JP6538153B2 - Ｒｅａｒｒａｎｇｅｄ ｄｕｒｉｎｇ ｔｒａｎｓｆｅｃｔｉｏｎ（ｒｅｔ）阻害剤としての新規な化合物 - Google Patents

Ｒｅａｒｒａｎｇｅｄ ｄｕｒｉｎｇ ｔｒａｎｓｆｅｃｔｉｏｎ（ｒｅｔ）阻害剤としての新規な化合物 Download PDF

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JP6538153B2
JP6538153B2 JP2017513448A JP2017513448A JP6538153B2 JP 6538153 B2 JP6538153 B2 JP 6538153B2 JP 2017513448 A JP2017513448 A JP 2017513448A JP 2017513448 A JP2017513448 A JP 2017513448A JP 6538153 B2 JP6538153 B2 JP 6538153B2
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alkyl
trifluoromethyl
phenyl
oxo
mmol
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JP2017526711A5 (OSRAM
JP2017526711A (ja
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ムイ、チュン
マイケル、ピー．デマーティノ
ヒラリー、シェンク、アイダム
グアン、ホイピン、エイミー
ドンホイ、チン
チェンデ、ウー
ゴン、ゼン
ヤン、ハイイン
ユ、ハイユ
チャン、ジリウ
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GlaxoSmithKline Intellectual Property Development Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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JP2017513448A 2014-09-10 2015-09-10 Ｒｅａｒｒａｎｇｅｄ ｄｕｒｉｎｇ ｔｒａｎｓｆｅｃｔｉｏｎ（ｒｅｔ）阻害剤としての新規な化合物 Expired - Fee Related JP6538153B2 (ja)

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CNPCT/CN2014/000834 2014-09-10
CN2014000834 2014-09-10
PCT/CN2015/089332 WO2016037578A1 (en) 2014-09-10 2015-09-10 Novel compounds as rearranged during transfection (ret) inhibitors

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JP2017526711A JP2017526711A (ja) 2017-09-14
JP2017526711A5 JP2017526711A5 (OSRAM) 2018-10-18
JP6538153B2 true JP6538153B2 (ja) 2019-07-03

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