JP6576828B2 - ニューロテンシン受容体リガンド - Google Patents

ニューロテンシン受容体リガンド Download PDF

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Publication number
JP6576828B2
JP6576828B2 JP2015545697A JP2015545697A JP6576828B2 JP 6576828 B2 JP6576828 B2 JP 6576828B2 JP 2015545697 A JP2015545697 A JP 2015545697A JP 2015545697 A JP2015545697 A JP 2015545697A JP 6576828 B2 JP6576828 B2 JP 6576828B2
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compound
formula
group
acceptor
radionuclide
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Japanese (ja)
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JP2016501238A (ja
Inventor
オスターカンプ，フランク
スメルリング，クリスティアーネ
ライネッケ，ウルリヒ
ハーゼ，クリスティアン
ウンゲヴィス，ヤン
Original Assignee
スリービー・ファーマシューティカルズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2015545697A 2012-12-07 2013-12-06 ニューロテンシン受容体リガンド Active JP6576828B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12008208.6A EP2740726A1 (en) 2012-12-07 2012-12-07 Neurotensin receptor ligands
EP12008208.6 2012-12-07
PCT/EP2013/003700 WO2014086499A1 (en) 2012-12-07 2013-12-06 Neurotensin receptor ligands

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019150947A Division JP7042776B2 (ja) 2012-12-07 2019-08-21 ニューロテンシン受容体リガンド

Publications (2)

Publication Number Publication Date
JP2016501238A JP2016501238A (ja) 2016-01-18
JP6576828B2 true JP6576828B2 (ja) 2019-09-18

Family

ID=47355771

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015545697A Active JP6576828B2 (ja) 2012-12-07 2013-12-06 ニューロテンシン受容体リガンド
JP2019150947A Active JP7042776B2 (ja) 2012-12-07 2019-08-21 ニューロテンシン受容体リガンド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019150947A Active JP7042776B2 (ja) 2012-12-07 2019-08-21 ニューロテンシン受容体リガンド

Country Status (20)

Country Link
US (2) US10961199B2 (OSRAM)
EP (3) EP2740726A1 (OSRAM)
JP (2) JP6576828B2 (OSRAM)
KR (1) KR102290803B1 (OSRAM)
CN (2) CN109320502B (OSRAM)
AU (1) AU2013354422B2 (OSRAM)
BR (1) BR112015012530B1 (OSRAM)
CA (1) CA2893605C (OSRAM)
DK (2) DK2928870T3 (OSRAM)
ES (2) ES2941629T3 (OSRAM)
FI (1) FI3712131T3 (OSRAM)
HU (2) HUE061839T2 (OSRAM)
IL (1) IL239080B (OSRAM)
MX (1) MX370354B (OSRAM)
PL (2) PL3712131T3 (OSRAM)
PT (2) PT2928870T (OSRAM)
RU (1) RU2671970C2 (OSRAM)
SG (2) SG10201704564QA (OSRAM)
WO (1) WO2014086499A1 (OSRAM)
ZA (1) ZA201503446B (OSRAM)

