JP6574848B2 - Ｃｄ１９結合ドメインを含むキメラ抗原レセプター（ｃａｒ） - Google Patents

Ｃｄ１９結合ドメインを含むキメラ抗原レセプター（ｃａｒ） Download PDF

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JP6574848B2
JP6574848B2 JP2017546104A JP2017546104A JP6574848B2 JP 6574848 B2 JP6574848 B2 JP 6574848B2 JP 2017546104 A JP2017546104 A JP 2017546104A JP 2017546104 A JP2017546104 A JP 2017546104A JP 6574848 B2 JP6574848 B2 JP 6574848B2
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car
cell
cells
endodomain
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JP2018508215A (ja
JP2018508215A5 (enExample
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マーティン プーレ，
マーティン プーレ，
レイラ メッカオウイ，
レイラ メッカオウイ，
パーシス アムロリア，
パーシス アムロリア，
サラ ゴラシアン，
サラ ゴラシアン，
アン クレイマー，
アン クレイマー，
ゴードン チェン，
ゴードン チェン，
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ユーシーエル ビジネス ピーエルシー
ユーシーエル ビジネス ピーエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2017546104A 2015-03-05 2016-03-04 Ｃｄ１９結合ドメインを含むキメラ抗原レセプター（ｃａｒ） Active JP6574848B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201503742A GB201503742D0 (en) 2015-03-05 2015-03-05 Chimeric antigen receptor
GB1503742.7 2015-03-05
PCT/GB2016/050574 WO2016139487A1 (en) 2015-03-05 2016-03-04 Chimeric antigen receptor (car) comprising a cd19-binding domain

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JP2018508215A JP2018508215A (ja) 2018-03-29
JP2018508215A5 JP2018508215A5 (enExample) 2019-03-07
JP6574848B2 true JP6574848B2 (ja) 2019-09-11

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US (3) US10457730B2 (enExample)
EP (1) EP3265490B1 (enExample)
JP (1) JP6574848B2 (enExample)
CN (1) CN107406517B (enExample)
AU (1) AU2016227498B2 (enExample)
CA (1) CA2978381C (enExample)
DK (1) DK3265490T3 (enExample)
ES (1) ES2732067T3 (enExample)
FR (1) FR25C1040I1 (enExample)
GB (1) GB201503742D0 (enExample)
HU (2) HUE044298T2 (enExample)
NL (1) NL301348I2 (enExample)
PL (1) PL3265490T3 (enExample)
PT (1) PT3265490T (enExample)
TR (1) TR201909647T4 (enExample)
WO (1) WO2016139487A1 (enExample)

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