JP6546206B2 - 精神能力を向上させるためのイソマルツロースの使用 - Google Patents
精神能力を向上させるためのイソマルツロースの使用 Download PDFInfo
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- JP6546206B2 JP6546206B2 JP2017007135A JP2017007135A JP6546206B2 JP 6546206 B2 JP6546206 B2 JP 6546206B2 JP 2017007135 A JP2017007135 A JP 2017007135A JP 2017007135 A JP2017007135 A JP 2017007135A JP 6546206 B2 JP6546206 B2 JP 6546206B2
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Description
方法
75人の健康な学童が、多量栄養素含有量が同じであるが、その血糖負荷(GL;炭水化物の量×食品の血糖指数GI;イソマルツロースのGI = 32、グルコースのGI = 100)が異なるように設計された2種の食事をクロスオーバー法で摂取した。認識試験ブロックは45分間かかり、食事の摂取後、初期食後相において1回、後期食後相(>150分)において1回評価した。すべての子供は4ブロックの試験に参加した(図2)。
・食事Aの後の初期試験ブロック
・食事Aの後の後期試験ブロック
・食事Bの後の初期試験ブロック
・食事Bの後の後期試験ブロック
それぞれの認識試験ブロックにおいて、相等しいバージョンの認識試験をおこなった。
両方の食事は同じエネルギー(1385 KJ)および多量栄養素(84.4 %炭水化物、10.6 %タンパク質および5.0 %脂肪)の取り込みを提供したが、血糖負荷(GL:炭水化物の量×食品の血糖指数)、すなわち、グルコースが血流中にゆっくりと放出されるか、急速に放出されるかが異なっていた。食事は以下の通りに構成された(総エネルギーに対する%):
・高GL食:コーンフレーク+牛乳(35.3 %)、ヨーグルト+果実調製品(14.2 %)、グルコース(50.5 %)。
・低GL食:コーンフレーク+牛乳(35.3 %)、ヨーグルト+果実調製品(14.2 %)、イソマルツロース(50.5 %)。
方法は、英国能力尺度の物体の記憶試験(Recall of Objects test of the British Ability Scales)(Elliott, British Ability Scales, 1996, National foundation of Educational Research)に基づき、子供は60までの物体を思い出すことを求められた。
結果を図3に示す。食事の摂取の後、初期食後相においてエピソード記憶を評価した場合には、2つの群において結果は同様であった。しかしながら、後期食後相(食事の摂取の後 > 150分)において、イソマルツロースを摂取した者は、より高いGLを有するグルコース食を摂取した子供と比較して優れたエピソード記憶を有した。
結果をエラー率で表して注意力を評価するためにShakowのパラダイムを用いた(Shakow, Arch general Psychiat, 1962, 6, 1-17)。この信号検出試験において、子供は遅らせた光刺激に対してできる限り速く応答することを求められた。
結果を図4に示す。初期食後相において、両方の食事はほぼ同じエラー率を引き起こした。後期食後相(食事の摂取の後 > 150分)において、イソマルツロース食により、グルコース食と比較して注意能力が良くなる傾向(すなわち、より低いエラー率)があった。エラー率における絶対的なパーセンテージの増加はイソマルツロース群よりもグルコース群において高く、イソマルツロースにより、後期食後相においてグルコースを含有する高GL食よりも優れた注意能力が得られることが示された。
本発明の実施形態として例えば以下を挙げることができる。
[実施形態1]
それを必要とする被験体の血糖応答後の相における精神能力を向上させるためのイソマルツロースの使用。
[実施形態2]
向上が、高血糖指数食品の摂取の後の血糖応答後の相における精神能力のレベルと比較した精神能力の向上である、実施形態1に記載の使用。
[実施形態3]
精神能力が、集中力、注意力、記憶、応答時間および情報処理の速度からなる群より選択される、実施形態1に記載の使用。
[実施形態4]
記憶が、エピソード記憶および空間記憶からなる群より選択される、実施形態1〜3のいずれかに記載の使用。
[実施形態5]
血糖応答後の相が超後期相である、実施形態1〜4のいずれかに記載の使用。
[実施形態6]
血糖応答後の相が、それを必要とする被験体がイソマルツロースを摂取した後、150分超〜6時間である、実施形態1〜5のいずれかに記載の使用。
[実施形態7]
子供、青年および成人の精神能力が向上する、実施形態1〜6のいずれかに記載の使用。
[実施形態8]
それを必要とする被験体により摂取されるイソマルツロースの用量が0.1 g/kg〜1.7 g/kg体重である、実施形態1〜7のいずれかに記載の使用。
[実施形態9]
それを必要とする被験体の血糖応答後の相における血中グルコース値が、血糖応答前の相における血中グルコースの初期値の+/- 15 %、より好ましくは+/- 10 %に近い値を有する、実施形態1〜8のいずれかに記載の使用。
[実施形態10]
糖、糖アルコールおよび高強度甘味料の群より選択される別の甘味剤と共に使用される、実施形態1〜9のいずれかに記載の使用。
[実施形態11]
食品、飲料または医薬品中で使用される、実施形態1〜10のいずれかに記載の使用。
[実施形態12]
それを必要とする被験体の血糖応答後の相における精神能力を向上させるための、イソマルツロースを含む食品、飲料または医薬品の使用。
[実施形態13]
飲料が、ソフトドリンク、水をベースとする飲料、スポーツ飲料、ゼリー飲料、茶飲料、ココア飲料、コーヒー飲料、アルコール飲料、エネルギー飲料、果汁飲料またはファンドリンクからなる群より選択される、実施形態12に記載の使用。
[実施形態14]
食品が、シリアル、乳製品、菓子類、チューインガム、ベーカリー製品およびゼリーからなる群より選択される、実施形態12または13に記載の使用。
Claims (9)