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EP2954933A1 (en) * 2014-06-10 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand
EP2954934A1 (en) * 2014-06-11 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand and use thereof
AU2015273934B2 (en) * 2014-06-10 2020-08-20 3B Pharmaceuticals Gmbh Conjugate comprising a neurotensin receptor ligand and use thereof
ES2882634T3 (es) 2015-11-24 2021-12-02 Transfert Plus Sec Compuestos peptídicos y conjugados con péptidos para el tratamiento del cáncer mediante quimioterapia mediada por receptores
EP3279197A1 (en) 2016-08-03 2018-02-07 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis, treatment and prevention of neurotensin receptor-related conditions
MA46952A (fr) 2016-12-01 2019-10-09 Regeneron Pharma Anticorps anti-pd-l1 radiomarqués pour imagerie immuno-pet
MY200034A (en) 2017-02-10 2023-12-05 Regeneron Pharma Radiolabeled anti-lag3 antibodies for immuno-pet imaging
BR112020001360A2 (pt) 2017-07-24 2020-08-11 Regeneron Pharmaceuticals, Inc. anticorpo monoclonal isolado ou fragmento de ligação a antígeno deste que se liga a cd8, composição farmacêutica, molécula de ácido nucleico, vetor de expressão, célula hospedeira, conjugado de anticorpo, métodos para gerar imagens de um tecido que expressa cd8, para tratar um sujeito tendo um tumor sólido, para prever uma resposta positiva a uma terapia antitumoral, para monitorar uma resposta de um tumor em um sujeito a uma terapia antitumoral, para prever ou monitorar a eficácia da terapia antitumoral e para monitorar a presença de células t em um tumor ao longo do tempo, e, composto.
JP7608425B2 (ja) 2019-07-08 2025-01-06 ３ベー ファーマシューティカルズ ゲーエムベーハー 線維芽細胞活性化タンパク質リガンドを含む化合物およびその使用
CN111875667B (zh) * 2020-07-16 2021-12-21 南方科技大学 有机金属螯合物及其制备方法与应用、探针
AU2021364978A1 (en) * 2020-10-22 2023-06-15 Nihon Medi-Physics Co., Ltd. Method for producing radioactive zirconium complex
CA3217024A1 (en) * 2021-04-23 2022-10-27 Fusion Pharmaceuticals Inc. Methods for treatment of cancers
EP4352044A4 (en) * 2021-05-13 2025-10-22 Massachusetts Gen Hospital MOLECULAR PROBES FOR IN VIVO DETECTION OF ALDEHYDES
WO2022261771A1 (en) * 2021-06-16 2022-12-22 Fusion Pharmaceuticals Inc. Combination comprising a neurotensin receptor binding compound, gemcitabine and nab-paclitaxel
WO2022261770A1 (en) * 2021-06-16 2022-12-22 Fusion Pharmaceuticals Inc. Combination comprising a neurotensin receptor binding compound and folfirinox
WO2022266357A1 (en) * 2021-06-16 2022-12-22 Fusion Pharmaceuticals Inc. Combination comprising a neurotensin receptor binding compound and napox
WO2023141722A1 (en) * 2022-01-28 2023-08-03 Fusion Pharmaceuticals Inc. Ntsr1-targeted radiopharmaceuticals and checkpoint inhibitor combination therapy
JP2025506705A (ja) 2022-02-18 2025-03-13 フル－ライフ・テクノロジーズ・ホンコン・リミテッド ニューロテンシン受容体を標的とする化合物および放射性リガンドおよびその使用
KR20250004887A (ko) * 2022-05-03 2025-01-08 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 영상화 및 요법 적용을 위한 ntsr 표적화 제제의 개발
US12091454B2 (en) 2022-12-28 2024-09-17 Development Center For Biotechnology Humanized anti-human neurotensin receptor 1 antibodies and their uses
WO2025144920A1 (en) * 2023-12-28 2025-07-03 Radionetics Oncology, Inc. Neuropeptide y1 receptor (npy1r) targeted therapeutics and uses thereof
WO2025146126A1 (en) * 2024-01-04 2025-07-10 Full-Life Technologies Hk Limited Preparation method of compounds targeting neurotensin receptor

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Also Published As

Publication number Publication date
CN109320502B (zh) 2022-06-07
PL2928870T3 (pl) 2020-09-21
EP3712131A1 (en) 2020-09-23
FI3712131T3 (fi) 2023-03-28
DK3712131T3 (da) 2023-03-20
MX370354B (es) 2019-12-10
WO2014086499A1 (en) 2014-06-12
CN109320502A (zh) 2019-02-12
BR112015012530B1 (pt) 2022-07-19
SG11201503880YA (en) 2015-06-29
KR102290803B1 (ko) 2021-08-18
CN104837819A (zh) 2015-08-12
EP2740726A1 (en) 2014-06-11
EP3712131B1 (en) 2023-02-01
AU2013354422B2 (en) 2018-03-15
MX2015007193A (es) 2016-03-17
JP2019218375A (ja) 2019-12-26
US20210087149A1 (en) 2021-03-25
EP2928870A1 (en) 2015-10-14
HUE061839T2 (hu) 2023-08-28
ES2795923T3 (es) 2020-11-25
BR112015012530A2 (pt) 2017-09-12
RU2015127086A (ru) 2017-01-11
PT3712131T (pt) 2023-04-04
IL239080A0 (en) 2015-07-30
CA2893605A1 (en) 2014-06-12
DK2928870T3 (da) 2020-07-13
ES2941629T3 (es) 2023-05-24
JP7042776B2 (ja) 2022-03-28
IL239080B (en) 2019-06-30
WO2014086499A8 (en) 2014-12-31
US20150299133A1 (en) 2015-10-22
CN104837819B (zh) 2018-12-07
US10961199B2 (en) 2021-03-30
RU2671970C2 (ru) 2018-11-08
KR20150092300A (ko) 2015-08-12
SG10201704564QA (en) 2017-07-28
HK1210148A1 (en) 2016-04-15
EP2928870B1 (en) 2020-04-08
HUE050388T2 (hu) 2020-11-30
CN104837819B9 (zh) 2019-07-09
JP2016501238A (ja) 2016-01-18
CA2893605C (en) 2021-08-10
AU2013354422A1 (en) 2015-05-28
ZA201503446B (en) 2016-01-27
PT2928870T (pt) 2020-05-29
PL3712131T3 (pl) 2023-05-02

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