022-12-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
IL260206B2 (en) * 2015-12-21 2023-04-01 Nuvox Pharma Llc Preparations containing a nanoemulsion of fluorocarbons and methods for their preparation
US20190117800A1 (en) * 2016-04-19 2019-04-25 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
CN109641068B (zh) 2016-05-04 2022-09-30 蓝瑟斯医学影像公司 用于制备超声波造影剂的方法及装置
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3530266A1 (en) * 2018-02-27 2019-08-28 LipoCoat B.V. A lipid-based coating composition, and an object having a lipid-based coating
WO2019191557A1 (en) * 2018-03-29 2019-10-03 Case Wester Reserve University Stabilized nanobubbles and microbubbles for diagnostic and therapeutic applications
CN116173238A (zh) * 2018-03-29 2023-05-30 微脉管治疗有限公司 用于检测和治疗阿尔茨海默病的组合物及方法
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US20220387460A1 (en) * 2019-11-11 2022-12-08 Washington University Liposome compositions and methods of treatment targeted to tumor endothelium
CN111729094B (zh) * 2020-07-23 2021-07-02 四川大学华西医院 类磷脂两亲性嵌段共聚物基超声造影剂及其制备方法
NL2027237B1 (en) * 2020-12-27 2022-07-21 Solstice Pharmaceuticals B V Process for controlled manufacturing of mono-disperse microbubbles
CN116897055A (zh) * 2020-12-27 2023-10-17 索尔斯蒂斯制药有限公司 用于混合旨在用于体内使用的磷脂组合物的筒
US20240299653A1 (en) * 2020-12-27 2024-09-12 Solstice Pharmaceuticals B.V. A Cartridge for Mixing a Liquid Intended for Intracorporeal Use
JP2025506154A (ja) * 2022-02-09 2025-03-07 ランセウス メディカル イメージング， インコーポレイテッド ガスナノ／マイクロバブル組成物およびその使用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010133700A1 (en) 2009-05-22 2010-11-25 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US20130022550A1 (en) 2011-07-19 2013-01-24 Unger Evan C Microbubble Compositions, Method of Making Same, and Method Using Same

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Publication number Priority date Publication date Assignee Title
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
IL122249A0 (en) * 1995-06-07 1998-04-05 Alliance Pharmceutical Corp Fluorocarbon pharmaceutical formulations and their preparation
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE69737915T2 (de) * 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
US6572840B1 (en) * 1999-07-28 2003-06-03 Bristol-Myers Squibb Pharma Company Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent
US7357937B2 (en) * 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
US20050025710A1 (en) * 2003-07-29 2005-02-03 Michel Schneider Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
CN101389273B (zh) * 2004-08-05 2012-09-05 贝勒研究院 基因或药物递送系统

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010133700A1 (en) 2009-05-22 2010-11-25 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US20130022550A1 (en) 2011-07-19 2013-01-24 Unger Evan C Microbubble Compositions, Method of Making Same, and Method Using Same

Also Published As

Publication number Publication date
CN107106692B (zh) 2021-01-05
EP3154591B1 (en) 2023-10-11
JP2017517533A (ja) 2017-06-29
US20160000943A1 (en) 2016-01-07
US9801959B2 (en) 2017-10-31
KR20170016462A (ko) 2017-02-13
WO2015192093A1 (en) 2015-12-17
US20190184038A1 (en) 2019-06-20
EP3154591C0 (en) 2023-10-11
EP3154591A1 (en) 2017-04-19
US11160885B2 (en) 2021-11-02
US10493173B2 (en) 2019-12-03
AU2015274259B2 (en) 2019-04-18
AU2015274259A1 (en) 2017-01-05
JP6594909B2 (ja) 2019-10-23
CN107106692A (zh) 2017-08-29
US20180092995A1 (en) 2018-04-05
EP3154591A4 (en) 2018-02-14
CA2951922A1 (en) 2015-12-17
CA2951922C (en) 2023-02-28

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