- 被験体に0.1 g/kg〜1.7 g/kg体重の用量でイソマルツロースを投与するための、かつ被験体の精神能力を向上させるためのイソマルツロースを含む組成物であって、該組成物を摂取した被験体における精神能力が、炭水化物を含む食事により引き起こされ、炭水化物を含む食事の後に生じる該被験体の上昇した血中グルコース値が摂取前の初期値の+/- 15%に戻った血糖応答後の相の後期食後応答相において向上しており、かつ前記後期食後応答相が、被験体によるイソマルツロースの摂取から180分後であり、その間、血糖応答後の相を特徴付ける被験体の前記血中グルコース値が維持され、精神能力がエピソード記憶である、前記組成物。
- 精神能力の向上が、高血糖指数食品の摂取の後の血糖応答後の相における精神能力のレベルと比較した向上である、請求項1に記載の組成物。
- 被験体が、子供、青年または成人である、請求項1または2に記載の組成物。
- 血糖応答後の相において、被験体の血中グルコース値が摂取前の初期値の+/- 10%に戻っている、請求項1〜3のいずれか1項に記載の組成物。
- 糖、糖アルコールおよび高強度甘味料の群より選択される別の甘味剤と共に使用される、請求項1〜4のいずれか1項に記載の組成物。
- 食品または飲料の形態である、請求項1〜5のいずれか1項に記載の組成物。
- シリアル、乳製品、菓子類、チューインガム、ベーカリー製品またはゼリーの形態である、請求項6に記載の組成物。
- ソフトドリンク、水をベースとする飲料、スポーツ飲料、ゼリー飲料、茶飲料、ココア飲料、コーヒー飲料、アルコール飲料、エネルギー飲料、果汁飲料またはファンドリンクの形態である、請求項6に記載の組成物。
- 医薬組成物である、請求項1〜5のいずれか1項に記載の組成物。
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JP2015093749A Pending JP2015165808A (ja) | 2010-07-14 | 2015-05-01 | 精神能力を向上させるためのイソマルツロースの使用 |
JP2017007135A Active JP6546206B2 (ja) | 2010-07-14 | 2017-01-19 | 精神能力を向上させるためのイソマルツロースの使用 |
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CN104055189A (zh) * | 2014-03-14 | 2014-09-24 | 上海键源碳水化合物有限公司 | 蔗糖转化糖在功能性饮料中的应用 |
CN106036678A (zh) * | 2016-05-31 | 2016-10-26 | 山东福田药业有限公司 | 缓慢释放能量的果冻及其制备方法 |
CN108577865B (zh) * | 2018-03-14 | 2022-02-22 | 天使智心(北京)科技有限公司 | 一种心理状态确定方法及装置 |
JP7316035B2 (ja) * | 2018-11-15 | 2023-07-27 | Dm三井製糖株式会社 | 眠気抑制剤及び眠気抑制用飲食品 |
CN110771683B (zh) * | 2019-12-03 | 2022-11-18 | 河南花花牛乳业集团股份有限公司 | 一种风味发酵乳及其制备方法 |
JP2024021800A (ja) * | 2022-08-04 | 2024-02-16 | Dm三井製糖株式会社 | 脳血流量増加剤、脳活動促進剤及び覚醒度向上剤 |
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JP2000245390A (ja) * | 1999-02-25 | 2000-09-12 | Ezaki Glico Co Ltd | 精神的な高揚感が持続する、腹持ちが良く嗜好性の高い食品ならびに飲料 |
JP4860840B2 (ja) * | 2001-05-14 | 2012-01-25 | 三井製糖株式会社 | 集中力及び注意力を持続させる剤及び該剤を含む飲食物 |
JP2003155240A (ja) * | 2001-11-16 | 2003-05-27 | Shin Mitsui Sugar Co Ltd | 集中力及び注意力を持続させる剤及び該剤を含む飲食物 |
JP4048166B2 (ja) * | 2002-11-18 | 2008-02-13 | 三井製糖株式会社 | 血糖値上昇抑制剤及び体脂肪蓄積抑制剤並びに食用材料 |
CN100448374C (zh) * | 2002-11-18 | 2009-01-07 | 三井制糖株式会社 | 血糖值上升抑制剂、体脂肪蓄积抑制剂以及食用材料 |
KR101043212B1 (ko) * | 2004-11-03 | 2011-06-21 | 주식회사 한국인삼공사 | 뇌 기능 개선용 건강기능식품 |
ES2419205T3 (es) * | 2005-04-06 | 2013-08-19 | Nestec S.A. | Composición para mejorar la regulación de la glicemia y la acción de la insulina, por vía nutritiva |
DE102007026975A1 (de) * | 2007-06-01 | 2008-12-04 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Antioxidationsmittel für Lebensmittel |
JP5420223B2 (ja) * | 2008-10-16 | 2014-02-19 | 三井製糖株式会社 | 筋肉量低下抑制剤 |
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EP2592950A1 (en) | 2013-05-22 |
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BR112012033739A8 (pt) | 2018-08-14 |
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JP2015165808A (ja) | 2015-09-24 |
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