JP6594902B2 - ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物及びその使用方法 - Google Patents

ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物及びその使用方法 Download PDF

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JP6594902B2
JP6594902B2 JP2016568484A JP2016568484A JP6594902B2 JP 6594902 B2 JP6594902 B2 JP 6594902B2 JP 2016568484 A JP2016568484 A JP 2016568484A JP 2016568484 A JP2016568484 A JP 2016568484A JP 6594902 B2 JP6594902 B2 JP 6594902B2
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nucleotide
nucleotides
double
rnai agent
irna
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JP2017509354A5 (enExample
JP2017509354A (ja
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ケビン・フィッツジェラルド
ブライアン・ベッテンコート
グレゴリー・ヒンクル
ジェニファー・ウィロビー
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Alnylam Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01003—Ketohexokinase (2.7.1.3)

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JP2016568484A 2014-02-11 2015-02-11 ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物及びその使用方法 Active JP6594902B2 (ja)

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Application Number Priority Date Filing Date Title
US201461938567P 2014-02-11 2014-02-11
US61/938,567 2014-02-11
PCT/US2015/015367 WO2015123264A1 (en) 2014-02-11 2015-02-11 Ketohexokinase (khk) irna compositions and methods of use thereof

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JP2019173883A Division JP7062623B2 (ja) 2014-02-11 2019-09-25 ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物及びその使用方法

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JP2017509354A JP2017509354A (ja) 2017-04-06
JP2017509354A5 JP2017509354A5 (enExample) 2018-03-22
JP6594902B2 true JP6594902B2 (ja) 2019-10-23

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JP2019173883A Active JP7062623B2 (ja) 2014-02-11 2019-09-25 ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物及びその使用方法
JP2022069642A Active JP7559001B2 (ja) 2014-02-11 2022-04-20 ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物及びその使用方法
JP2024161345A Pending JP2024178284A (ja) 2014-02-11 2024-09-18 ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物及びその使用方法

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JP2022069642A Active JP7559001B2 (ja) 2014-02-11 2022-04-20 ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物及びその使用方法
JP2024161345A Pending JP2024178284A (ja) 2014-02-11 2024-09-18 ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物及びその使用方法

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US (5) US10370666B2 (enExample)
EP (2) EP3960860A3 (enExample)
JP (4) JP6594902B2 (enExample)
KR (3) KR20230152154A (enExample)
CN (3) CN118845818A (enExample)
AU (3) AU2015217301A1 (enExample)
CA (1) CA2938857A1 (enExample)
EA (1) EA201691587A1 (enExample)
WO (1) WO2015123264A1 (enExample)

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TWI851574B (zh) * 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
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KR20220084399A (ko) * 2019-10-22 2022-06-21 알닐람 파마슈티칼스 인코포레이티드 보체 성분 C3 iRNA 조성물 및 이의 사용 방법
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