JP6588004B2 - Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法 - Google Patents

Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法 Download PDF

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JP6588004B2
JP6588004B2 JP2016502984A JP2016502984A JP6588004B2 JP 6588004 B2 JP6588004 B2 JP 6588004B2 JP 2016502984 A JP2016502984 A JP 2016502984A JP 2016502984 A JP2016502984 A JP 2016502984A JP 6588004 B2 JP6588004 B2 JP 6588004B2
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cells
seq
cd123car
nucleic acid
cell
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JP2016514457A5 (enExample
JP2016514457A (ja
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フォーマン，スティーヴン・ジェイ
マルディロス，アーメン
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City of Hope
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
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    • A61K40/4214—Receptors for cytokines
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2016502984A 2013-03-15 2014-03-14 Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法 Expired - Fee Related JP6588004B2 (ja)

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Application Number Priority Date Filing Date Title
US13/844,048 2013-03-15
US13/844,048 US9657105B2 (en) 2013-03-15 2013-03-15 CD123-specific chimeric antigen receptor redirected T cells and methods of their use
PCT/US2014/029109 WO2014144622A2 (en) 2013-03-15 2014-03-14 Cd123-specific chimeric antigen receptor redirected t cells and methods of their use

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JP2019166068A Division JP6793800B2 (ja) 2013-03-15 2019-09-12 Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法

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JP2016514457A JP2016514457A (ja) 2016-05-23
JP2016514457A5 JP2016514457A5 (enExample) 2016-06-30
JP6588004B2 true JP6588004B2 (ja) 2019-10-09

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JP2016502984A Expired - Fee Related JP6588004B2 (ja) 2013-03-15 2014-03-14 Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法
JP2019166068A Expired - Fee Related JP6793800B2 (ja) 2013-03-15 2019-09-12 Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法
JP2020187011A Active JP7160882B2 (ja) 2013-03-15 2020-11-10 Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法
JP2022164487A Pending JP2022191388A (ja) 2013-03-15 2022-10-13 Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法

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JP2020187011A Active JP7160882B2 (ja) 2013-03-15 2020-11-10 Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法
JP2022164487A Pending JP2022191388A (ja) 2013-03-15 2022-10-13 Ｃｄ１２３特異的キメラ抗原受容体でリダイレクトしたｔ細胞およびそれらの使用方法

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US (3) US9657105B2 (enExample)
EP (2) EP3626247B1 (enExample)
JP (4) JP6588004B2 (enExample)
KR (4) KR102297918B1 (enExample)
CN (2) CN105392887B (enExample)
AU (3) AU2014228911A1 (enExample)
BR (1) BR112015023701B1 (enExample)
CA (1) CA2907216C (enExample)
DK (1) DK2968415T3 (enExample)
ES (1) ES2747099T3 (enExample)
IL (4) IL289883B2 (enExample)
MX (2) MX2015013195A (enExample)
RU (1) RU2711114C2 (enExample)
WO (1) WO2014144622A2 (enExample)

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